Biomagnetic Signals of Intestinal Ischemia II

NCT ID: NCT00179036

Last Updated: 2017-04-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

17 participants

Study Classification

OBSERVATIONAL

Study Start Date

2000-01-31

Study Completion Date

2015-12-31

Brief Summary

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The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify abnormalities without surgical intervention.

Detailed Description

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The electrical activity of the small intestine may contain important information that will help us diagnose gastrointestinal diseases. The major impediment to reducing mortality of mesenteric ischemia is the lack of a noninvasive diagnostic test that identifies the syndrome before extensive necrosis occurs. Mesenteric ischemia is caused by the lack of blood flow to the intestine. The Superconducting QUantum Interference Device (SQUID) measures the magnetic field of the intestinal smooth muscle. By comparing normal smooth muscle and that of patients with mesenteric ischemia, the investigators hope to identify abnormal disease states without surgery.

Conditions

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Ischemia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Good blood flow

Group without any ischemia to the small intestine

No interventions assigned to this group

Poor blood flow

Group with partial ischemia to the small intestine

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Normal subjects and those with diagnosed mesenteric ischemia

Exclusion Criteria

* Subjects who report a tendency toward claustrophobia
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

Vanderbilt University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Alan Bradshaw

Research Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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William O. Richards, MD

Role: PRINCIPAL_INVESTIGATOR

Vanderbilt University Medical Center

Locations

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Vanderbilt University Medical Center

Nashville, Tennessee, United States

Site Status

Countries

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United States

References

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Somarajan S, Muszynski ND, Cheng LK, Bradshaw LA, Naslund TC, Richards WO. Noninvasive biomagnetic detection of intestinal slow wave dysrhythmias in chronic mesenteric ischemia. Am J Physiol Gastrointest Liver Physiol. 2015 Jul 1;309(1):G52-8. doi: 10.1152/ajpgi.00466.2014. Epub 2015 Apr 30.

Reference Type DERIVED
PMID: 25930082 (View on PubMed)

Other Identifiers

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R01DK058197

Identifier Type: NIH

Identifier Source: secondary_id

View Link

060426

Identifier Type: -

Identifier Source: org_study_id

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