Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
260 participants
OBSERVATIONAL
1999-05-17
2014-05-30
Brief Summary
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Research has proven that kidneys from living donors are superior to cadaveric donors (kidneys harvested from a deceased individual). Kidneys from living donors are not exposed to extremely low temperature that could increase post-operative problems. They are less likely to experience rejection and there is a decreased likelihood that a patient will have to undergo post-operative dialysis.
The objective of this study is to promote the enrollment of healthy individuals to serve as kidney donors for patients undergoing research kidney transplantation at the NIH. Potential donors will be screened to make sure they are able to survive with a single kidney without significant medical risk. Additional tests will be taken to establish compatibility with the recipient. Compatible donors will be evaluated to determine which kidney is suitable for transplantation. Both the donation and transplantation procedure will be conducted on the same day. Appropriate post-operative care and follow-up will be provided at the Clinical Center.
Detailed Description
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Conditions
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Keywords
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Eligibility Criteria
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Inclusion Criteria
Age greater than or equal to 18 years
ABO compatible with recipient
Normal renal function with a 24hr creatinine clearance greater than 80ml/min/1.73m(2).
Willingness and legal ability to give informed consent
Recipient is enrolled in a NIH protocol for transplantation or has been established as a candidate for receipt of an altruistic or paired donation through the Washington Regional Organ Procurement Agency donor program.
Exclusion Criteria
Pregnancy
History of stroke
Active tuberculosis
History of active malignancies except basal cell carcinoma of the skin.
Major anticipated illness or organ failure incompatible with survival after nephrectomy
Functionally significant coronary artery disease.
Active kidney stones
Proteinuria (greater than 250mg/24hr)
18 Years
ALL
No
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Principal Investigators
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Monique E Cho, M.D.
Role: PRINCIPAL_INVESTIGATOR
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Locations
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National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
Countries
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References
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Cecka JM, Terasaki PI. The UNOS Scientific Renal Transplant Registry. Clin Transpl. 1993:1-18.
Cicciarelli J. Living donor kidney transplants. Clin Transpl. 1988:293-9.
Matas AJ, Gillingham KJ, Sutherland DE. Half-life and risk factors for kidney transplant outcome--importance of death with function. Transplantation. 1993 Apr;55(4):757-61. doi: 10.1097/00007890-199304000-00014.
Other Identifiers
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99-DK-0107
Identifier Type: -
Identifier Source: secondary_id
990107
Identifier Type: -
Identifier Source: org_study_id