Clinical Trials Updated in 2025

NCT05175105 | ACTIVE_NOT_RECRUITING | PHASE3

30 Participants

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-06-06

Completion: 2024-12-13

Conditions

Pediatric Pyruvate Kinase Deficiency Pediatric Hemolytic Anemia

Interventions

DRUG

No Results Yet

NCT05169515 | RECRUITING | PHASE1

121 Participants

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-10-26

Completion: 2029-09-15

Conditions

Non-Hodgkin Lymphoma

Interventions

DRUG

No Results Yet

NCT05157581 | RECRUITING

20 Participants

Extracorporeal Photopheresis in Sezary Syndrome

Study Type: OBSERVATIONAL

Last Updated: 2025-12-30

Start Date: 2023-04-04

Completion: 2028-12-31

Conditions

Sezary Syndrome

Interventions

DEVICE DRUG

No Results Yet

NCT05157074 | COMPLETED | NA

18 Participants

Group Drum-Based Music Therapy Intervention for Parkinson's Disease/Huntington's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2019-01-09

Completion: 2019-06-10

Conditions

Parkinson Disease Huntington Disease

Interventions

BEHAVIORAL

No Results Yet

NCT05151471 | TERMINATED | PHASE3

202 Participants

Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-01-11

Completion: 2023-09-29

Conditions

ALS

Interventions

DRUG

Results Available

NCT05144256 | ACTIVE_NOT_RECRUITING | PHASE3

49 Participants

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-06-08

Completion: 2024-05-03

Conditions

Pediatric Pyruvate Kinase Deficiency Pediatric Hemolytic Anemia

Interventions

DRUG

No Results Yet

NCT05135559 | ACTIVE_NOT_RECRUITING | PHASE3

153 Participants

A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-03-24

Completion: 2026-04-21

Conditions

Haemophilia A and B With and Without Inhibitors

Interventions

DRUG

No Results Yet

NCT05122013 | COMPLETED | NA

100 Participants

Remote Intervention for Weight Regain After Sleeve Gastrectomy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-02-18

Completion: 2023-12-01

Conditions

Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT05115994 | ACTIVE_NOT_RECRUITING

10000 Participants

Antihypertensive and PAP Treatment in Obstructive Sleep Apnea Patients With Hypertension (AHPAP)

Study Type: OBSERVATIONAL

Last Updated: 2025-12-30

Start Date: 2008-01-31

Completion: 2026-06-30

Conditions

Obstructive Sleep Apnea Hypertension Death, Cardiac Treatment Compliance Heart Failure Stroke

Interventions

DEVICE

No Results Yet

NCT05112809 | COMPLETED | NA

68 Participants

Noninvasive Cochlear Stimulation System

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2023-10-06

Completion: 2024-12-20

Conditions

Healthy

Interventions

DEVICE

Results Available

NCT05111574 | RECRUITING | PHASE2

99 Participants

Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-08-11

Completion: 2025-12-19

Conditions

Anal Melanoma Bladder Melanoma Cervical Melanoma Esophageal Melanoma Gallbladder Melanoma Head and Neck Mucosal Melanoma Mucosal Melanoma Nasopharyngeal Mucosal Melanoma Oral Cavity Mucosal Melanoma Penile Mucosal Melanoma Rectal Melanoma Recurrent Mucosal Melanoma Sinonasal Mucosal Melanoma Urethral Melanoma Urinary System Mucosal Melanoma Vaginal Melanoma Vulvar Melanoma

Interventions

PROCEDURE DRUG BIOLOGICAL

No Results Yet

NCT05109988 | COMPLETED | NA

649 Participants

Father-involvement Telephone Support Intervention on Breastfeeding: RCT

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-04-18

Completion: 2025-07-28

Conditions

Breast Feeding, Exclusive Parents

Interventions

BEHAVIORAL

No Results Yet

NCT05100082 | COMPLETED

263 Participants

Survey of Cabozantinib Tablets Used To Treat People With Hepatocellular Carcinoma

Study Type: OBSERVATIONAL

Last Updated: 2025-12-30

Start Date: 2021-11-17

Completion: 2025-11-30

Conditions

Hepatocellular Cancer

Interventions

DRUG

No Results Yet

NCT05090033 | ACTIVE_NOT_RECRUITING

103 Participants

Characterizing the Use of Ofatumumab in a Real World Setting

Study Type: OBSERVATIONAL

Last Updated: 2025-12-30

Start Date: 2022-12-08

Completion: 2025-12-31

Conditions

Relapsing Multiple Sclerosis

Interventions

OTHER

No Results Yet

NCT05079620 | TERMINATED | PHASE4

5 Participants

Early Antibiotics After Aspiration in ICU Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-11-30

Completion: 2024-04-12

Conditions

Aspiration Aspiration Pneumonia

Interventions

DRUG

Results Available

NCT05066347 | RECRUITING | NA

580 Participants

REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-07-01

Completion: 2027-07-30

Conditions

Syncope

Interventions

DEVICE

No Results Yet

NCT05035030 | RECRUITING | PHASE3

70 Participants

Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-09-03

Completion: 2026-12-31

Conditions

Alagille Syndrome

Interventions

DRUG

No Results Yet

NCT05029687 | COMPLETED | NA

64 Participants

Youth-Led Intervention to Improve Blood Pressure

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-10-31

Completion: 2023-06-30

Conditions

Hypertension Adolescent Behavior Health Knowledge, Attitudes, Practice

Interventions

BEHAVIORAL

Results Available

NCT05006079 | RECRUITING | PHASE2

24 Participants

Opioid/Benzodiazepine Polydrug Abuse: Aim 3

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2024-03-13

Completion: 2026-12-31

Conditions

Opioid Abuse Benzodiazepine Abuse Polysubstance Abuse

Interventions

DRUG

No Results Yet

NCT04999826 | COMPLETED

105 Participants

Multiscale Omics for the Development of a Cohort Database and Study Platform in Breast Cancer Survivors

