ACL Reconstruction With Simple and Double Bundle Technique Using Two Different Implants for Graft Fixation

NCT ID: NCT04550299

Last Updated: 2020-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

112 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-02-26

Study Completion Date

2023-12-01

Brief Summary

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In this study our objective is to compare two tibial ACL graft fixation systems in patients undergoing two different reconstructions technique (with simple and double bundle) in terms of tendon graft osteointegration, functionality and return to sports.

Detailed Description

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In this study our objective is to compare two tibial ACL graft fixation systems in patients undergoing two different reconstructions technique (with simple and double bundle) in terms of tendon graft osteointegration, functionality and return to sports.

This is a single-center prospective randomized clinical trial with 112 patients diagnosed with anterior cruciate ligament rupture randomly allocated in four groups: single bundle with autologous bioabsorbable implant; single bundle with intrafix implant; double bundle with autologous bioabsorbable implant; double bundle with intrafix implant.

Primary outcome is graft ligamentization assessed in MRI images at 4-6 months

Conditions

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Knee Injuries ACL Tear ACL Injury Sports Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group A

single bundle technique with the use of bioabsorbable implants

Group Type ACTIVE_COMPARATOR

Surgical technique combined with a specific choice of the material for the ligament reconstruction

Intervention Type OTHER

The surgical procedure is done as standard of care. The intervention is to randomize the participant into the study arms, which none of those has been proved yet to be a superior choice

Group B

single bundle technique with the use of Bio-Intrafix

Group Type ACTIVE_COMPARATOR

Surgical technique combined with a specific choice of the material for the ligament reconstruction

Intervention Type OTHER

The surgical procedure is done as standard of care. The intervention is to randomize the participant into the study arms, which none of those has been proved yet to be a superior choice

Group C

double bundle technique with the use of bioabsorbable implants

Group Type ACTIVE_COMPARATOR

Surgical technique combined with a specific choice of the material for the ligament reconstruction

Intervention Type OTHER

The surgical procedure is done as standard of care. The intervention is to randomize the participant into the study arms, which none of those has been proved yet to be a superior choice

Group D

double bundle technique with the use of Bio-Intrafix

Group Type ACTIVE_COMPARATOR

Surgical technique combined with a specific choice of the material for the ligament reconstruction

Intervention Type OTHER

The surgical procedure is done as standard of care. The intervention is to randomize the participant into the study arms, which none of those has been proved yet to be a superior choice

Interventions

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Surgical technique combined with a specific choice of the material for the ligament reconstruction

The surgical procedure is done as standard of care. The intervention is to randomize the participant into the study arms, which none of those has been proved yet to be a superior choice

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

isolated ACL injury for more than six weeks by physical examination and confirmed by magnetic resonance, adult non-elderly (18 to 60 years), nonobese (body mass index within the normal range)

Exclusion Criteria

intraoperative complications requiring change in technique of reconstruction and / or anesthesia during surgery, patients undergoing cartilage piercing procedures ( such as microfractures) and / or meniscus suture, those with allergies to medications administered during anesthesia, surgery and / or post-operative patients with tourniquet time of more than two hours and patients who did not sign the consent form
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Johnson & Johnson

INDUSTRY

Sponsor Role collaborator

Vita Care

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wagner Castropil

Role: PRINCIPAL_INVESTIGATOR

Instituto Vita

Locations

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Instituto Vita

São Paulo, São Paulo, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Instituto Vita

Role: CONTACT

Wagner Castropil

Role: CONTACT

Facility Contacts

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Wagner Castropil, PhD

Role: primary

Other Identifiers

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022

Identifier Type: -

Identifier Source: org_study_id

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