Evaluation of Biocleanse Allografts For ACL Reconstruction

NCT ID: NCT00187876

Last Updated: 2014-03-04

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

67 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-02-29

Study Completion Date

2012-12-31

Brief Summary

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The purpose of this study is to determine the efficacy of patellar tendon allografts that have undergone the BioCleanse™ process.

Detailed Description

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The purpose of this study is to determine the efficacy of patellar tendon allografts that have undergone the BioCleanse™ process.

You are being asked to volunteer in a research study. The purpose of this study is to compare the different ways of cleaning allograft tendons used to replace the main ligament in the knee. The anterior cruciate ligament (ACL) is the main ligament in the knee that your doctor will replace in your surgery. The allograft tendons come from other people who have donated a tendon from the front of the knee after they died.

The three ways of cleaning the tendons that will be used in this study are BioCleanse, irradiation, and aseptic. Aseptic uses clean conditions when preparing the tissue for surgery, sometimes with a chemical bath. BioCleanse is a way of cleaning the tendon physically and chemically, while irradiation uses gamma rays. The goal is to clean the tendons to make them safer for the patients without weakening the tendon when put in the knee.

Conditions

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Anterior Cruciate Ligament Tear

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ACL reconstruction control

The intervention consists of the reconstruction of the ACL ligament using patellar tendon allografts.

Group Type ACTIVE_COMPARATOR

ACL reconstruction control

Intervention Type PROCEDURE

The intervention consists of the reconstruction of the ACL ligament using patellar tendon allografts that have undergone the BioCleanse™ process.

ACL Biocleanse, surgical

The intervention consists of the surgical reconstruction of the ACL ligament using patellar tendon allografts that have undergone the BioCleanse™ process.

Group Type EXPERIMENTAL

ACL Biocleanse, surgical

Intervention Type PROCEDURE

The intervention consists of the surgical reconstruction of the ACL ligament using patellar tendon allografts that have undergone the BioCleanse™ process.

Interventions

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ACL reconstruction control

The intervention consists of the reconstruction of the ACL ligament using patellar tendon allografts that have undergone the BioCleanse™ process.

Intervention Type PROCEDURE

ACL Biocleanse, surgical

The intervention consists of the surgical reconstruction of the ACL ligament using patellar tendon allografts that have undergone the BioCleanse™ process.

Intervention Type PROCEDURE

Other Intervention Names

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Standard ACL allograft BioCleanse™ process

Eligibility Criteria

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Inclusion Criteria

* ACL reconstruction

Exclusion Criteria

* none
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter A. Indelicato, M.D.

Role: PRINCIPAL_INVESTIGATOR

University of Florida

Locations

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UF Orthopedics and Sports Medicine Institute

Gainesville, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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566-2003

Identifier Type: -

Identifier Source: org_study_id

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