Radial Artery Versus Saphenous Vein Patency (RSVP) Study

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

142 participants

Study Classification

INTERVENTIONAL

Study Start Date

1998-05-31

Study Completion Date

2006-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine whether the radial artery (artery in the arm) or saphenous vein (vein in the leg), when used as bypass grafts for coronary artery bypass surgery, have a greater patency rate (degree of opening)at 5 years after surgery.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Radial Artery Versus Saphenous Vein Patency (RSVP) Trial - 10 Year Follow-up

NCT01622387

Coronary Artery Disease

WITHDRAWN NA

Comparison of Saphenous Vein Graft Harvested From Upper Versus Lower Leg in Coronary Artery Bypass Grafting

NCT01974492

Triple Vessel Disease Unstable Angina Stable Angina +1 more

COMPLETED NA

Radial Artery Versus Saphenous Vein Grafts in Coronary Artery Bypass Surgery

NCT00054847

Cardiovascular Disease Coronary Artery Disease

COMPLETED NA

Radial Artery Patency and Clinical Outcomes Trial

NCT00475488

Coronary Artery Disease Atherosclerosis

UNKNOWN NA

Radial Artery Versus No-touch Saphenous Vein

NCT06014047

Coronary Artery Disease

NOT_YET_RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Arteries differ from veins both in morphology and physiology. Thus the way they behave as in vivo conduits when used in coronary artery bypass grafting is also likely to be different. This may partly explain the predisposition of veins used as coronary conduits to accelerated atherosclerosis in comparison with the internal mammary artery grafts. There are presently few data describing the properties of the radial artery as an in-vivo coronary conduit over the longer-term.

The study will compare angiographic patency of the radial artery or saphenous vein graft anastomosed to the native left circumflex coronary territory at 3 months and 5 years after surgery. A substudy will compare 5-year post-surgery diameter and blood flow of in-vivo radial artery and saphenous vein grafts in response to endothelium-dependent and non-endothelium-dependent stimuli when patients attend for their scheduled follow-up angiogram.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Coronary Arteriosclerosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Saphenous vein

Saphenous vein aortocoronary bypass graft

Group Type ACTIVE_COMPARATOR

Coronary artery bypass graft (CABG) surgery

Intervention Type PROCEDURE

Patients were randomized to receive either a radial artery or a long saphenous vein graft to the left circumflex coronary artery territory during CABG surgery

Radial artery

Radial artery aortocoronary bypass graft

Group Type EXPERIMENTAL

Coronary artery bypass graft (CABG) surgery

Intervention Type PROCEDURE

Patients were randomized to receive either a radial artery or a long saphenous vein graft to the left circumflex coronary artery territory during CABG surgery

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Coronary artery bypass graft (CABG) surgery

Patients were randomized to receive either a radial artery or a long saphenous vein graft to the left circumflex coronary artery territory during CABG surgery

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* on waiting list for clinically-indicated myocardial revascularization surgery
* aged 40-70 years
* significant stenosis (≥70%) in the circumflex territory as identified on preoperative angiograms
* negative Allen's test (defined as the return of palmar circulation within 5 seconds of releasing ulnar artery compression)
* willing to give written informed consent

Exclusion Criteria

* poor left ventricular (LV) function (LV ejection fraction \<25%)
* severe diffuse peripheral vascular disease or bilateral varicose venous disease
* inability to comply with the angiographic follow-up at 3 months or/and 5 years

Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No