The Immune System and Psychiatric Disorders

NCT ID: NCT00184418

Last Updated: 2017-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-01-31

Study Completion Date

2008-01-31

Brief Summary

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The study is based on a hypothesis that there is interaction between the activity in the immune system and in the mind. To study this, the investigators register different measures for activity in the immune system on patients unselectedly admitted to an acute psychiatric ward. The psychiatric statuses and diagnoses of these patients are carefully defined as well.

Detailed Description

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Our hypotheses are first that activity in the immune system influences the psychiatric status in general, second that changes in activity in psychiatric status affect activity in the immune system and third that there are connections between certain psychiatric conditions/disorders and certain features of the immune system.

All patients admitted to a psychiatric acute ward covering an area with a population of 130.000 and with around 1000 admittances to an acute psychiatric ward a year (some readmittances) are asked to participate in the study. Patients fill in a question form regarding psychiatric as well as somatic health with emphasis on diseases involving immune activity. When possible also slight information on the family is registered. Both at the time of admittance and after recovery clinical laboratory tests on somatic status are registered. In addition the level of different cytokines is measured. The psychiatric state and precise diagnoses are registered during the stay. The data will be analysed to uncover connections between psychiatric stress in general as well as specific psychiatric diagnoses and activity in the immune system.

Conditions

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Stress Disorders, Traumatic Depressive Disorder Bipolar Disorder Personality Disorders Schizophrenia Psychotic Disorders

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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All patients admitted to a psychiatric acute ward

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Admission to the adult acute psychiatric ward of a certain geographical area during the study period

Exclusion Criteria

* Patients that do not agree to participate in the study
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Olavs Hospital

OTHER

Sponsor Role collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Solveig K Reitan, MD, PhD

Role: STUDY_CHAIR

St Olavs Hospital/NTNU

Locations

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St Olavs Hospital, Department of Psychiatry, Østmarka Hospital

Trondheim, Middle Norway, Norway

Site Status

Countries

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Norway

References

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Saether SG, Schou M, Stoecker W, Teegen B, Borowski K, Vaaler A, Kondziella D, Reitan SK. Onconeural Antibodies in Acute Psychiatric Inpatient Care. J Neuropsychiatry Clin Neurosci. 2017 Winter;29(1):74-76. doi: 10.1176/appi.neuropsych.16050110. Epub 2016 Aug 31.

Reference Type RESULT
PMID: 27578448 (View on PubMed)

Schou M, Saether SG, Borowski K, Teegen B, Kondziella D, Stoecker W, Vaaler A, Reitan SK. Prevalence of serum anti-neuronal autoantibodies in patients admitted to acute psychiatric care. Psychol Med. 2016 Dec;46(16):3303-3313. doi: 10.1017/S0033291716002038. Epub 2016 Sep 9.

Reference Type RESULT
PMID: 27609625 (View on PubMed)

Sakai Y, Iversen V, Reitan SK. FT4 and TSH, relation to diagnoses in an unselected psychiatric acute-ward population, and change during acute psychiatric admission. BMC Psychiatry. 2018 Jul 28;18(1):244. doi: 10.1186/s12888-018-1819-3.

Reference Type DERIVED
PMID: 30055589 (View on PubMed)

Other Identifiers

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94463

Identifier Type: -

Identifier Source: org_study_id

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