Effects of Cannabis Administration Routes on Human Performance and Pharmacokinetics
NCT ID: NCT02177513
Last Updated: 2019-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE1
28 participants
INTERVENTIONAL
2014-06-14
2016-04-27
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
\- Marijuana (cannabis) is an illegal drug. Researchers want to study people s reactions, attention, and behavior after they take marijuana in different ways. They want to learn better ways to detect drugs in a person s body They also want to know how long marijuana can be found in blood, urine, saliva, and breath.
Objectives:
\- To learn how people respond to delta-9-tetrahydrocannabinol (THC, a marijuana component) and how their bodies handle it after it is given in different ways.
Eligibility:
\- Adults age 18 50 who use marijuana.
Design:
* Participants are screened under another NIDA protocol.
* This study involves up to 6 visits to NIDA.
* At the first visit, participants will practice the tasks and tests they will do at their dosing sessions. They will learn how to give breath and saliva samples.
* Dosing sessions 1 4 will last 3 5 days each. All participants will be admitted to a research clinic the night before these sessions. Some participants can stay at the clinic and some must go home between sessions.
* At each session, participants will eat a brownie with placebo or marijuana. Then they will smoke a placebo or marijuana cigarette. Some will inhale placebo or marijuana after it is vaporized.
* Throughout the sessions:
* Participants will give urine, saliva, and breath samples. Their blood will be taken with a tube in a vein and finger pricks. Their vital signs will be checked.
* Participants will answer questionnaires and take thinking tests. They will also take tests that assess eye movement, balance, and time estimation.
* Participants may have a 5th dosing session. They will eat a marijuana brownie and have the above tests and samples.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Cannabinoids are most commonly administered via smoking. Oral consumption in medications, teas, oils, or food also is widely utilized. Additionally, cannabis vaporization followed by inhalation for medical and illicit administration is common. Differences in cannabis pharmacodynamics and pharmacokinetics between these three administration routes and in occasional and frequent cannabis smokers are not thoroughly characterized. This study evaluates cannabis pharmacodynamics and pharmacokinetics in occasional and frequent smokers after smoked, vaporized, and oral cannabis administration.
\<TAB\>
Study Population
Up to 80 healthy cannabis smokers, aged 18-50, without a history of adverse reactions to cannabis will be recruited. For dosing sessions 1-4, ten occasional smokers (smoking frequency greater than or equal to 2 times/month but \<3 times/week) and ten frequent smokers (smoking frequency generally greater than or equal to 5times/week) are required. For the optional 5th session, 8-20 participants (regardless of smoking history) are required.
\<TAB\>
Study Design
Occasional and frequent cannabis smokers are recruited to participate. Prior to dosing sessions, there is a training visit for all study procedures. Sessions 1-4 are 3 and 4 days each for occasional and frequent cannabis smokers, respectively, and the study design is double blind, double dummy, randomized, crossover, and placebo-controlled. In each session, participants will consume a placebo or active oral (baked in a brownie) cannabis (6.9% 9-tetrahydrocannabinol \[THC\]) dose followed by either placebo or active smoked or vaporized cannabis. Only one active dose will be administered in each dosing session. Whole blood, oral fluid, urine, dried blood spots, and breath are collected throughout all sessions. Due to the large THC body burden stored in the tissues, we will collect biological specimens for a longer period in frequent cannabis smokers than for occasional cannabis smokers. An optional 5th dosing session will be offered in which participants receive a single oral cannabis dose for pharmacokinetic monitoring. The placebo cannabis plant material has a low THC concentration. As we are expecting that the active brownie dose might result in low THC oral fluid contamination, it is necessary to have an active brownie THC dose that is not followed by placebo vaporizer or smoked cannabis. Occasional smokers may stay or be discharged between sessions, including between the 4th and optional 5th dosing session, but dosing must not exceed self-reported intake frequency. Frequent smokers must be discharged for at least 72 h between dosing sessions 1-4, and must stay on the unit at the end of session 4 for session 5 if they choose to participate. The difference between requirements for occasional and frequent smokers to participate in the optional 5th dose is due to the potential confound of low THC concentrations in frequent smokers that might not permit the detection of low THC concentrations after consumption of a low oral THC dose. Occasional cannabis smokers will reside on the closed research unit for approximately 72 h for dosing sessions 1-4, and for approximately 66 h for dosing session 5. Frequent cannabis smokers will reside on the closed research unit for approximately 90 h for dosing sessions 1-3 (and 4 if not participating in optional session 5). If a frequent smoker chooses to participate in dosing session 5, they will remain on the unit for approximately 162 h for sessions 4 and 5. Participants will complete a battery of subjective, objective, and neurocognitive tests before and after dosing. Subjective effects are assessed with visual analog scales. Objective measurements include physiological measurements, expired carbon monoxide, reddening of the conjunctivae and tests measuring psychomotor skills and cognitive functions.
