Clinical Trials

Showing trials with last updates posted in 2025.

NCT05472883 | RECRUITING | NA
50 Participants

Identification of Human Biomarkers Predictive of Diabetes Remission in Type 2 Diabetes Patient (BARIAKINES)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-02-27
Completion: 2025-12-31
Conditions
Type 2 Diabetes
Interventions
PROCEDURE
No Results Yet
NCT05470816 | ACTIVE_NOT_RECRUITING | PHASE3
826 Participants

Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-01
Completion: 2026-08-13
Conditions
Surgical Site Infection Dementia Cognition
Interventions
DRUG
No Results Yet
NCT05468333 | COMPLETED | NA
184 Participants

"Natural" and "Organic" Cigarette Descriptors: Association With Expectancies, Subjective Effects, Topography, and Biomarkers of Exposure Among Daily Smokers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-01-20
Completion: 2024-08-31
Conditions
Smoking Behaviors
Interventions
OTHER
No Results Yet
NCT05463224 | ACTIVE_NOT_RECRUITING | PHASE2
150 Participants

Lazertinib for NSCLC Harboring Activating EGFR Mutations in TKI naïve Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-01-02
Completion: 2026-03-31
Conditions
NSCLC
Interventions
DRUG
No Results Yet
NCT05456295 | COMPLETED | NA
35 Participants

Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-17
Completion: 2025-09-29
Conditions
Healthy Lower Limb Injury Post-Traumatic Osteoarthritis
Interventions
DEVICE
No Results Yet
NCT05449301 | COMPLETED | NA
63 Participants

Effects of Unilateral Step Training on Gait and Balance in Stroke Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-01-01
Completion: 2024-06-30
Conditions
Stroke
Interventions
OTHER
No Results Yet
NCT05442216 | RECRUITING | PHASE2
53 Participants

Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-05-01
Completion: 2027-08-31
Conditions
Acute Myeloid Leukemia
Interventions
DRUG
No Results Yet
NCT05437562 | NOT_YET_RECRUITING | NA
120 Participants

Randomized Clinical Trial for Ewing Amputation in the VA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2026-01-15
Completion: 2030-01-15
Conditions
Peripheral Arterial Disease
Interventions
PROCEDURE
No Results Yet
NCT05432791 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
190 Participants

Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-03-30
Completion: 2030-03-09
Conditions
Locally Advanced Uterine Corpus Leiomyosarcoma Metastatic Uterine Corpus Leiomyosarcoma Stage III Uterine Corpus Leiomyosarcoma AJCC v8 Stage IV Uterine Corpus Leiomyosarcoma AJCC v8 Unresectable Uterine Corpus Leiomyosarcoma
Interventions
PROCEDURE DRUG
No Results Yet
NCT05427448 | COMPLETED | NA
342 Participants

Validation of Blood Biomarkers for Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-24
Completion: 2025-05-20
Conditions
Alzheimer Disease Mild Cognitive Impairment Dementia Tauopathies
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT05410548 | COMPLETED | NA
70 Participants

Comorbidity Screening and Referral by Prosthetists

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-09
Completion: 2023-01-30
Conditions
Limb Ischemia Low Back Pain Depression Neuropathy;Peripheral Amputation
Interventions
OTHER
No Results Yet
NCT05389449 | ACTIVE_NOT_RECRUITING | PHASE3
80 Participants

A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-28
Completion: 2026-07-31
Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG
No Results Yet
NCT05389293 | RECRUITING | PHASE2
152 Participants

A Study of Mosunetuzumab Alone or With Zanubrutinib in People With Follicular Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-27
Completion: 2026-12-31
Conditions
Follicular Lymphoma Lymphoma
Interventions
DRUG
No Results Yet
NCT05379829 | COMPLETED | PHASE1
24 Participants

A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-30
Completion: 2024-06-12
Conditions
Chronic Kidney Disease and Systemic Inflammation
Interventions
DRUG
No Results Yet
NCT05379023 | COMPLETED | NA
116 Participants

