Role of Instructions in Nitrous Oxide Effects and Choice - 10

NCT ID: NCT00000258

Last Updated: 2015-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

1996-04-30

Study Completion Date

1997-11-30

Brief Summary

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The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate the role of instructions in nitrous oxide subjective effects and choice.

Detailed Description

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Conditions

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Opioid-Related Disorders Substance-Related Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Informed group

Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.

Group Type ACTIVE_COMPARATOR

Nitrous oxide 10% & placebo

Intervention Type DRUG

Nitrous oxide 20% & placebo

Intervention Type DRUG

Nitrous oxide 30% & placebo

Intervention Type DRUG

Nitrous oxide 40% and placebo

Intervention Type DRUG

Non-informed Group

Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.

Group Type ACTIVE_COMPARATOR

Nitrous oxide 10% & placebo

Intervention Type DRUG

Nitrous oxide 20% & placebo

Intervention Type DRUG

Nitrous oxide 30% & placebo

Intervention Type DRUG

Nitrous oxide 40% and placebo

Intervention Type DRUG

Interventions

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Nitrous oxide 10% & placebo

Intervention Type DRUG

Nitrous oxide 20% & placebo

Intervention Type DRUG

Nitrous oxide 30% & placebo

Intervention Type DRUG

Nitrous oxide 40% and placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

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Minimum Eligible Age

21 Years

Maximum Eligible Age

32 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

University of Chicago

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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James Zacny, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Chicago

Locations

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University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Zacny JP, Cho AM, Toledano AY, Galinkin J, Coalson DW, Klock PA, Klafta JM, Young CJ. Effects of information on the reinforcing, subjective, and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1997 Nov 25;48(2):85-95. doi: 10.1016/s0376-8716(97)00114-2.

Reference Type BACKGROUND
PMID: 9363407 (View on PubMed)

Other Identifiers

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R01DA008391

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01-08391-10

Identifier Type: -

Identifier Source: secondary_id

NIDA-08391-10

Identifier Type: -

Identifier Source: org_study_id

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