Clinical Trials

Showing trials with last updates posted in 2025.

NCT05437562 | NOT_YET_RECRUITING | NA
120 Participants

Randomized Clinical Trial for Ewing Amputation in the VA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2026-01-15
Completion: 2030-01-15
Conditions
Peripheral Arterial Disease
Interventions
PROCEDURE
No Results Yet
NCT05427448 | COMPLETED | NA
342 Participants

Validation of Blood Biomarkers for Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-24
Completion: 2025-05-20
Conditions
Alzheimer Disease Mild Cognitive Impairment Dementia Tauopathies
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT05410548 | COMPLETED | NA
70 Participants

Comorbidity Screening and Referral by Prosthetists

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-09
Completion: 2023-01-30
Conditions
Limb Ischemia Low Back Pain Depression Neuropathy;Peripheral Amputation
Interventions
OTHER
No Results Yet
NCT05389449 | ACTIVE_NOT_RECRUITING | PHASE3
80 Participants

A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-28
Completion: 2026-07-31
Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG
No Results Yet
NCT05389293 | RECRUITING | PHASE2
152 Participants

A Study of Mosunetuzumab Alone or With Zanubrutinib in People With Follicular Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-27
Completion: 2026-12-31
Conditions
Follicular Lymphoma Lymphoma
Interventions
DRUG
No Results Yet
NCT05379829 | COMPLETED | PHASE1
24 Participants

A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-30
Completion: 2024-06-12
Conditions
Chronic Kidney Disease and Systemic Inflammation
Interventions
DRUG
No Results Yet
NCT05379023 | COMPLETED | NA
116 Participants

VIdeo Telehealth in ALzheimer's: NeuroPsychology (VITAL-NP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-27
Completion: 2024-05-16
Conditions
Suspected Typical Alzheimer's Disease (AD) Suspected Atypical Alzheimer's Disease (AD)
Interventions
BEHAVIORAL
NCT05372679 | ACTIVE_NOT_RECRUITING | NA
25 Participants

REDUCED 1 - Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study /

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-11
Completion: 2025-12-31
Conditions
Uncontrolled Stage 2 Hypertension
Interventions
DEVICE
No Results Yet
NCT05365035 | RECRUITING | PHASE2
60 Participants

A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax, Alternating With Azacitidine and Venetoclax, in Patients With Higher-risk Myeloproliferative Chronic Myelomonocytic Leukemia or Higher-risk Myelodysplastic Syndromes With Excess Blasts

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-09-23
Completion: 2027-12-31
Conditions
Myelodysplastic Syndromes Myeloproliferative Chronic Myelomonocytic Leukemia
Interventions
DRUG
No Results Yet
NCT05364957 | RECRUITING | NA
84 Participants

Intragastric Balloon in Obese Patients With Uncontrolled Asthma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-12
Completion: 2029-07-31
Conditions
Obesity Asthma
Interventions
DEVICE PROCEDURE
No Results Yet
NCT05363774 | COMPLETED | PHASE1
161 Participants

A Research Study of a New Medicine NNC0519-0130 in Healthy People, People With High Body Weight and People With Type 2 Diabetes.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-20
Completion: 2024-04-02
Conditions
Healthy Volunteers (Diabetes Mellitus, Type 2)
Interventions
DRUG
No Results Yet
NCT05349422 | COMPLETED | NA
1726 Participants

Addressing Antihypertensive Medication Adherence Through EHR-enabled Teamlets in Primary Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-06
Completion: 2024-11-11
Conditions
Blood Pressure Medication Adherence
Interventions
BEHAVIORAL
No Results Yet
NCT05329766 | ACTIVE_NOT_RECRUITING | PHASE2
332 Participants

A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-10
Completion: 2027-01-31
Conditions
Gastrointestinal Tract Malignancies
Interventions
DRUG
No Results Yet
NCT05312047 | COMPLETED
609 Participants

