Effects of Nitrous Oxide: A Dose-Response Analysis - 5

NCT ID: NCT00000253

Last Updated: 2015-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

1994-11-30

Study Completion Date

1996-03-31

Brief Summary

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The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the subjective, psychomotor, and reinforcing effects of nitrous oxide in healthy volunteers. This is a dose-response analysis.

Detailed Description

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Conditions

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Opioid-Related Disorders Substance-Related Disorders

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo + 10% N2O

0% N2O inhaled during psychomotor testing, 10% N2O inhaled during psycho motor testing, then subject's choice of the 2.

Group Type ACTIVE_COMPARATOR

10% N2O

Intervention Type DRUG

Placebo + 20% N2O

Placebo inhaled during psychomotor testing, 20% N2O inhaled during psychomotor testing, then subject's choice of the 2.

Group Type ACTIVE_COMPARATOR

20% N2O

Intervention Type DRUG

Placebo + 30% N2O

Placebo inhaled during psychomotor testing, 30% N2O inhaled during psychomotor testing, then subject's choice of the 2.

Group Type ACTIVE_COMPARATOR

30% N2O

Intervention Type DRUG

Placebo + 40% N2O

Placebo inhaled during psychomotor testing, 40% N2O inhaled during psychomotor testing, then subject's choice of the 2.

Group Type ACTIVE_COMPARATOR

40% N2O

Intervention Type DRUG

Interventions

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10% N2O

Intervention Type DRUG

20% N2O

Intervention Type DRUG

30% N2O

Intervention Type DRUG

40% N2O

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

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Minimum Eligible Age

21 Years

Maximum Eligible Age

37 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

University of Chicago

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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James Zacny, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Chicago

Locations

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University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Behavioral Pharmacology, 1996, 7: 194-199.

Reference Type BACKGROUND

Other Identifiers

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R01DA008391

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01-08391-5

Identifier Type: -

Identifier Source: secondary_id

NIDA-08391-5

Identifier Type: -

Identifier Source: org_study_id

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