Telemedicine to Support Living Kidney Donor Candidates

NCT ID: NCT07206069

Last Updated: 2025-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-10

Study Completion Date

2026-11-30

Brief Summary

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The goal of this feasibility clinical trial is to learn if telemedicine can be used to provide education and evaluation and counseling for people who are considering living kidney donation. The study will also learn how participants improve decision-making about living kidney donation. The main questions to answer are:

* Is telemedicine a practical way to facilitate donor education and evaluation and counseling?
* Does telemedicine shared decision making help improve donor candidate decision and engagement during the donor evaluation process?

Researchers will compare standard care with a telemedicine care coordination approach.

Participants will:

\- Receive either standard care or telemedicine video visits to support shared decision making.

Detailed Description

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Living kidney donation provides a vital treatment option for patients with kidney failure, but many willing individuals face challenges in completing the donor evaluation and committing to donation. Donor education and counseling are essential for informed decision-making, yet these steps are often limited to in-person visits at transplant centers. This can create logistical challenges, delays, and variations in access to the living donor evaluation process. Telemedicine offers an opportunity to deliver a shared decision making approach to donor education and evaluation and counseling remotely, but its feasibility, acceptability, and impact have not been well studied.

This pilot feasibility clinical trial is designed to test whether a telemedicine care coordination can support donor decision-making and engagement during the evaluation process for living kidney donation.

Participants will be randomly assigned to one of two groups:

* Standard Care Group (Control): A recorded video education session and an in-person donor evaluation and counseling with a nephrologist.
* Telemedicine Group (Intervention): Two live telemedicine video sessions-one for education with a transplant provider and one for donor evaluation and counseling with a nephrologist.

The findings from this feasibility trial will provide important information about the practicality and acceptability of telemedicine shared decision-making for living kidney donor candidates. Generated preliminary data will inform larger trials and ultimately guide transplant practice and policy to improve decision-making, efficiency, and access to living kidney donation.

Conditions

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Healthy Living Kidney Donation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Standard Care Group (Control)

Participants in the standard care group will receive a recorded video education session and one in-person donor evaluation and counseling session with a nephrologist.

Group Type ACTIVE_COMPARATOR

Standard Care (in control arm)

Intervention Type BEHAVIORAL

This Standard Care involves a recorded video education and in-person visit.

Telemedicine Group (Intervention)

Participants in the telemedicine group will receive two live telemedicine video sessions: one education session with a transplant provider and one donor evaluation and counseling session with a nephrologist.

Group Type EXPERIMENTAL

Telemedicine Shared Decision-Making

Intervention Type BEHAVIORAL

This intervention involves two live telemedicine video visits.

Interventions

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Standard Care (in control arm)

This Standard Care involves a recorded video education and in-person visit.

Intervention Type BEHAVIORAL

Telemedicine Shared Decision-Making

This intervention involves two live telemedicine video visits.

Intervention Type BEHAVIORAL

Other Intervention Names

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Control Experimental

Eligibility Criteria

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Inclusion Criteria

* 18 years of age or older
* Reside in the State of California
* Registered living kidney donor candidate at UC Irvine Medical Center

Exclusion Criteria

\- Individuals with a contraindication to living kidney donation (for example, heart disease, cancer)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

University of California, Irvine

OTHER

Sponsor Role lead

Responsible Party

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Fawaz Al Ammary

Associate Professor of Medicine, Director of Mixed Methods Research.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Fawaz Al Ammary, MD PhD

Role: PRINCIPAL_INVESTIGATOR

University of California, Irvine

Locations

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University of California Irvine Medical Center

Orange, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Fawaz Al Ammary, MD PhD

Role: CONTACT

657-223-4966

Simeon Adeyemo, MS

Role: CONTACT

714-385-4875

Facility Contacts

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Steven Vasquez

Role: primary

714-456-7431

Stefaney Mendoza-Flores

Role: backup

949-447-9439

References

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Al Ammary F, Adeyemo S, Lentine KL, Muzaale AD. Evolution of Biologically Related Living Kidney Donation in the United States from 1988 to 2022. J Am Soc Nephrol. 2024 Aug 1;35(8):1104-1106. doi: 10.1681/ASN.0000000000000424. Epub 2024 May 29. No abstract available.

Reference Type BACKGROUND
PMID: 38809617 (View on PubMed)

Al Ammary F, Yu Y, Ferzola A, Motter JD, Massie AB, Yu S, Thomas AG, Crews DC, Segev DL, Muzaale AD, Henderson ML. The first increase in live kidney donation in the United States in 15 years. Am J Transplant. 2020 Dec;20(12):3590-3598. doi: 10.1111/ajt.16136. Epub 2020 Jul 17.

Reference Type BACKGROUND
PMID: 32524764 (View on PubMed)

Achkar KA, Abdelnour LM, Abu Jawdeh BG, Tantisattamoa E, Al Ammary F. Evaluation and Long-Term Follow-Up of Living Kidney Donors. Adv Kidney Dis Health. 2024 Sep;31(5):400-407. doi: 10.1053/j.akdh.2024.04.003.

Reference Type BACKGROUND
PMID: 39232610 (View on PubMed)

Al Ammary F, Bowring MG, Massie AB, Yu S, Waldram MM, Garonzik-Wang J, Thomas AG, Holscher CM, Qadi MA, Henderson ML, Wiseman AC, Gralla J, Brennan DC, Segev DL, Muzaale AD. The changing landscape of live kidney donation in the United States from 2005 to 2017. Am J Transplant. 2019 Sep;19(9):2614-2621. doi: 10.1111/ajt.15368. Epub 2019 May 3.

Reference Type BACKGROUND
PMID: 30903733 (View on PubMed)

Al Ammary F, Motter JD, Sung HC, Lentine KL, Sharfuddin A, Kumar V, Yadav A, Doshi MD, Virmani S, Concepcion BP, Grace T, Sidoti CN, Yahya Jan M, Muzaale AD, Wolf J. Telemedicine services for living kidney donation: A US survey of multidisciplinary providers. Am J Transplant. 2022 Aug;22(8):2041-2051. doi: 10.1111/ajt.17093. Epub 2022 May 31.

Reference Type BACKGROUND
PMID: 35575439 (View on PubMed)

Al Ammary F, Muzaale AD, Tantisattamoa E, Hanna RM, Reddy UG, Bunnapradist S, Kalantar-Zadeh K. Changing landscape of living kidney donation and the role of telemedicine. Curr Opin Nephrol Hypertens. 2023 Jan 1;32(1):81-88. doi: 10.1097/MNH.0000000000000848. Epub 2022 Oct 21.

Reference Type BACKGROUND
PMID: 36444666 (View on PubMed)

Kim E, Sung HC, Kaplow K, Bendersky V, Sidoti C, Muzaale AD, Akhtar J, Levan M, Esayed S, Khan A, Mejia C, Al Ammary F. Donor Perceptions and Preferences of Telemedicine and In-Person Visits for Living Kidney Donor Evaluation. Kidney Int Rep. 2024 May 15;9(8):2453-2461. doi: 10.1016/j.ekir.2024.05.009. eCollection 2024 Aug.

Reference Type BACKGROUND
PMID: 39156145 (View on PubMed)

Other Identifiers

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K23DK129820

Identifier Type: NIH

Identifier Source: secondary_id

View Link

UC Irvine IRB#4138

Identifier Type: -

Identifier Source: org_study_id

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