Effects of Vitamin D Supplementation on Antimycobacterial Immunity

NCT ID: NCT00157066

Last Updated: 2007-01-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

230 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-12-31

Study Completion Date

2006-09-30

Brief Summary

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The purpose of this study is to determine how vitamin D supplementation (ergocalciferol) affects the immune response to mycobacterial infection.

Detailed Description

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Conditions

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Tuberculosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

DOUBLE

Interventions

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Ergocalciferol

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult
* Tuberculosis (TB) contact or TB patient

Exclusion Criteria

* Pregnancy
* Breastfeeding
* Hyperparathyroidism
* Sarcoidosis
* Renal failure
* HIV infection
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Imperial College London

OTHER

Sponsor Role collaborator

University of Cape Town

OTHER

Sponsor Role collaborator

Newham Chest Clinic, London E7 8QP, UK

UNKNOWN

Sponsor Role collaborator

Northwick Park Hospital, Harrow, UK

OTHER

Sponsor Role collaborator

Department of Clinical Biochemistry, Homerton Hospital, London E9 6SR, UK

OTHER

Sponsor Role collaborator

Environmental Health Department, London Borough of Newham, London E15 4SF, UK

UNKNOWN

Sponsor Role collaborator

Wellcome Trust

OTHER

Sponsor Role collaborator

Barts & The London NHS Trust

OTHER

Sponsor Role lead

Principal Investigators

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Adrian R Martineau, B Med Sci, MBBS, DTM&H, MRCP

Role: PRINCIPAL_INVESTIGATOR

Centre for Health Sciences, Barts and The London, QMUL

Locations

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Tuberculosis Clinic, Newham Chest Clinic

London, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ. A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med. 2007 Jul 15;176(2):208-13. doi: 10.1164/rccm.200701-007OC. Epub 2007 Apr 26.

Reference Type DERIVED
PMID: 17463418 (View on PubMed)

Other Identifiers

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AM1

Identifier Type: -

Identifier Source: org_study_id

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