VIdeo Telehealth in ALzheimer's: NeuroPsychology (VITAL-NP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-27
Completion: 2024-05-16
Conditions
Suspected Typical Alzheimer's Disease (AD) Suspected Atypical Alzheimer's Disease (AD)
Interventions
BEHAVIORAL
NCT05372679 | ACTIVE_NOT_RECRUITING | NA
25 Participants

REDUCED 1 - Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study /

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-11
Completion: 2025-12-31
Conditions
Uncontrolled Stage 2 Hypertension
Interventions
DEVICE
No Results Yet
NCT05365035 | RECRUITING | PHASE2
60 Participants

A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax, Alternating With Azacitidine and Venetoclax, in Patients With Higher-risk Myeloproliferative Chronic Myelomonocytic Leukemia or Higher-risk Myelodysplastic Syndromes With Excess Blasts

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-09-23
Completion: 2027-12-31
Conditions
Myelodysplastic Syndromes Myeloproliferative Chronic Myelomonocytic Leukemia
Interventions
DRUG
No Results Yet
NCT05364957 | RECRUITING | NA
84 Participants

Intragastric Balloon in Obese Patients With Uncontrolled Asthma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-12
Completion: 2029-07-31
Conditions
Obesity Asthma
Interventions
DEVICE PROCEDURE
No Results Yet
NCT05363774 | COMPLETED | PHASE1
161 Participants

A Research Study of a New Medicine NNC0519-0130 in Healthy People, People With High Body Weight and People With Type 2 Diabetes.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-20
Completion: 2024-04-02
Conditions
Healthy Volunteers (Diabetes Mellitus, Type 2)
Interventions
DRUG
No Results Yet
NCT05349422 | COMPLETED | NA
1726 Participants

Addressing Antihypertensive Medication Adherence Through EHR-enabled Teamlets in Primary Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-06
Completion: 2024-11-11
Conditions
Blood Pressure Medication Adherence
Interventions
BEHAVIORAL
No Results Yet
NCT05329766 | ACTIVE_NOT_RECRUITING | PHASE2
332 Participants

A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-10
Completion: 2027-01-31
Conditions
Gastrointestinal Tract Malignancies
Interventions
DRUG
No Results Yet
NCT05312047 | COMPLETED
609 Participants

Continence After Vaginal Prolapse Surgery

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-04
Completion: 2025-09-19
Conditions
Pelvic Organ Prolapse Urinary Incontinence
Interventions
PROCEDURE
No Results Yet
NCT05307289 | RECRUITING | NA
20 Participants

Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-25
Completion: 2028-05-25
Conditions
Melanoma (Skin)
Interventions
OTHER
No Results Yet
NCT05304065 | RECRUITING | PHASE2
1600 Participants

Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-17
Completion: 2026-12-31
Conditions
Suicide Suicidal Self-Harm
Interventions
BEHAVIORAL
No Results Yet
NCT05289466 | TERMINATED | NA
5 Participants

Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-12-16
Completion: 2024-10-23
Conditions
IORT-Intra-Operative Radiation Therapy
Interventions
RADIATION PROCEDURE
No Results Yet
NCT05271552 | COMPLETED | PHASE3
151 Participants

Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-27
Completion: 2023-04-21
Conditions
Agitation Dementia
Interventions
DRUG
NCT05269004 | ACTIVE_NOT_RECRUITING | PHASE3
1300 Participants

A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-03
Completion: 2029-12-31
Conditions
Multiple Sclerosis
Interventions
DRUG
No Results Yet
NCT05260957 | RECRUITING | PHASE2
22 Participants

CAR-T Cell Therapy, Mosunetuzumab and Polatuzumab for Treatment of Refractory/Relapsed Aggressive Non-Hodgkin's Lymphoma (NHL).

