Comparison of Fulvestrant (FASLODEX™) 250 mg and 500 mg in Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing After Previous Endocrine Therapy.

NCT ID: NCT00099437

Last Updated: 2025-09-24

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

736 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-02-13

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the efficacy of a new dose of 500 mg Fulvestrant with the standard dose of 250 mg in postmenopausal women with oestrogen receptor positive advanced breast cancer who have failed on a previous endocrine treatment.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Breast Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Fulvestrant 500 mg

Group Type EXPERIMENTAL

Fulvestrant

Intervention Type DRUG

intramuscular injection

2

Fulvestrant 250 mg

Group Type EXPERIMENTAL

Fulvestrant

Intervention Type DRUG

intramuscular injection

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Fulvestrant

intramuscular injection

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Faslodex ZD9238

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Breast Cancer has continued to grow after having received treatment with an anti-estrogen hormonal treatment such as tamoxifen or an aromatase inhibitor
* Requiring hormonal treatment
* Postmenopausal women defined as a woman who has stopped having menstrual periods
* Evidence of positive estrogen receptor hormone sensitivity
* Written informed consent to participate in the trial

Exclusion Criteria

* Treatment with an investigational or non-approved drug within one month
* An existing serious disease, illness, or condition that will prevent participation or compliance with study procedures
* A history of allergies to any active or inactive ingredients of Faslodex (i.e. castor oil)
* Treatment with more than one regimen of chemotherapy for advanced breast cancer
* Treatment with more than one regimen of hormonal treatment for advanced breast cancer
Minimum Eligible Age

45 Years

Maximum Eligible Age

130 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Faslodex Medical Science Director, MD