\<TAB\>
Outcome Parameters
Primary outcome measures include subjective and objective assessments, performance on neurocognitive tasks, and cannabinoid concentrations in whole blood, oral fluid, urine, dried blood spots, and breath. Correlations between cannabinoid concentrations in whole blood, dried blood spots, oral fluid, and breath will be investigated, the Oral Fluid Working Group for the Partnership for Clean Competition oral fluid screening algorithm will be evaluated, and the pharmacokinetic profiles of alternative cannabinoids will be characterized. Secondary investigations include comparing cannabinoid stability in dried blood spots and whole blood, evaluating the World Anti-Doping Agency urine 11-nor-9-carboxy-THC decision limit, characterizing the performance of the Alere DDS2 on-site oral fluid screening device, and evaluating effects of acute cannabis administration on leptin and other appetitive peptides.\<TAB\>
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Keywords
Explore important study keywords that can help with search, categorization, and topic discovery.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
OTHER
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
1
Placebo + Smoked Cannabis
Participants will consume a brownie containing the equivalent of one placebo (0.001% THC) cigarette followed by smoking the equivalent of one active (6.9% THC) cigarette.
2
Placebo + Inhaled Cannabis
Participants will consume a brownie containing the equivalent of one placebo (0.001% THC) cigarette
3
Oral Cannabis + Placebo
Participants will consume a brownie containing the equivalent of one active (6.9% THC) cannabis cigarette followed by either smoking or inhaling (after vaporization) the equivalent of one placebo (0.001% THC) cigarette.
4
Placebo + Placebo
Participants will consume a brownie containing the equivalent of one placebo (0.001% THC) cigarette followed by smoking or inhaling (after vaporization) the equivalent of one placebo (0.001% THC) cigarette.
5
6.9% cannabis oral
Participants will consume a brownie containing the equivalent of one active (6.91% THC) cannabis cigarette.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Placebo + Placebo
Participants will consume a brownie containing the equivalent of one placebo (0.001% THC) cigarette followed by smoking or inhaling (after vaporization) the equivalent of one placebo (0.001% THC) cigarette.
Oral Cannabis + Placebo
Participants will consume a brownie containing the equivalent of one active (6.9% THC) cannabis cigarette followed by either smoking or inhaling (after vaporization) the equivalent of one placebo (0.001% THC) cigarette.
Placebo + Inhaled Cannabis
Participants will consume a brownie containing the equivalent of one placebo (0.001% THC) cigarette
Placebo + Smoked Cannabis
Participants will consume a brownie containing the equivalent of one placebo (0.001% THC) cigarette followed by smoking the equivalent of one active (6.9% THC) cigarette.
6.9% cannabis oral
Participants will consume a brownie containing the equivalent of one active (6.91% THC) cannabis cigarette.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. Cannabis consumption with a minimum frequency of at least twice per month during the three months prior to the study and average frequency of cannabis smoking of less than three times per week (occasional cannabis smoker) in the past 3 months or at least an average of five times per week (frequent cannabis smoker) in the past 3 months;
3. A positive urine cannabinoid screen if in the frequent cannabis smoker group;
4. Peripheral veins suitable for repeated venipuncture and/or placement of an intravenous catheter, as assessed by a physician s assistant, nurse, or physician;
5. Blood pressure (BP) and heart rate (HR) at or below the following values while sitting after five min rest: systolic BP (SBP) 140 mm Hg, diastolic BP (DBP) 90 mm Hg, heart rate (HR) 100 bpm;
6. ECG and three-minute rhythm strip without clinically relevant abnormalities;
7. Women with reproductive potential must use a medically acceptable form of contraception for the duration of the study. Medically acceptable forms of contraception include: oral contraceptive, intrauterine device (IUD), depot hormonal preparation (ring, injection implant), or a barrier method of contraception such as a diaphragm, sponge with spermicide, or a condom. Abstinence is an alternative lifestyle and subjects practicing abstinence may be included in the study.
