The Evaluation of the Efficacy and Tolerability of FASLODEX (Fulvestrant) and AROMASIN (Exemestane) in Hormone Receptor Positive Postmenopausal Women With Advanced Breast Cancer

NCT ID: NCT00065325

Last Updated: 2015-02-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

694 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-08-31

Study Completion Date

2014-09-30

Brief Summary

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The purpose of this study is to compare the efficacy of Faslodex (fulvestrant) to Aromasin (exemestane) in hormone receptor positive postmenopausal women with advanced breast cancer. Patients will be treated until disease progression or until the investigator has determined that treatment is not in the best interest of the patient, whichever occurs first.

Detailed Description

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Conditions

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Locally Advanced Breast Cancer Metastatic Breast Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Exemestane

Group Type ACTIVE_COMPARATOR

Exemestane

Intervention Type DRUG

oral capsule

2

Fulvestrant

Group Type EXPERIMENTAL

Fulvestrant

Intervention Type DRUG

intramuscular injection

Interventions

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Fulvestrant

intramuscular injection

Intervention Type DRUG

Exemestane

oral capsule

Intervention Type DRUG

Other Intervention Names

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Faslodex ZD9238 AROMASIN™

Eligibility Criteria

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Inclusion Criteria

* Biopsy confirmation of Breast Cancer
* Breast Cancer has continued to grow after having received treatment with an aromatase inhibitor
* Postmenopausal women defined as a women who has stopped having menstrual periods
* Evidence of hormone sensitivity
* Written informed consent to participate in the trial

Exclusion Criteria

* Previous treatment with Faslodex (fulvestrant) or Aromasin (exemestane)
* Any hormonal therapy used to modify the course of an additional medical condition after prior treatment with a non-steroidal aromatase inhibitor
* Treatment with an investigational or non-approved drug within one month
* An existing serious disease, illness, or condition that will prevent participation or compliance with study procedures
* A history of allergies to any active or inactive ingredients of Faslodex or Exemestane (i.e. castor oil or Mannitol)
Minimum Eligible Age

32 Years

Maximum Eligible Age

91 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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AstraZeneca Faslodex Medical Science Director, MD

Role: STUDY_DIRECTOR

AstraZeneca

Locations

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Birmingham, Alabama, United States

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Arcadia, California, United States

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Fountain Valley, California, United States

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Laverne, California, United States

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Long Beach, California, United States

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Santa Rosa, California, United States

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Torrington, Connecticut, United States

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Washington D.C., District of Columbia, United States

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Boca Raton, Florida, United States

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Gainesville, Florida, United States

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Jacksonville, Florida, United States

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Miami, Florida, United States

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New Port Richey, Florida, United States

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Pensacola, Florida, United States

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Athens, Georgia, United States

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Chicago, Illinois, United States

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Harvey, Illinois, United States

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Springfield, Illinois, United States

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Iowa City, Iowa, United States

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Overland Park, Kansas, United States

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Baton Rouge, Louisiana, United States

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Metairie, Louisiana, United States

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New Orleans, Louisiana, United States

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Shreveport, Louisiana, United States

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Bangor, Maine, United States

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Baltimore, Maryland, United States

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Frederick, Maryland, United States

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Kalamazoo, Michigan, United States

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Royal Oak, Michigan, United States

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Saint Joseph, Michigan, United States

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Hooksett, New Hampshire, United States

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Livingston, New Jersey, United States

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Voorhees Township, New Jersey, United States

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Albuquerque, New Mexico, United States

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Charlotte, North Carolina, United States

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Durham, North Carolina, United States

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Canton, Ohio, United States

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Hershey, Pennsylvania, United States

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Lancaster, Pennsylvania, United States

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Langhorne, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Providence, Rhode Island, United States

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Columbia, South Carolina, United States

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Greenville, South Carolina, United States

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Spartenburg, South Carolina, United States

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Austin, Texas, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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San Antonio, Texas, United States

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Burlington, Vermont, United States

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Richmond, Virginia, United States

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Buenos Aires, Buenos Aires, Argentina

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Ciudad de Buenos Aires, Buenos Aires, Argentina

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Mar del Plata, Buenos Aires, Argentina

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Rosario, Santa Fe Province, Argentina

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Brussels, Belgium, Belgium

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Leuven, Belgium, Belgium

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Ottignies, Belgium, Belgium

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Wilrijk, Belgium, Belgium

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Goiânia, Goiás, Brazil

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Rio de Janeiro, Rio de Janeiro, Brazil

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Porto Alegre, Rio Grande do Sul, Brazil

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São Paulo, São Paulo, Brazil

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Edmonton, Alberta, Canada

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Penticton, British Columbia, Canada

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Vancouver, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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St. John's, Newfoundland and Labrador, Canada

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Kingston, Ontario, Canada

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London, Ontario, Canada

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Newmarket, Ontario, Canada

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Oshawa, Ontario, Canada

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Ottawa, Ontario, Canada

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Sault Ste. Marie, Ontario, Canada

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Toronto, Ontario, Canada

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Windsor, Ontario, Canada

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Montreal, Quebec, Canada

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Québec, Quebec, Canada

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Aalborg, , Denmark

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Herning, , Denmark

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Hillerød, , Denmark

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København Ø, , Denmark

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Roskilde, , Denmark

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Sønderborg, , Denmark

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Bordeaux, , France

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Lille, , France

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Montpellier, , France

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Vandœuvre-lès-Nancy, , France

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Augsburg, , Germany

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Berlin, , Germany

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Hamburg, , Germany

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Regensburg, , Germany

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Budapest, , Hungary

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Debrecen, , Hungary

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Szeged, , Hungary

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Haifa, , Israel

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Tel Aviv, , Israel

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Obninsk, Kaluga Oblast, Russia

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Moscow, , Russia

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Saint Petersburg, , Russia

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Klerksdorp, North West, South Africa

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Bloemfontein, South Africa, South Africa

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Cape Town, South Africa, South Africa

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Johannesburg, South Africa, South Africa

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Port Elizabeth, South Africa, South Africa

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Pretoria, South Africa, South Africa

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Seville, Andalusia, Spain

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Barcelona, Catalonia, Spain

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Hospitalet Dellobregat(barcelo, Catalonia, Spain

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Terrassa(barcelona), Catalonia, Spain

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Madrid, Madrid, Spain

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Valencia, Valencia, Spain

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Halmstad, , Sweden

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Lund, , Sweden

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Stockholm, , Sweden

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Uppsala, , Sweden

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Nottingham, , United Kingdom

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Countries

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United States Argentina Belgium Brazil Canada Denmark France Germany Hungary Israel Russia South Africa Spain Sweden United Kingdom

References

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Arizmendi C, Zhu Y, Khan M, Gable J, Reeve BB, King-Kallimanis B, Bell J. The FACT-GP5 as a global tolerability measure: responsiveness and robustness to missing assessments. Qual Life Res. 2024 Oct;33(10):2869-2880. doi: 10.1007/s11136-024-03740-x. Epub 2024 Jul 24.

Reference Type DERIVED
PMID: 39046616 (View on PubMed)

Related Links

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Other Identifiers

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EFECT

Identifier Type: -

Identifier Source: secondary_id

D6997C00048

Identifier Type: -

Identifier Source: secondary_id

9238IL/0048

Identifier Type: -

Identifier Source: org_study_id

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