Retinal Function in Parkinson's Disease

NCT ID: NCT01010074

Last Updated: 2009-11-09

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2009-10-31
• Study Completion Date: 2010-12-31

Brief Summary

Parkinson's disease (PD) is a neurodegenerative disorder characterized by muscle rigidity, tremor, a slowing of physical movement (bradykinesia) and, in extreme cases, a loss of physical movement. The primary symptoms are the results of decreased stimulation of the motor cortex arising from the basal ganglia normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Secondary symptoms may include high level cognitive dysfunction and subtle language problems. Included in the symptomatology experienced by patients with PD, visual abnormalities are not uncommon. Visual changes among patients with PD appear not only dynamic in nature, but differentially affected based on the course of the disease and, perhaps more importantly, its treatment. Parkinson's disease has significant ramifications not only in observation of irregularities in vision, but how vision interacts with entrainment of the circadian clock. The purpose of this study is to examine the relationship between PD and operation of a unique set of retinal cells known to regulate the circadian clock and sleep-wake cycles in human subjects.

Conditions

Parkinson's Disease

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Exclusion Criteria

-

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 64 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

US Department of Veterans Affairs

FED

Sponsor Role: lead

Responsible Party

Hines VA Medical Center

Locations

Hines VA Medical Center

Hines, Illinois, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Bruce Ira Gaynes, OD, PharmD

Role: CONTACT

Bruce.Gaynes@va.gov

708-216-6262

Jasvinder Chawla, MD

Role: CONTACT

Jasvinder.Chawla@va.gov

708-202-3800

Facility Contacts

Bruce Ira Gaynes, OD, PharmD

Role: primary

Bruce.Gaynes@va.gov

708-216-6262

Other Identifiers

PD001

Identifier Type: -

Identifier Source: org_study_id