8. Must be able to safely suspend use of CNS depressant, anticholinergic, and/or sympathomimetic medications before study dosing. Length of medication suspension will be equal to 3 half-lives of the medication in use.
Exclusion Criteria
2. Currently using cannabis for medical purposes under the explicit recommendation of a physician providing medical care;
3. History or presence of any clinically significant illness, as detected by history, physical examination, and/or laboratory tests , that might put the subject at increased risk of adverse events such as history of psychotic disorder, clinically significant mood and/or anxiety disorder, diabetes, liver, renal or cardiovascular disease;
4. Liver enzymes greater than or equal to 2 times upper normal limit and/or clinical signs/symptoms consistent with liver disease including but not limited to nausea, vomiting, jaundice, itching, abdominal pain, and swelling;
5. History of clinically significant adverse events associated with cannabis intoxication such as severe anxiety and panic, paranoia and psychosis, sustained tachycardia, or severe hypotension;
6. Donation of more than 450 mL blood within 8 weeks of study treatment phase;
7. Hemoglobin less than 12.0 g/dL and/or clinical signs/symptoms consistent with anemia including but not limited to fatigue, tachycardia, shortness of breath, and dizziness;
8. If female, pregnant or nursing;
9. Currently interested in or participating in drug abuse treatment, or participated in drug abuse treatment within 90 days preceding study enrollment;
10. History of food allergy or sensitivity to gluten, dairy, egg, soy, and/or chocolate.
11. Any form of color blindness
18 Years
50 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
National Institute on Drug Abuse (NIDA)
NIH
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Marilyn Huestis, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
National Institute on Drug Abuse (NIDA)
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
National Institute on Drug Abuse
Baltimore, Maryland, United States
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Vega WA, Aguilar-Gaxiola S, Andrade L, Bijl R, Borges G, Caraveo-Anduaga JJ, DeWit DJ, Heeringa SG, Kessler RC, Kolody B, Merikangas KR, Molnar BE, Walters EE, Warner LA, Wittchen HU. Prevalence and age of onset for drug use in seven international sites: results from the international consortium of psychiatric epidemiology. Drug Alcohol Depend. 2002 Dec 1;68(3):285-97. doi: 10.1016/s0376-8716(02)00224-7.
Huestis MA. Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol. Handb Exp Pharmacol. 2005;(168):657-90. doi: 10.1007/3-540-26573-2_23.
Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet. 2003;42(4):327-60. doi: 10.2165/00003088-200342040-00003.
Newmeyer MN, Swortwood MJ, Andersson M, Abulseoud OA, Scheidweiler KB, Huestis MA. Cannabis Edibles: Blood and Oral Fluid Cannabinoid Pharmacokinetics and Evaluation of Oral Fluid Screening Devices for Predicting Delta9-Tetrahydrocannabinol in Blood and Oral Fluid following Cannabis Brownie Administration. Clin Chem. 2017 Mar;63(3):647-662. doi: 10.1373/clinchem.2016.265371. Epub 2017 Feb 10.
Newmeyer MN, Swortwood MJ, Taylor ME, Abulseoud OA, Woodward TH, Huestis MA. Evaluation of divided attention psychophysical task performance and effects on pupil sizes following smoked, vaporized and oral cannabis administration. J Appl Toxicol. 2017 Aug;37(8):922-932. doi: 10.1002/jat.3440. Epub 2017 Jan 31.
Newmeyer MN, Swortwood MJ, Barnes AJ, Abulseoud OA, Scheidweiler KB, Huestis MA. Free and Glucuronide Whole Blood Cannabinoids' Pharmacokinetics after Controlled Smoked, Vaporized, and Oral Cannabis Administration in Frequent and Occasional Cannabis Users: Identification of Recent Cannabis Intake. Clin Chem. 2016 Dec;62(12):1579-1592. doi: 10.1373/clinchem.2016.263475. Epub 2016 Oct 10.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
14-DA-N135
Identifier Type: -
Identifier Source: secondary_id
999914135
Identifier Type: -
Identifier Source: org_study_id