Subthalamic Nucleus (STN) Stimulation and Obsessive-Compulsive Disorder (OCD)
NCT ID: NCT00169377
Last Updated: 2018-03-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1/PHASE2
16 participants
INTERVENTIONAL
2005-10-31
2007-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
QUADRUPLE
Study Groups
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Group A
Deep brain stimulation on followed by off
deep brain stimulation
Stimulator on followed by off
No stimulation
Stimulator off followed by on
Group B
No stimulation, deep brain stimulation off followed by on
deep brain stimulation
Stimulator on followed by off
No stimulation
Stimulator off followed by on
Interventions
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deep brain stimulation
Stimulator on followed by off
No stimulation
Stimulator off followed by on
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Severe cognitive or behavioral disorders
18 Years
60 Years
ALL
No
Sponsors
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Assistance Publique - Hôpitaux de Paris
OTHER
Marie-laure Welter
OTHER
Responsible Party
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Marie-laure Welter
MD, PhD
Principal Investigators
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Luc Mallet, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Assistance Publique - Hôpitaux de Paris
Locations
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Bordeaux, , France
Clermont-Ferrand, , France
Grenoble, , France
Nantes, , France
Nice, , France
Centre d'Investigation Clinique-Hôpital Pitié-Salpêtrière
Paris, , France
Saint-Anne
Paris, , France
Poitiers, , France
Rennes, , France
Toulouse, , France
Countries
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References
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Le Jeune F, Verin M, N'Diaye K, Drapier D, Leray E, Du Montcel ST, Baup N, Pelissolo A, Polosan M, Mallet L, Yelnik J, Devaux B, Fontaine D, Chereau I, Bourguignon A, Peron J, Sauleau P, Raoul S, Garin E, Krebs MO, Jaafari N, Millet B; French Stimulation dans le trouble obsessionnel compulsif (STOC) study group. Decrease of prefrontal metabolism after subthalamic stimulation in obsessive-compulsive disorder: a positron emission tomography study. Biol Psychiatry. 2010 Dec 1;68(11):1016-22. doi: 10.1016/j.biopsych.2010.06.033. Epub 2010 Oct 16.
Bourredjem A, Pelissolo A, Rotge JY, Jaafari N, Machefaux S, Quentin S, Bui E, Bruno N, Pochon JB, Polosan M, Baup N, Papetti F, Chereau I, Arbus C, Mallet L, du Montcel ST; French "Stimulation dans le Trouble Obsessionnel Compulsif (STOC)" Study Group. A video Clinical Global Impression (CGI) in obsessive compulsive disorder. Psychiatry Res. 2011 Mar 30;186(1):117-22. doi: 10.1016/j.psychres.2010.06.021. Epub 2011 Feb 12.
Mallet L, Polosan M, Jaafari N, Baup N, Welter ML, Fontaine D, du Montcel ST, Yelnik J, Chereau I, Arbus C, Raoul S, Aouizerate B, Damier P, Chabardes S, Czernecki V, Ardouin C, Krebs MO, Bardinet E, Chaynes P, Burbaud P, Cornu P, Derost P, Bougerol T, Bataille B, Mattei V, Dormont D, Devaux B, Verin M, Houeto JL, Pollak P, Benabid AL, Agid Y, Krack P, Millet B, Pelissolo A; STOC Study Group. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med. 2008 Nov 13;359(20):2121-34. doi: 10.1056/NEJMoa0708514.
Other Identifiers
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P030422
Identifier Type: -
Identifier Source: org_study_id
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