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Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks

NCT ID: NCT00010530

Last Updated: 2009-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Study Classification

INTERVENTIONAL

Study Start Date

1999-09-30

Study Completion Date

2006-07-31

Brief Summary

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The purpose of this study is to evaluate the effects of meditation on older African Americans with documented cardiovascular disease (CVD).

Detailed Description

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Cardiovascular disease (CVD) is the leading cause of death and disability in older African Americans, and accounts for 40% of the disproportionate risk for mortality observed in African Americans compared to white Americans. The majority of CVD patients experience acute cardiac events, many sudden and unexpected, despite conventional treatment of their disease and associated traditional risk factors. The pathophysiologic basis of these cardiac events is not fully established, but substantial evidence indicates that psychosocial stress and the sympathetic nervous system have adverse effects on both vasomotor function and long-term autonomic balance. Recent advances in the understanding of the pathophysiology of acute cardiac events-specifically, the roles that arterial vasomotor dysfunction and sympathetic nervous system imbalance play in the pathophysiology of such acute events-provide a platform for a new mechanistic investigation of the interplay of psychosocial and environmental stress and CVD. Preliminary evidence demonstrating elevated peripheral vasoconstriction due to stress-mediated sympathetic nervous system response in African Americans further suggests that these mechanisms are particularly relevant in this group.

Conditions

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Cardiovascular Diseases

Keywords

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CVD

Study Design

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Allocation Method

RANDOMIZED

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Interventions

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Meditation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* African-American (self-identified)
* Local residence
* Able to participate
* Coronary artery disease by MI, CABG, PTCA (\>3 months prior), or angiography
* Consent and referring MD approval
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Center for Complementary and Integrative Health (NCCIH)

NIH

Sponsor Role lead

Principal Investigators

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Robert H. Schneider, MD

Role: PRINCIPAL_INVESTIGATOR

Center for Health and Aging Studies

Locations

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Charles R. Drew University of Medicine and Science

Los Angeles, California, United States

Site Status

Maharishi University of Management Center for Health and Aging Studies

Fairfield, Iowa, United States

Site Status

Countries

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United States

Other Identifiers

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P50AT000082-01

Identifier Type: NIH

Identifier Source: secondary_id

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P50AT000082-02

Identifier Type: NIH

Identifier Source: secondary_id

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P50AT000082-01P1

Identifier Type: NIH

Identifier Source: org_study_id

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NCT00009087

Identifier Type: -

Identifier Source: nct_alias