Continence After Vaginal Prolapse Surgery

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-04
Completion: 2025-09-19
Conditions
Pelvic Organ Prolapse Urinary Incontinence
Interventions
PROCEDURE
No Results Yet
NCT05307289 | RECRUITING | NA
20 Participants

Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-25
Completion: 2028-05-25
Conditions
Melanoma (Skin)
Interventions
OTHER
No Results Yet
NCT05304065 | RECRUITING | PHASE2
1600 Participants

Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-17
Completion: 2026-12-31
Conditions
Suicide Suicidal Self-Harm
Interventions
BEHAVIORAL
No Results Yet
NCT05289466 | TERMINATED | NA
5 Participants

Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-12-16
Completion: 2024-10-23
Conditions
IORT-Intra-Operative Radiation Therapy
Interventions
RADIATION PROCEDURE
No Results Yet
NCT05271552 | COMPLETED | PHASE3
151 Participants

Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-27
Completion: 2023-04-21
Conditions
Agitation Dementia
Interventions
DRUG
NCT05269004 | ACTIVE_NOT_RECRUITING | PHASE3
1300 Participants

A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-03
Completion: 2029-12-31
Conditions
Multiple Sclerosis
Interventions
DRUG
No Results Yet
NCT05260957 | RECRUITING | PHASE2
22 Participants

CAR-T Cell Therapy, Mosunetuzumab and Polatuzumab for Treatment of Refractory/Relapsed Aggressive Non-Hodgkin's Lymphoma (NHL).

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-12-14
Completion: 2026-12-31
Conditions
Refractory Non-Hodgkin Lymphoma Relapsed Non Hodgkin Lymphoma Aggressive Non-Hodgkin Lymphoma
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05238922 | RECRUITING | PHASE1
604 Participants

Study of INCB123667 in Subjects With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-07-05
Completion: 2027-07-27
Conditions
Solid Tumors
Interventions
DRUG
No Results Yet
NCT05172011 | ACTIVE_NOT_RECRUITING
15028 Participants

Understanding the Long-term Impact of COVID on Children and Families

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-03-01
Completion: 2027-04-01
Conditions
SARS-CoV-2 Infection
No Results Yet
NCT05147662 | COMPLETED | PHASE3
36 Participants
NCT05132296 | ACTIVE_NOT_RECRUITING | NA
30 Participants

Mobile-Health Delivery of Lifestyle Interventions for Women With Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-05-21
Completion: 2026-06-15
Conditions
Breast Carcinoma
Interventions
BEHAVIORAL OTHER DEVICE
No Results Yet
NCT05129020 | ACTIVE_NOT_RECRUITING | NA
52 Participants

Neurostimulation to Improve NOWS Outcomes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-07-27
Completion: 2025-01-31
Conditions
Neonatal Opioid Withdrawal Syndrome Neonatal Abstinence Syndrome
Interventions
DEVICE
No Results Yet
NCT05123703 | ACTIVE_NOT_RECRUITING | PHASE3
188 Participants

A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis (RRMS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-19
Completion: 2025-06-09
Conditions
Relapsing-Remitting Multiple Sclerosis
Interventions
DRUG OTHER
No Results Yet
NCT05117957 | COMPLETED | PHASE2
50 Participants

Efficacy and Safety of Sorafenib in Previously Treated Advanced Hepatocellular Carcinoma: SOPT Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-03-08
Completion: 2025-06-30
Conditions
Advanced Hepatocellular Carcinoma
Interventions
DRUG
No Results Yet
NCT05116514 | RECRUITING | NA
256 Participants

Evaluation of the Impact of Case Manager Intervention on the 3-year Psychotic Episode Recurrence Rate in Patients Aged 16 to 30 Years With a First Psychotic Episode.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-09-27
Completion: 2028-09-30
Conditions
Psychotic Episode
Interventions
OTHER
No Results Yet
NCT05109975 | ACTIVE_NOT_RECRUITING | PHASE1
155 Participants

