Socioeconomic Patterning of Inflammation and Hemostasis - Ancillary to MESA

NCT ID: NCT00091494

Last Updated: 2016-04-11

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2004-09-30
• Study Completion Date: 2008-06-30

Brief Summary

To investigate how inflammation, hemostasis, and stress may contribute to neighborhood and individual-level socioeconomic differences in cardiovascular risk.

Detailed Description

BACKGROUND:

In epidemiologic studies, associations of cardiovascular risk with individual and neighborhood socioeconomic characteristics tend to persist after adjustment for established cardiovascular risk factors suggesting that other mediators may be involved. However, evidence regarding what these mediators may be is largely absent. Elucidating the reasons for these persistent socioeconomic differences may enhance our ability to reduce these differentials and will contribute to our understanding of the causes of cardiovascular disease generally. Two biological processes, inflammation and hemostasis, have recently emerged as potentially important in the development of atherosclerosis and the precipitation of clinical cardiovascular events. Both processes have also been recently linked to psychosocial factors and stress. However, studies investigating social gradients in inflammation and hemostasis remain rare. In addition, the relation of psychosocial factors and biological markers of the stress response to inflammation and hemostasis have not been examined in large population-based studies.

DESIGN NARRATIVE:

The study is ancillary to the ongoing epidemiologic study of atherosclerosis, the Multi-Ethnic Study of Atherosclerosis (MESA). The project will collect data on stress hormones and follow- up measures of inflammation and hemostasis which are not part of the existing MESA protocol on a subsample of the cohort. The study will also collect additional data on neighborhood sources of stress for the subsample. The new data will be linked to existing MESA data.

Using newly collected data linked to the MESA, the study will investigate (1) associations of neighborhood and individual-level socioeconomic indicators with markers of inflammation and hemostasis; (2) associations of individual-level psychosocial factors and sources of chronic stress (at the individual and neighborhood level) with inflammatory markers and hemostasis; and (3) the relationship between biological markers of the stress response (such as cortisol and adrenaline/noradrenaline) and inflammation and hemostasis). Project aims will be achieved by linking MESA data to newly-collected data on neighborhood characteristics and biomarkers of inflammation, hemostasis and the stress response in MESA participants. The project is innovative in that it will span and link three levels: the social/environmental level (neighborhood characteristics and social position), the behavioral/psychological level (behavioral and psychosocial factors), and the biological level (inflammation, hemostasis, and stress hormones). The study will provide a unique opportunity to elucidate the links between socioeconomic factors, stress, inflammation and hemostasis in a large and diverse population-based sample.

Conditions

Atherosclerosis; Cardiovascular Diseases; Heart Diseases; Inflammation; Blood Coagulation Disorders

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

Participants at NY and LA MESA sites.

• Minimum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role: collaborator

University of Michigan

OTHER

Sponsor Role: lead

Principal Investigators

Ana Diez Roux

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Other Identifiers

R01HL076831

Identifier Type: NIH

Identifier Source: secondary_id

View Link

1268

Identifier Type: -

Identifier Source: org_study_id