A Randomised Trial to Evaluate the Antiviral Efficacy and Safety of Treatment With 500 mg Tipranavir (TPV) Plus 100 mg or 200 mg Ritonavir (RTV) p.o. BID in Comparison to 400 mg Lopinavir (LPV) Plus 100 mg RTV p.o. BID in Combination With Standard Background Regimen in ARV Therapy naïve Patients.

NCT ID: NCT00144105

Last Updated: 2013-11-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE2

Total Enrollment

562 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-02-29

Brief Summary

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Evaluation of safety and efficacy of Tipranavir (TPV) boosted with Ritonavir (RTV) versus an active control arm (Lopinavir / RTV) in antiretroviral (ARV) therapy naïve HIV-1 infected patients

Detailed Description

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Conditions

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HIV Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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TPV500mg/RTV200mgBID

Intervention Type DRUG

TPV500mg/RTV100mgBID

Intervention Type DRUG

LPV400mg/RTV100mgBID

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Signed informed consent prior to trial participation.
2. HIV-1 infected males or females \>= 18 years of age.
3. No previous ARV therapy.
4. Any CD4+ T lymphocyte count \< 500 cells / µl.
5. HIV-1 viral load \>= 5000 copies/mL at screening.
6. Screening laboratory values that indicate adequate baseline organ function.
7. A prior AIDS defining event is acceptable as long as it has resolved or the subject has been on stable treatment (e.g. opportunistic infection; no ARV) for at least 2 weeks before screening

Exclusion Criteria

1. Female patients of child-bearing potential who:

* have a positive serum pregnancy test at screening or during the study,
* are breast feeding,
* are planning to become pregnant
2. Use of investigational medications within 30 days before study entry or during the trial
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Principal Investigators

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Boehringer Ingelheim Study Coordinator

Role:

Locations

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Boehringer Ingelheim Investigational Site

BsAs, , Argentina

Site Status

Fundacion Huesped

Buenos Aires, , Argentina

Site Status

Hospital de Agudos Teodoro Alvarez

Buenos Aires, , Argentina

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Hospital Posadas

Haedo, , Argentina

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Boehringer Ingelheim Investigational Site

Darlinghurst, New South Wales, Australia

Site Status

St Vincents Hospital;

Darlinghurst, New South Wales, Australia

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Boehringer Ingelheim Investigational Site

Liverpool, New South Wales, Australia

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Boehringer Ingelheim Investigational Site

Surry Hills, New South Wales, Australia

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Boehringer Ingelheim Investigational Site

Carlton, Victoria, Australia

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Alfred Hospital

Melbourne, Victoria, Australia

Site Status

Boehringer Ingelheim Investigational Site

South Yarra, Victoria, Australia

Site Status

Unidade de Pesquisa Clínica (UPC) - AIDS

Campinas - Sp, , Brazil

Site Status

Boehringer Ingelheim Investigational Site

Curitiba - PR, , Brazil

Site Status

Boehringer Ingelheim Investigational Site

Manguinhos - Rio de Janeiro - RJ, , Brazil

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Instituto de Crianca / Hospital das Clínicas-FMUSP

Mooca / São Paulo, , Brazil

Site Status

Hospital Geral de Nova Iguaçu - Ministério da Saúde

Nova Iguaçu - RJ, , Brazil

Site Status

Universidade Federal do Rio de Janeiro

Rio de Janeiro - RJ, , Brazil

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Hospital Dia

Sacoma - São Paulo, , Brazil

Site Status

Universidade Federal da Bahia-Unidade Docente Assistencial d

Salvador - BA, , Brazil

Site Status

Boehringer Ingelheim Investigational Site

Santos - Sp, , Brazil

Site Status

Hospital do Servidor Público Estadual de São Paulo

São Paulo - Sp, , Brazil

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I.I. Emilio Ribas - Moléstias Infecciosas

São Paulo - SP, , Brazil

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Instituto de Infectologia Emílio Ribas

São Paulo - SP, , Brazil

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UNIFESP/ Hospital São Paulo- Univers. Federal de São Paulo

São Paulo - Sp, , Brazil

Site Status

Centro de Referência e Treinamento - DST/AIDS

Vila Mariana - Sao Paulo, , Brazil

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Downtown Infectious Diseases Clinic

Vancouver, British Columbia, Canada

Site Status

Boehringer Ingelheim Investigational Site

Winnipeg, Manitoba, Canada

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McMaster University Medical Centre

Hamilton, Ontario, Canada

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The Ottawa Hospital Riverside Campus

Ottawa, Ontario, Canada

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Canadian Immunodeficiency Research Collaborative Inc.

