Parkinson's Research: The Organized Genetics Initiative

NCT ID: NCT00086073

Last Updated: 2011-02-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1800 participants

Study Classification

OBSERVATIONAL

Study Start Date

1998-08-31

Study Completion Date

2011-01-31

Brief Summary

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The purpose of this trial is to study genetic and other risk factors that may be important in the development of Parkinson's disease.

Detailed Description

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The The Parkinson's Research: The Organized Genetics Initiative, also known as PROGENI, is a multi-center study involving 2000 people throughout North America who are affected, or possibly affected, with Parkinson's disease (PD). The goal of the initiative is to study the genetic and other risk factors which may be important in the development of PD.

In order to better understand the genetic factors leading to PD, researchers will study families having 2 or more members diagnosed with PD. Using DNA samples from each participant, researchers hope to identify genes that may cause a person to be at higher risk for developing PD.

Each participant in the study will be asked to complete a family history questionnaire, providing information about the history of PD in the family. Participants also will be asked to discuss the symptoms they have experienced and their responses to PD medications. This information will be used by study personnel to determine further eligibility for the study. Those eligible for further participation will be asked to undergo a study visit at the site closest to their residence, during which they will be asked to complete questionnaires regarding PD symptoms, medical history, places of residence, occupations, mood, mental status, and activity level. A blood sample will be drawn for DNA extraction. The study visit will take about 2 hours.

Conditions

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Parkinson Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* To be eligible to participate in this study participants must be diagnosed with or have symptoms of PD. In addition, they must also have a family history of PD in other relatives.

Exclusion Criteria

* Subjects cannot have participated in any other genetic research project for Parkinson's disease.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Parkinson Study Group

NETWORK

Sponsor Role collaborator

Children's Hospital Medical Center, Cincinnati

OTHER

Sponsor Role collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

Sponsor Role collaborator

Indiana University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Indiana University

Principal Investigators

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Tatiana Foroud, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Indiana University

Locations

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Barrow Neurological Institute

Phoenix, Arizona, United States

Site Status

Parkinson's & Movement Disorder Institute

Fountain Valley, California, United States

Site Status

University of California Irvine

Irvine, California, United States

Site Status

Pacific Neuroscience Medical Group, Inc

Oxnard, California, United States

Site Status

University of California San Diego

San Diego, California, United States

Site Status

University of California San Francisco

San Francisco, California, United States

Site Status

University of Colorado Health Sciences Center

Denver, Colorado, United States

Site Status

Colorado Neurological Institute

Englewood, Colorado, United States

Site Status

Institute for Neurodegenerative Disorders

New Haven, Connecticut, United States

Site Status

Parkinson's Disease & Mmvt Disorders Ctr of Boca Raton

Boca Raton, Florida, United States

Site Status

Mayo Clinic Jacksonville

Jacksonville, Florida, United States

Site Status

University of South Florida

Tampa, Florida, United States

Site Status

Cleveland Clinic Florida

Weston, Florida, United States

Site Status

Cleveland Clinic Florida

Weston, Florida, United States

Site Status

Medical College of Georgia

Augusta, Georgia, United States

Site Status

Pacific Health Research Institute

Honolulu, Hawaii, United States

Site Status

Northwestern University Medical School

Chicago, Illinois, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

Evanston Northwestern Healthcare

Evanston, Illinois, United States

Site Status

Southern Illinois Univ School of Medicine

Springfield, Illinois, United States

Site Status

Indiana University School of Medicine

Indianapolis, Indiana, United States

Site Status

University of Iowa

Iowa City, Iowa, United States

Site Status

Kansas University Medical Center

Kansas City, Kansas, United States

Site Status

Oschsner Clinic Foundation

New Orleans, Louisiana, United States

Site Status

LSU Health Sciences Center

Shreveport, Louisiana, United States

Site Status

Port City Neurology, Inc

Scarborough, Maine, United States

Site Status

University of Maryland School of Medicine

Baltimore, Maryland, United States

Site Status

Johns Hopkins University

Baltimore, Maryland, United States

Site Status

Brigham & Women's Hospital

Boston, Massachusetts, United States

Site Status

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Site Status

Michigan State University

East Lansing, Michigan, United States

Site Status

Henry Ford Health System

Southfield, Michigan, United States

Site Status

University of Minnesota Fairview Univ Med Ctr

Minneapolis, Minnesota, United States

Site Status

Washington University

St Louis, Missouri, United States

Site Status

Albany Medical College

Albany, New York, United States

Site Status

University of Buffalo

Buffalo, New York, United States

Site Status

Beth Israel Medical Center

New York, New York, United States

Site Status

Mount Sinai Medical Center

New York, New York, United States

Site Status

Columbia-Presbyterian Medical Center

New York, New York, United States

Site Status

University of Rochester Medical Center

Rochester, New York, United States

Site Status

Wake Forest University School of Medicine

Winston-Salem, North Carolina, United States

Site Status

University of Cincinnati Medical Center

Cincinnati, Ohio, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

Ohio State University

Columbus, Ohio, United States

Site Status

Medical College of Ohio, ,

Toledo, Ohio, United States

Site Status

Oregon Health & Science University

Portland, Oregon, United States

Site Status

University of Pittsburg

Pittsburgh, Pennsylvania, United States

Site Status

Neurohealth

Warwick, Rhode Island, United States

Site Status

University of Tennessee-Health Sciences Center

Memphis, Tennessee, United States

Site Status

UT Southwestern Medical Center

Dallas, Texas, United States

Site Status

Baylor College of Medicine

Houston, Texas, United States

Site Status

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

University of Alberta

Edmonton, Alberta, Canada

Site Status

London Health Sciences Center

London, Ontario, Canada

Site Status

Ottawa Civic Hospital

Ottawa, Ontario, Canada

Site Status

Toronto Western Hospital

Toronto, Ontario, Canada

Site Status

Hotel-Dieu Hospital-CHUM

Montreal, Quebec, Canada

Site Status

University of Puerto Rico School of Medicine

San Juan, , Puerto Rico

Site Status

Countries

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United States Canada Puerto Rico

Other Identifiers

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R01NS037167

Identifier Type: NIH

Identifier Source: secondary_id

View Link

9703-09

Identifier Type: -

Identifier Source: org_study_id

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