Exposure, Dose, Body Burden and Health Effects of Lead

NCT ID: NCT00013819

Last Updated: 2015-04-14

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 944 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 1997-02-28
• Study Completion Date: 2001-02-28

Brief Summary

This is a study of the effects that lead has on the health of the central nervous system (for example, memory), peripheral nervous system (for example, sensation and strength in the hands and fingers), kidneys, blood pressure, and the blood forming system. A total of 803 lead workers and 135 persons without occupational lead exposure are being studied in South Korea. Lead in the body is being assessed by measurement of blood lead, chelatable lead (an estimate of lead in the tissues), and lead in bone. Subjects are tested three times each over three years. Several genetic factors are also being assessed for the role they play in the health effects of lead. These genes are known to differ among individuals. We are interested to know whether different forms of the same genes can modify the effect lead has on health.

Conditions

Lead Poisoning

Study Design

• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

Lead workers in South Korea in one of 26 specific lead-using facilities.

Population controls in South Korea.

• Minimum Eligible Age: 17 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute of Environmental Health Sciences (NIEHS)

NIH

Sponsor Role: lead

Other Identifiers

7198-CP-001

Identifier Type: -

Identifier Source: org_study_id