Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

NCT ID: NCT01118468

Last Updated: 2017-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Study Completion Date

2019-12-31

Brief Summary

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Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts "competes" with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.

Detailed Description

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Conditions

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Coronary Artery Bypass

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients with previous coronary artery bypass grafts undergoing coronary angiography and graft restudy

Exclusion Criteria

* Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
* Unable to consent
* Contraindications to adenosine
* Contraindications to cardiac MRI
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Imperial College London

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Justin E Davies, MRCP PhD

Role: PRINCIPAL_INVESTIGATOR

Imperial College London

Locations

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Imperial College NHS Trust

London, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Justin E Davies, MRCP, PhD

Role: CONTACT

020 7594 33 86

Sayan Sen, MRCP

Role: CONTACT

020 7594 33 86

Facility Contacts

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Justin E Davies, MRCP, PhD

Role: primary

020 7594 33 86

Sayan Sen

Role: backup

020 7594 33 86

Other Identifiers

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1426

Identifier Type: -

Identifier Source: org_study_id

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