Accelerated Continue Theta-burst Stimulation (acTBS)Treatment for Obsessive Compulsive Disease
NCT ID: NCT05221632
Last Updated: 2023-04-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2021-03-01
2023-07-01
Brief Summary
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Detailed Description
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Before the TMS treatment, Y-BOCS, Obsessions Symptom Scale revised (OCI-R), Hamilton Depression Scale (HAMD-17) and Hamilton Anxiety Scale (HAMA-14) were obtained by a trained investigator to assess baseline severity and other symptoms. The patients had receiving a battery measure of neuropsychological tests (standardized tests to investigate their cognitive problems, anxiety and depressive symptoms in daily life), magnetic resonance imaging scan in multimodalities。
After the last treatment, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), OCI-R, HAMD-17 and HAMA-14 were obtained, as well as the Global Index of Safety to assess adverse events of the treatment. Patients were instructed to focus their answers on the past 5 days.The patients had also receiving a battery measure of neuropsychological tests and magnetic resonance imaging scan in multimodalities.
Participants were interviewed for two and four weeks after their last treatment to obtain a Y-BOCS score, and they were asked to focus their answers on the past week.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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accelerated continue theta-burst stimulation
Fifty intermittent TBS sessions (1800 pulses per session, 50 minute inter-session interval ) were delivered as ten daily sessions over five consecutive days at 80% resting motor threshold (RMT). The MRI data set should be collected before the first cTBS session and after the last cTBS session.
Accelerated transcranial magnetic stimulation with real coil
The stimulation mode of TMS is accelerated continue theta-burst stimulation.
1-HZ repetition transcranial magnetic stimulation Stimulation
The repetition transcranial magnetic stimulation(rTMS) lasted 30 mins and delivered at 1 Hz with 1s duration, a total of 1800 pulses at 80% of the rest motor threshold (RMT) . MRI dataset should be acquired before the first rTMS session and after the last rTMS session.
Transcranial magnetic stimulation with real coil
The stimulation mode of TMS is 1-Hz repetitive Transcranial magnetic stimulation .
accelerated continue theta-burst stimulation (sham)
Fifty intermittent TBS sessions (1800 pulses per session, 50 minute inter-session interval ) were delivered as ten daily sessions over five consecutive days at 80% resting motor threshold (RMT). The MRI data set should be collected before the first cTBS session and after the last rTMS session. No actual magnetic stimulation was applied on the head of the volunteers. MRI dataset should be acquired before the first cTBS session and after the last cTBS session.
Transcranial magnetic stimulation with sham coil
The stimulation mode of TMS is accelerated continue theta-burst stimulation, but without active stimulation.
Interventions
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Accelerated transcranial magnetic stimulation with real coil
The stimulation mode of TMS is accelerated continue theta-burst stimulation.
Transcranial magnetic stimulation with real coil
The stimulation mode of TMS is 1-Hz repetitive Transcranial magnetic stimulation .
Transcranial magnetic stimulation with sham coil
The stimulation mode of TMS is accelerated continue theta-burst stimulation, but without active stimulation.
Eligibility Criteria
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Inclusion Criteria
* Voluntarily participated and cooperated with the experiment.
Exclusion Criteria
* Alcohol or drug abuse.
* Organic brain defects on T1 or T2 images.
* History of seizures or unexplained loss of consciousness.
* Family history of medication refractory epilepsy.
* Recent aggression or other forms of behavioral dyscontrol.
18 Years
45 Years
ALL
No
Sponsors
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Anhui Medical University
OTHER
Responsible Party
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Chunyan Zhu
A/Prof.
Locations
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Anhui Medical University
Hefei, Anhui, China
Countries
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Central Contacts
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Facility Contacts
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References
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Jiang J, Wan K, Liu Y, Tang Y, Tang W, Liu J, Ma J, Xue C, Chen L, Qian H, Liu D, Shen X, Fan R, Wang Y, Wang K, Ji G, Zhu C. A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive-Compulsive Disorder. Neural Plast. 2023 Dec 7;2023:2741287. doi: 10.1155/2023/2741287. eCollection 2023.
Other Identifiers
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precise high-dose OCD
Identifier Type: -
Identifier Source: org_study_id
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