Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

NCT ID: NCT00018785

Last Updated: 2009-01-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

1998-10-31

Study Completion Date

2003-09-30

Brief Summary

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Diabetes and end-stage kidney, liver and heart disease are prominent health issues among veteran patients. Successful solid organ transplantation in the absence of chronic immunosuppressive therapy (specific acquired immunological tolerance) is a desirable therapeutic option. This project extends recent observations supporting the use of concommitant donor bone marrow cell infusion as a means of modulating the immune response in kidney transplantation, thereby allowing a substantial decrease or withdrawal of potentially toxic immunosuppressive drugs.

Detailed Description

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Conditions

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Kidney Disease

Study Design

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Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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donor bone marrow infusion

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Living related donor kidney transplant recipients and the living related donors.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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US Department of Veterans Affairs

FED

Sponsor Role lead

Principal Investigators

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Camillo Ricordi, M.D.

Role:

Andreas Tzakis, M.D.

Role:

Violet Esquenazi, Ph.D.

Role:

Keith Zucker, Ph.D.

Role:

Locations

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VAMC Miami

Miami, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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IMMU-035-98S

Identifier Type: -

Identifier Source: org_study_id

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