Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7

NCT ID: NCT00000255

Last Updated: 2015-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

1995-04-30

Study Completion Date

1996-05-31

Brief Summary

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The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine differential acute tolerance development to effects of nitrous oxide in humans.

Detailed Description

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Conditions

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Opioid-Related Disorders Substance-Related Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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0% Nitrous oxide

Group Type PLACEBO_COMPARATOR

Nitrous oxide

Intervention Type DRUG

10% nitrous oxide

Group Type ACTIVE_COMPARATOR

Nitrous oxide

Intervention Type DRUG

20% nitrous oxide

Group Type ACTIVE_COMPARATOR

Nitrous oxide

Intervention Type DRUG

30% nitrous oxide

Group Type ACTIVE_COMPARATOR

Nitrous oxide

Intervention Type DRUG

40% nitrous oxide

Group Type ACTIVE_COMPARATOR

Nitrous oxide

Intervention Type DRUG

Interventions

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Nitrous oxide

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

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Minimum Eligible Age

21 Years

Maximum Eligible Age

37 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

University of Chicago

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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James Zacny, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Chicago

Locations

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University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Zacny JP, Cho AM, Coalson DW, Rupani G, Young CJ, Klafta JM, Klock PA, Apfelbaum JL. Differential acute tolerance development to effects of nitrous oxide in humans. Neurosci Lett. 1996 May 10;209(2):73-6. doi: 10.1016/0304-3940(96)12626-4.

Reference Type BACKGROUND
PMID: 8761985 (View on PubMed)

Other Identifiers

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R01DA008391

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01-08391-7

Identifier Type: -

Identifier Source: secondary_id

NIDA-08391-7

Identifier Type: -

Identifier Source: org_study_id

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