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-12-14
Completion: 2026-12-31
Conditions
Refractory Non-Hodgkin Lymphoma Relapsed Non Hodgkin Lymphoma Aggressive Non-Hodgkin Lymphoma
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05238922 | RECRUITING | PHASE1
604 Participants

Study of INCB123667 in Subjects With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-07-05
Completion: 2027-07-27
Conditions
Solid Tumors
Interventions
DRUG
No Results Yet
NCT05172011 | ACTIVE_NOT_RECRUITING
15028 Participants

Understanding the Long-term Impact of COVID on Children and Families

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-03-01
Completion: 2027-04-01
Conditions
SARS-CoV-2 Infection
No Results Yet
NCT05147662 | COMPLETED | PHASE3
36 Participants
NCT05132296 | ACTIVE_NOT_RECRUITING | NA
30 Participants

Mobile-Health Delivery of Lifestyle Interventions for Women With Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-05-21
Completion: 2026-06-15
Conditions
Breast Carcinoma
Interventions
BEHAVIORAL OTHER DEVICE
No Results Yet
NCT05129020 | ACTIVE_NOT_RECRUITING | NA
52 Participants

Neurostimulation to Improve NOWS Outcomes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-07-27
Completion: 2025-01-31
Conditions
Neonatal Opioid Withdrawal Syndrome Neonatal Abstinence Syndrome
Interventions
DEVICE
No Results Yet
NCT05123703 | ACTIVE_NOT_RECRUITING | PHASE3
188 Participants

A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis (RRMS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-19
Completion: 2025-06-09
Conditions
Relapsing-Remitting Multiple Sclerosis
Interventions
DRUG OTHER
No Results Yet
NCT05117957 | COMPLETED | PHASE2
50 Participants

Efficacy and Safety of Sorafenib in Previously Treated Advanced Hepatocellular Carcinoma: SOPT Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-03-08
Completion: 2025-06-30
Conditions
Advanced Hepatocellular Carcinoma
Interventions
DRUG
No Results Yet
NCT05116514 | RECRUITING | NA
256 Participants

Evaluation of the Impact of Case Manager Intervention on the 3-year Psychotic Episode Recurrence Rate in Patients Aged 16 to 30 Years With a First Psychotic Episode.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-09-27
Completion: 2028-09-30
Conditions
Psychotic Episode
Interventions
OTHER
No Results Yet
NCT05109975 | ACTIVE_NOT_RECRUITING | PHASE1
155 Participants

A Study to Evaluate Safety and Preliminary Anti-tumor Activity of Debio 0123 as Monotherapy in Adult Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-11-05
Completion: 2026-01-31
Conditions
Advanced Solid Tumors
Interventions
DRUG
No Results Yet
NCT05108298 | RECRUITING | NA
400 Participants

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-11-10
Completion: 2027-05-01
Conditions
Breast Cancer, NOS CNS Primary Tumor, NOS Cervical Cancer, NOS Colorectal Cancer, NOS Leukemia, NOS Lymphoma, NOS Miscellaneous Neoplasm, NOS Non-Rhabdomyosarcoma Soft Tissue Sarcoma, NOS Testicular Nonseminomatous Germ Cell Tumor, NOS Thyroid Cancer, NOS Melanoma Bone Cancer, NOS
Interventions
OTHER
No Results Yet
NCT05080569 | RECRUITING | PHASE4
1008 Participants

Luteal Phase Support in IUI MOH Treatment Luteal Phase Support in IUI MOH Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-03-01
Completion: 2025-12-31
Conditions
Pregnancy Related Fertility Issues Luteal Phase Defect Infertility Unexplained
Interventions
DRUG
No Results Yet
NCT05069545 | COMPLETED
411 Participants

A Research Study Looking at How the Use of NovoPen® 6 for Treatment With Tresiba® & Fiasp® Affects the Blood Sugar Level in Patients With Type 1 Diabetes as Part of Local Clinical Practice

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2021-10-11
Completion: 2024-09-10
Conditions
Diabetes Mellitus, Type 1
Interventions
DRUG
No Results Yet
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