Toronto, Ontario, Canada

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St. Michael's Hospital

Toronto, Ontario, Canada

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Sunnybrook & Woman's College Health Science Centre

Toronto, Ontario, Canada

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Toronto General Hospital

Toronto, Ontario, Canada

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Boehringer Ingelheim Investigational Site

Whitby, Ontario, Canada

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Montreal General Hospital - McGill University Health Centre

Monteal, Quebec, Canada

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Boehringer Ingelheim Investigational Site

Montreal, Quebec, Canada

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Montreal Chest Institute, McGill University Health Centre

Montreal, Quebec, Canada

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Boehringer Ingelheim Investigational Site

Bogotá, , Colombia

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Hôpital Jean Verdier

Bondy, , France

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Hôpital Bocage

Dijon, , France

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Hôpital Albert Michallon

La Tronche, , France

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Hop Hôtel Dieu

Lyon, , France

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Hôpital Gui de Chauliac

Montpellier, , France

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Hôpital Saint Antoine

Paris, , France

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Hôpital Bellevue

Saint-Etienne, , France

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Epimed GmbH

Berlin, , Germany

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Klinikum der Ruhr-Universität Bochum

Bochum, , Germany

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Universitätsklinik Köln

Cologne, , Germany

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Boehringer Ingelheim Investigational Site

Düsseldorf, , Germany

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Universitätsklinikum Düsseldorf

Düsseldorf, , Germany

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Universitätsklinikum Essen

Essen, , Germany

Site Status

ifi Studien und Projekte GbR

Hamburg, , Germany

Site Status

Medizinische Poliklinik

München, , Germany

Site Status

Hospital de Especialidades no. 25

Col. Morelos, Monterrey, N. L., , Mexico

Site Status

Hospital Juan I. Menchaca IMSS

Col. Villaseñor, Guadalajara, Jal., , Mexico

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Hospital Lopez Mateos

México, , Mexico

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Centre for AIDS Diagnostics and Therapy

Chorzów, , Poland

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Medical Academy of Szczecin

Szczecin, , Poland

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Hospital for Infectious Diseases

Warsaw, , Poland

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Department of Infectious Diseases

Wroclaw, , Poland

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Matei Bals Institute of Infectious Diseases

Bucharest, , Romania

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Victor Babes Clincial Hospital

Bucharest, , Romania

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Russian Federal Scientific

Moscow, , Russia

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City Hospital St Petersburg

Saint Petersburg, , Russia

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Boehringer Ingelheim Investigational Site

Badalona, , Spain

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Boehringer Ingelheim Investigational Site

Barcelona, , Spain

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Hospital Clínico y Provincial

Barcelona, , Spain

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Ciutat Sanitaria Universitaria de Bellvitge

Hospitalet de Llobregat (Barcelona), , Spain

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Boehringer Ingelheim Investigational Site

Madrid, , Spain

Site Status

Hospital 12 de octubre

Madrid, , Spain

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Hospital Ramón y Cajal

Madrid, , Spain

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Boehringer Ingelheim Investigational Site

Málaga, , Spain

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Boehringer Ingelheim Investigational Site

Santa Cruz de Tenerife, , Spain

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Hospital Universitario Vírgen del Rocío

Seville, , Spain

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Hospital Mútua de Terrasa

Terrassa, , Spain

Site Status

Ramathibodhi Hospital

Bangkok, , Thailand

Site Status

King Chulalonkorn Hospital

Pathumwan, Bangkok, , Thailand

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Princess Margaret Hospital

Nassau, , The Bahamas

Site Status

Boehringer Ingelheim Investigational Site

Edinburgh, , United Kingdom

Site Status

North Middlesex Hospital

London, , United Kingdom

Site Status

Royal Free Hospital

London, , United Kingdom

Site Status

Countries

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Argentina Australia Brazil Canada Colombia France Germany Mexico Poland Romania Russia Spain Thailand The Bahamas United Kingdom

Other Identifiers

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1182.33

Identifier Type: -

Identifier Source: org_study_id