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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04747431 | RECRUITING | PHASE1/PHASE2
30 Participants

A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-09-14
Completion: 2028-08-31
Conditions
Frontotemporal Dementia FTD FTD-GRN Dementia Frontotemporal C9orf72
Interventions
DRUG
No Results Yet
NCT04745221 | RECRUITING | NA
100 Participants

Efficacy and Safety of Auto-FMT in Preventing aGVHD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-03-01
Completion: 2026-03-01
Conditions
Graft Versus Host Disease, Acute
Interventions
OTHER
No Results Yet
NCT04737720 | COMPLETED
1 Participants

Intravenous ACP-501 for Familial LCAT Deficiency (rhLCAT)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2013-01-24
Completion: 2013-12-12
Conditions
Familial LCAT Deficiency
Interventions
DRUG
No Results Yet
NCT04737460 | ACTIVE_NOT_RECRUITING | PHASE1
4 Participants

Study for the Treatment for CLN7 Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-05-04
Completion: 2028-02-01
Conditions
CLN7
Interventions
GENETIC
No Results Yet
NCT04708470 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
55 Participants

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-10-05
Completion: 2026-11-30
Conditions
Oropharyngeal Cancer Neck Cancer Human Papillomavirus HPV Anal Cancer Cervical Cancer Penile Cancer Vulvar Cancer Vaginal Cancer Colon Cancer
Interventions
DRUG
No Results Yet
NCT04685200 | RECRUITING
143 Participants

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2023-03-31
Completion: 2026-10-31
Conditions
Primary Sclerosing Cholangitis
No Results Yet
NCT04660487 | RECRUITING
100 Participants

Relationship Between "FODMAPs" and "GVHD"

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-01
Completion: 2026-12-01
Conditions
Graft Versus Host Disease
No Results Yet
NCT04621435 | RECRUITING | PHASE1
191 Participants

Imaging of Solid Tumors Using FAP-2286

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-14
Completion: 2026-12-31
Conditions
Solid Tumors, Adult Metastatic Cancer
Interventions
DRUG PROCEDURE
No Results Yet
NCT04609072 | RECRUITING
200000 Participants

Connect for Cancer Prevention Study (Connect)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2021-07-26
Completion: 2070-12-31
Conditions
Cancer General Research Use
No Results Yet
NCT04601857 | TERMINATED | PHASE2
43 Participants

Futibatinib and Pembrolizumab Combination in the Treatment of Advanced or Metastatic Urothelial Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-01-07
Completion: 2024-03-08
Conditions
Advanced and Metastatic Urothelial Cancer
Interventions
DRUG
Results Available
NCT04560673 | RECRUITING | PHASE2
380 Participants

Duloxetine and Neurofeedback Training for the Treatment of Chemotherapy Induced Peripheral Neuropathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-07-10
Completion: 2026-12-31
Conditions
Chemotherapy-Induced Peripheral Neuropathy Hematopoietic and Lymphoid Cell Neoplasm Malignant Solid Neoplasm
Interventions
DRUG BEHAVIORAL OTHER
No Results Yet
NCT04557969 | RECRUITING
400 Participants

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-18
Completion: 2040-12-30
Conditions
Gastric Cancer Gastric Neoplasm Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Neoplasm Gastrointestinal Stromal Tumor (GIST)
No Results Yet
NCT04542733 | RECRUITING | NA
50 Participants

The Efficacy of Everolimus With Reduced-dose Tacrolimus Versus Reduced-dose Tacrolimus and Leflunomide in Treatment of BK Virus Infection in Kidney Transplantation Recipient

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-02-10
Completion: 2025-12-24
Conditions
Kidney Transplant Infection BK Virus Infection
Interventions
DRUG
No Results Yet
NCT04469855 | COMPLETED
3217 Participants

Post-Marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Ozempic®

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-07-27
Completion: 2025-05-12
Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG
No Results Yet
NCT04453917 | COMPLETED | NA
22 Participants

Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-02-23
Completion: 2024-07-12
Conditions
Progressive Multifocal Leukoencephalopathy
Interventions
BIOLOGICAL DIAGNOSTIC_TEST
No Results Yet
NCT04451135 | ACTIVE_NOT_RECRUITING | NA
31 Participants

CET- REM (Correlating ECT Response to EEG Markers)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-10-09
Completion: 2026-06-30
Conditions
ECT Treatment Resistant Depression
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04443660 | COMPLETED
97 Participants

Autophagy/Apoptosis Balance During Pregnancy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-30
Completion: 2024-09-30
Conditions
Pregnancy Related
Interventions
OTHER
No Results Yet
NCT04417660 | RECRUITING | PHASE2
44 Participants

Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-26
Completion: 2026-03-31
Conditions
Thymic Epithelial Tumor Recurrent Thymoma Thymic Cancer
Interventions
DRUG
No Results Yet
NCT04411147 | ACTIVE_NOT_RECRUITING
583 Participants

A Longitudinal Study of COVID-19 Sequelae and Immunity

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-17
Completion: 2027-12-31
Conditions
COVID-19
No Results Yet
NCT04364217 | WITHDRAWN | NA
0 Participants

Pain and Itch Reduction in Burn Scars Treated With Fractional CO2 Laser

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-25
Completion: 2025-03-31
Conditions
Hypertrophic Scar Burn Scar
Interventions
DEVICE
No Results Yet
NCT04356755 | RECRUITING | PHASE2
32 Participants

Subcutaneous Injections of ASC to Heal Digital Ulcers in Patients With Scleroderma.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-09-22
Completion: 2027-03-31
Conditions
Systemic Sclerosis
Interventions
DRUG
No Results Yet
NCT04353375 | RECRUITING | PHASE2/PHASE3
235 Participants

HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-09-03
Completion: 2028-06-30
Conditions
Advanced Intrahepatic Cholangiocarcinoma Solid Tumor, Adult
Interventions
DRUG
No Results Yet
NCT04316546 | RECRUITING | PHASE2
45 Participants

MK-7075 (Miransertib) in Proteus Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-20
Completion: 2026-07-01
Conditions
Proteus Syndrome
Interventions
DRUG
No Results Yet
NCT04311606 | COMPLETED | PHASE2
11 Participants

Anti-VEGF Therapy for Acute Thyroid Eye Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-11-02
Completion: 2024-12-17
Conditions
Thyroid Eye Disease
Interventions
DRUG
No Results Yet
NCT04307134 | COMPLETED
108 Participants

Besponsa Post Marketing Surveillance Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-07-09
Completion: 2024-12-24
Conditions
Hematologic Malignancy
Interventions
DRUG
Results Available
NCT04297683 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
1500 Participants

HEALEY ALS Platform Trial - Master Protocol

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-14
Completion: 2027-11-30
Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG
No Results Yet
NCT04269902 | RECRUITING | PHASE3
247 Participants

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-03-02
Completion: 2028-10-01
Conditions
Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma
Interventions
PROCEDURE BIOLOGICAL OTHER DRUG
No Results Yet
NCT04227509 | COMPLETED | PHASE2
53 Participants

Consolidation Pembrolizumab After Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-04
Completion: 2024-08-21
Conditions
Nasopharyngeal Carcinoma
Interventions
DRUG
No Results Yet
NCT04224337 | COMPLETED | PHASE2
16 Participants

Phase II Study of Durvalumab ,Doxorubicin, and Ifosfamide in Pulmonary Sarcomatoid Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-11
Completion: 2023-08-14
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
No Results Yet
NCT04203160 | TERMINATED | PHASE1/PHASE2
75 Participants

Gemcitabine and Cisplatin With or Without CPI-613 as First Line Therapy for Patients With Advanced Unresectable Biliary Tract Cancer (BilT-04)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-23
Completion: 2024-04-16
Conditions
Biliary Tract Cancer
Interventions
DRUG
Results Available
NCT04192435 | COMPLETED | PHASE4
3300 Participants

Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-18
Completion: 2025-09-13
Conditions
Infection Wound Gastrointestinal Complication Anesthesia Bleeding Healthcare Associated Infection
Interventions
DRUG
No Results Yet
NCT04172922 | TERMINATED | PHASE1
5 Participants

Topical Rapamycin/Sirolimus for Complicated Vascular Anomalies and Other Susceptible Lesions

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-04-01
Completion: 2024-02-15
Conditions
Vascular Anomaly
Interventions
DRUG
No Results Yet
NCT04141449 | ACTIVE_NOT_RECRUITING | PHASE2
874 Participants

A Multilevel Intervention to Improve Timely Cancer Detection and Treatment Initiation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-11-18
Completion: 2026-09-30
Conditions
Neoplasms Hiv Cervical Cancer Breast Cancer HNSCC Vulvar Cancer Anal Cancer Cancer Suspect
Interventions
OTHER
No Results Yet
NCT04124198 | ACTIVE_NOT_RECRUITING | NA
138 Participants

Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-03-01
Completion: 2025-12-16
Conditions
Oropharynx Cancer Oropharynx Squamous Cell Carcinoma Carcinoma, Squamous Cell Carcinoma Oropharyngeal Neoplasms Neoplasms, Squamous Cell Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Pharyngeal Neoplasms Malignant and Unspecified Otorhinolaryngologic Neoplasms Head and Neck Neoplasms Neoplasms by Site Otorhinolaryngologic Diseases Pharyngeal Diseases Papillomavirus Infections Virus Diseases DNA Virus Infections Tumor Virus Infections Quality of Life
Interventions
RADIATION DRUG PROCEDURE
No Results Yet
NCT04116905 | COMPLETED | NA
68 Participants

Intensive Lifestyle Intervention for Remission of Metabolic Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-10-01
Completion: 2022-08-31
Conditions
Metabolic Syndrome
Interventions
BEHAVIORAL
No Results Yet
NCT04115319 | COMPLETED | PHASE3
305 Participants

A Study of the Long-term Safety and Tolerability of an Investigational Drug in People With Schizophrenia.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-11-21
Completion: 2022-12-30
Conditions
Schizophrenia
Interventions
DRUG
Results Available
NCT04091009 | WITHDRAWN | PHASE4
0 Participants

Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post-Operative Opioid Use Disorder Symptoms

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-10-31
Completion: 2025-12-31
Conditions
Opioid-use Disorder Opioid Use Disorder, Mild
Interventions
DRUG
No Results Yet
NCT04064086 | ACTIVE_NOT_RECRUITING | NA
656 Participants

Trial to Evaluate and Assess the Effect of Comprehensive Pre-ESKD Education on Home Dialysis Use in Veterans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-03-25
Completion: 2025-09-30
Conditions
Chronic Kidney Disease End Stage Renal Disease Hemodialysis Peritoneal Dialysis
Interventions
OTHER
No Results Yet
NCT04034264 | RECRUITING
6500 Participants

Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2019-07-23
Completion: 2026-07-01
Conditions
Vector-Borne Diseases Emerging Pathogens
No Results Yet
NCT04023552 | ACTIVE_NOT_RECRUITING | PHASE3
8323 Participants

Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-12-12
Completion: 2026-02-26
Conditions
Cardiovascular Disease and Lipoprotein(a)
Interventions
DRUG
No Results Yet
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