Study Type: OBSERVATIONAL

Last Updated: 2025-12-30

Start Date: 2021-04-01

Completion: 2022-12-30

Conditions

Anatomic Stage 0 Breast Cancer AJCC v8 Anatomic Stage I Breast Cancer AJCC v8 Anatomic Stage IA Breast Cancer AJCC v8 Anatomic Stage IB Breast Cancer AJCC v8 Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage IIA Breast Cancer AJCC v8 Anatomic Stage IIB Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 Anatomic Stage IIIA Breast Cancer AJCC v8 Anatomic Stage IIIB Breast Cancer AJCC v8 Anatomic Stage IIIC Breast Cancer AJCC v8 Prognostic Stage 0 Breast Cancer AJCC v8 Prognostic Stage I Breast Cancer AJCC v8 Prognostic Stage IA Breast Cancer AJCC v8 Prognostic Stage IB Breast Cancer AJCC v8 Prognostic Stage II Breast Cancer AJCC v8 Prognostic Stage IIA Breast Cancer AJCC v8 Prognostic Stage IIB Breast Cancer AJCC v8 Prognostic Stage III Breast Cancer AJCC v8 Prognostic Stage IIIA Breast Cancer AJCC v8 Prognostic Stage IIIB Breast Cancer AJCC v8 Prognostic Stage IIIC Breast Cancer AJCC v8

Interventions

PROCEDURE OTHER

No Results Yet

NCT04998136 | COMPLETED | PHASE3

150 Participants

Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-08-15

Completion: 2023-10-16

Conditions

Obesity

Interventions

DRUG

Results Available

NCT04986852 | TERMINATED | PHASE2

19 Participants

Olinvacimab With Pembrolizumab in Patients With mTNBC

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-09-30

Completion: 2024-12-03

Conditions

Metastatic Triple-Negative Breast Cancer

Interventions

DRUG

No Results Yet

NCT04986072 | TERMINATED | PHASE2

1 Participants

Sodium Nitroprusside in Early Course Schizophrenia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-03-14

Completion: 2024-06-01

Conditions

Schizophrenia Schizoaffective Disorder

Interventions

DRUG

Results Available

NCT04978636 | ACTIVE_NOT_RECRUITING | NA

5502 Participants

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-09-20

Completion: 2026-12-31

Conditions

Cardiac Surgery

Interventions

OTHER

No Results Yet

NCT04965181 | COMPLETED | NA

504 Participants

Mindfulness-based Smoking Cessation Enhanced With Mobile Technology

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-07-01

Completion: 2025-01-09

Conditions

Cigarette Smoking

Interventions

BEHAVIORAL DRUG

Results Available

NCT04958265 | ACTIVE_NOT_RECRUITING | PHASE3

41 Participants

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-11-17

Completion: 2025-07-04

Conditions

Atypical Hemolytic Uremic Syndrome

Interventions

DRUG

No Results Yet

NCT04933903 | RECRUITING | PHASE2

25 Participants

BrUOG 397: NEO Rad (LOW): Neoadjuvant Low Dose Stereotactic Body Radiotherapy, Ipilimumab and Nivolumab

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-10-05

Completion: 2026-02-28

Conditions

Non Small Cell Lung Cancer

Interventions

DRUG RADIATION

No Results Yet

NCT04922320 | COMPLETED | NA

420 Participants

Effect of Patient Priorities Care Implementation in Older Veterans With Multiple Chronic Conditions

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-09-15

Completion: 2025-04-30

Conditions

Multiple Chronic Conditions Decision Making, Shared

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT04920864 | ACTIVE_NOT_RECRUITING | NA

32 Participants

rTMS, Stress and Opioid Use Disorder

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2022-04-01

Completion: 2024-08-08

Conditions

Opioid Use Disorder

Interventions

DEVICE

No Results Yet

NCT04919369 | ACTIVE_NOT_RECRUITING | PHASE1

18 Participants

All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-10-18

Completion: 2025-09-20

Conditions

Metastatic Lung Non-Small Cell Carcinoma Recurrent Lung Non-Small Cell Carcinoma Stage IV Lung Cancer AJCC v8 Stage IVA Lung Cancer AJCC v8 Stage IVB Lung Cancer AJCC v8

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT04893291 | ACTIVE_NOT_RECRUITING | NA

1820 Participants

Sirolimus-coated Balloon Versus Drug-eluting Stent in Native Coronary Vessels

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-11-16

Completion: 2026-08-30

Conditions

Coronary Artery Disease Coronary Artery Stenosis

Interventions

DEVICE

No Results Yet

NCT04870788 | RECRUITING | NA

60 Participants

Mindfulness-Based Intervention for Latino Cancer Patients and Their Caregivers

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2021-03-24

Completion: 2027-09-30

Conditions

Advanced Malignant Solid Neoplasm

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT04866459 | ENROLLING_BY_INVITATION

Study Type: INTERVENTIONAL

Last Updated: 2025-12-30

Start Date: 2020-08-27

Completion: 2022-03-07

Conditions

Covid19 SARS-CoV-2

Interventions

OTHER

No Results Yet