A Study to Evaluate Safety and Preliminary Anti-tumor Activity of Debio 0123 as Monotherapy in Adult Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-11-05
Completion: 2026-01-31
Conditions
Advanced Solid Tumors
Interventions
DRUG
No Results Yet
NCT05108298 | RECRUITING | NA
400 Participants

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-11-10
Completion: 2027-05-01
Conditions
Breast Cancer, NOS CNS Primary Tumor, NOS Cervical Cancer, NOS Colorectal Cancer, NOS Leukemia, NOS Lymphoma, NOS Miscellaneous Neoplasm, NOS Non-Rhabdomyosarcoma Soft Tissue Sarcoma, NOS Testicular Nonseminomatous Germ Cell Tumor, NOS Thyroid Cancer, NOS Melanoma Bone Cancer, NOS
Interventions
OTHER
No Results Yet
NCT05080569 | RECRUITING | PHASE4
1008 Participants

Luteal Phase Support in IUI MOH Treatment Luteal Phase Support in IUI MOH Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-03-01
Completion: 2025-12-31
Conditions
Pregnancy Related Fertility Issues Luteal Phase Defect Infertility Unexplained
Interventions
DRUG
No Results Yet
NCT05069545 | COMPLETED
411 Participants

A Research Study Looking at How the Use of NovoPen® 6 for Treatment With Tresiba® & Fiasp® Affects the Blood Sugar Level in Patients With Type 1 Diabetes as Part of Local Clinical Practice

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2021-10-11
Completion: 2024-09-10
Conditions
Diabetes Mellitus, Type 1
Interventions
DRUG
No Results Yet
NCT05064826 | ACTIVE_NOT_RECRUITING | NA
170 Participants

ED Observation for Opioid Use Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-21
Completion: 2025-06-01
Conditions
Opioid Use Disorder
Interventions
OTHER
No Results Yet
NCT05058313 | COMPLETED | NA
25 Participants

Evaluation of the Safety and Performance of the MILTA GYNECO Vaginal Probe in Postmenopausal Women With Vaginal Atrophy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-03-29
Completion: 2023-06-13
Conditions
Menopause Urinary Incontinence Atrophic Vaginitis
Interventions
DEVICE
No Results Yet
NCT05048212 | RECRUITING | PHASE2
20 Participants

A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-09-20
Completion: 2027-01-31
Conditions
Brain Metastases Renal Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT05039515 | ACTIVE_NOT_RECRUITING | PHASE2
113 Participants

A Study to Assess the Effectiveness and Safety of 2 Dosage Regimens of Oral Fidrisertib (IPN60130) for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP).

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-12-01
Completion: 2029-03-30
Conditions
Fibrodysplasia Ossificans Progressiva
Interventions
DRUG
No Results Yet
NCT05030493 | ACTIVE_NOT_RECRUITING
787 Participants

An Additional Analysis of Data From the PARADIGM Exploratory Study (NCT02394834) in Patients With Advanced/Recurrent Colorectal Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2021-08-31
Completion: 2027-07-31
Conditions
Colorectal Cancer
Interventions
DRUG
No Results Yet
NCT05030428 | ACTIVE_NOT_RECRUITING | PHASE3
17004 Participants

Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-11-23
Completion: 2027-10-13
Conditions
Atherosclerotic Cardiovascular Disease
Interventions
DRUG
No Results Yet
NCT05021562 | ACTIVE_NOT_RECRUITING
354 Participants

A Study of Niraparib in Patients With Ovarian Cancer in Clinical Practice

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2021-09-13
Completion: 2026-03-31
Conditions
Ovarian Cancer
Interventions
DRUG
No Results Yet
NCT05011903 | NOT_YET_RECRUITING | NA
600 Participants

Integrative Alcohol and Risky Sex Feedback for College Students

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2026-02-01
Completion: 2027-01-31
Conditions
Alcohol Drinking in College Sexual Behavior
Interventions
BEHAVIORAL
No Results Yet
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