Spinal Reflexes in Motor Skill Learning

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

22 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-01-31

Study Completion Date

2005-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will test a spinal cord reflex called reciprocal inhibition before, during, and after learning a motor skill to see if the reflex becomes stronger by learning the movement. People learn new motor skills throughout their lives. At first, performing a new skilled movement such as riding a bicycle takes effort and is clumsy, but with practice, it becomes relatively automatic. The motor cortex (a part of the brain) is very active when a new skilled movement is learned, but becomes less active when the movement is over-learned. This study will determine whether the spinal cord helps coordinate the pattern of activity between groups of muscles once a motor skill is learned.

Healthy volunteers between 21 and 65 years of age may be eligible for this study. Candidates are screened with a medical history and neurological examination.

Participants are divided into two groups. Group 1 has movement training sessions only and Group 2 has both movement training sessions and physiology sessions, as follows:

Movement training sessions

For 15 minutes every weekday, participants practice moving their wrist back and forth to make a cursor on the computer screen follow a target. Activity of the arm muscles is monitored with surface electrodes taped to the skin. The sessions continue until the participant can perform the movement well. Group 1 participants return to the clinic a week after the last session to perform the movement again to see if their skill level has changed. Each session lasts about 20 to 30 minutes.

Physiology sessions

In three separate sessions, the reflex for reciprocal inhibition is measured before and at several times during the movement task. This is done with nerve conduction studies. A probe placed on the skin delivers a low-intensity electrical stimulus. Wires taped to the skin record the nerve impulses. To measure reciprocal inhibition, several dozen stimuli are given to two nerves in combinations. Each session lasts 2 to 3 hours.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Spinal Cord Plasticity

NCT00073606

Healthy

COMPLETED

Nerve Stimulation to Modify a Spinal Reflex

NCT00039819

Healthy

COMPLETED

Nervous System Function in Normal Volunteers During Cycling Training

NCT00055588

Healthy

COMPLETED PHASE1

Corticospinal Function After Spinal Cord Injury

NCT02451683

Spinal Cord Injury

RECRUITING NA

Neurostimulation for Respiratory Function After Spinal Cord Injury

NCT05756894

Spinal Cord Injuries Cervical Spinal Cord Injury Respiratory Function Impaired

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Objective:

Once a skilled movement is thoroughly learned, it can be performed relatively automatically. The motor cortex is active when learning a new motor skill, but becomes less activated once the skill has become over-learned. We hypothesize that learning a skilled movement is associated with more efficient use of subcortical motor circuits. Subcortical motor circuits can coordinate features of the intended movement such as the timing and patterns of activation of different muscles. The goal of this study is to determine whether learning a motor skill strengthens spinal interneuron circuits that facilitate the movement. Subjects will learn to perform a movement consisting of alternating wrist movements. The strength of reciprocal inhibition between antagonist muscles will be tested.

Study Population:

22 healthy adult volunteers

Design:

The study has two experiments. Both experiments use a within-subjects design. The purpose of the first experiment is to determine whether learning to accurately perform an alternating wrist flexion and extension movement task is associated with reduced co-contraction of wrist flexor and extensor muscles. Subjects will practice making accurate wrist flexions and extensions to keep a cursor on a target for fifteen-minute sessions every weekday until they are able to obtain 95% accuracy. Activity of the arm muscles will be monitored during the sessions with surface electrodes on the arm muscles. The first experiment will also determine the best training parameters for learning the task. In the second experiment, a second group of subjects will learn the task using the best training parameters. The strength of the reflex for reciprocal inhibition will be measured before, during and after training. Reciprocal inhibition will also be measured after the movement has become highly learned.

Outcome measures:

In the first experiment, the outcome will be the percent of movement time in which co-contraction occurs, as recorded from surface electrodes, while the subject learns to perform the movement to 95% accuracy. In the second experiment, the outcome measure is the strength of spinally mediated reciprocal inhibition, as measured using reflexes.