Role: STUDY_DIRECTOR

AstraZeneca

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Research Site

Casa Grande, Arizona, United States

Site Status

Research Site

Fountain Valley, California, United States

Site Status

Research Site

New Britain, Connecticut, United States

Site Status

Research Site

Crystal River, Florida, United States

Site Status

Research Site

Fort Lauderdale, Florida, United States

Site Status

Research Site

Urbana, Illinois, United States

Site Status

Research Site

Rosedale, Maryland, United States

Site Status

Research Site

Detroit, Michigan, United States

Site Status

Research Site

Kansas City, Missouri, United States

Site Status

Research Site

St Louis, Missouri, United States

Site Status

Research Site

Voorhees Township, New Jersey, United States

Site Status

Research Site

Greenville, North Carolina, United States

Site Status

Research Site

Pasadena, Texas, United States

Site Status

Research Site

West Bend, Wisconsin, United States

Site Status

Research Site

Brasschaat, , Belgium

Site Status

Research Site

Brussels, , Belgium

Site Status

Research Site

Brussels, , Belgium

Site Status

Research Site

Edegem, , Belgium

Site Status

Research Site

Ghent, , Belgium

Site Status

Research Site

Hasselt, , Belgium

Site Status

Research Site

Liège, , Belgium

Site Status

Research Site

Turnhout, , Belgium

Site Status

Research Site

Barretos, , Brazil

Site Status

Research Site

Londrina, , Brazil

Site Status

Research Site

Porto Alegre, , Brazil

Site Status

Research Site

Recife, , Brazil

Site Status

Research Site

Salvador, , Brazil

Site Status

Research Site

São Paulo, , Brazil

Site Status

Research Site

Antofagasta, , Chile

Site Status

Research Site

Santiago, , Chile

Site Status

Research Site

Santiago, , Chile

Site Status

Research Site

Bogotá, , Colombia

Site Status

Research Site

Cali, , Colombia

Site Status

Research Site

Brno, , Czechia

Site Status

Research Site

České Budějovice, , Czechia

Site Status

Research Site

Pardubice, , Czechia

Site Status

Research Site

Prague, , Czechia

Site Status

Research Site

Prague, , Czechia

Site Status

Research Site

Prague, , Czechia

Site Status

Research Site

Tábor, , Czechia

Site Status

Research Site

V Uvalu 84, , Czechia

Site Status

Research Site

Nyíregyháza, , Hungary

Site Status

Research Site

Székesfehérvár, , Hungary

Site Status

Research Site

Szombathely, , Hungary

Site Status

Research Site

Ansārinagar, , India

Site Status

Research Site

Bhopal, , India

Site Status

Research Site

Hyderabad, , India

Site Status

Research Site

Jaipur, , India

Site Status

Research Site

Kolkata, , India

Site Status

Research Site

Manipal, , India

Site Status

Research Site

Marg Jaipur, , India

Site Status

Research Site

Mumbai, , India

Site Status

Research Site

Pune, , India

Site Status

Research Site

Trivandrum, , India

Site Status

Research Site

Vellore, , India

Site Status

Research Site

Aviano, , Italy

Site Status

Research Site

Bergamo, , Italy

Site Status

Research Site

Carpi, , Italy

Site Status

Research Site

Genova, , Italy

Site Status

Research Site

Prato, , Italy

Site Status

Research Site

Reggio Emilia, , Italy

Site Status

Research Site

Varese, , Italy

Site Status

Research Site

Floriana, , Malta

Site Status

Research Site

Mexico City, , Mexico

Site Status

Research Site

México, , Mexico

Site Status

Research Site

México, , Mexico

Site Status

Research Site

Bialystok, , Poland

Site Status

Research Site

Lodz, , Poland

Site Status

Research Site

Poznan, , Poland

Site Status

Research Site

Ivanovo, , Russia

Site Status

Research Site

Kazan, Tatarstan, , Russia

Site Status

Research Site

Kazan, Tatarstan, , Russia

Site Status

Research Site

Krasnodar, , Russia

Site Status

Research Site

Lipetsk, , Russia

Site Status

Research Site

Moscow, , Russia

Site Status

Research Site

Moscow, , Russia

Site Status

Research Site

Moscow, , Russia

Site Status

Research Site

Moscow, , Russia

Site Status

Research Site

Nizhny Novgorod, , Russia

Site Status

Research Site

Obninsk, , Russia

Site Status

Research Site

Ryazan, , Russia

Site Status

Research Site

Saint Petersburg, , Russia

Site Status

Research Site

Saint Petersburg, , Russia

Site Status

Research Site

Saint Petersburg, , Russia

Site Status

Research Site

Yaroslavl, , Russia

Site Status

Research Site

Bardejov, , Slovakia

Site Status

Research Site

Bratislava, , Slovakia

Site Status

Research Site

Nitra, , Slovakia

Site Status

Research Site

Trnava, , Slovakia

Site Status

Research Site

A Coruña, , Spain

Site Status

Research Site

Madrid, , Spain

Site Status

Research Site

Málaga, , Spain

Site Status

Research Site

Oviedo, , Spain

Site Status

Research Site

Salamanca, , Spain

Site Status

Research Site

Seville, , Spain

Site Status

Research Site

Cherkasy, , Ukraine

Site Status

Research Site

Dnipro, , Ukraine

Site Status

Research Site

Donetsk, , Ukraine

Site Status

Research Site

Kyiv, , Ukraine

Site Status

Research Site

Lviv, , Ukraine

Site Status

Research Site

Sumy, , Ukraine

Site Status

Research Site

Ternopil, , Ukraine

Site Status

Research Site

Uzhhorod, , Ukraine

Site Status

Research Site

Caracas, , Venezuela

Site Status

Research Site

Caracas, , Venezuela

Site Status

Research Site

Caracas, , Venezuela

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Belgium Brazil Chile Colombia Czechia Hungary India Italy Malta Mexico Poland Russia Slovakia Spain Ukraine Venezuela

References

Explore related publications, articles, or registry entries linked to this study.

Wedam SB, Beaver JA, Amiri-Kordestani L, Bloomquist E, Tang S, Goldberg KB, Sridhara R, Ibrahim A, Kim G, Kluetz P, McKee A, Pazdur R. US Food and Drug Administration Pooled Analysis to Assess the Impact of Bone-Only Metastatic Breast Cancer on Clinical Trial Outcomes and Radiographic Assessments. J Clin Oncol. 2018 Apr 20;36(12):1225-1231. doi: 10.1200/JCO.2017.74.6917. Epub 2018 Mar 9.

Reference Type DERIVED
PMID: 29522361 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2004-002371-16

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

D6997C00002

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Efficacy and Safety of 500mg of Fulvestrant
NCT00585507 ACTIVE_NOT_RECRUITING PHASE2
Second Line Breast Cancer Trial
NCT00635713 COMPLETED PHASE3