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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05251181 | NOT_YET_RECRUITING | PHASE3
430 Participants

A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative Agent

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2026-02-28
Completion: 2026-10-31
Conditions
Hypovolemic Shock
Interventions
DRUG
No Results Yet
NCT05243797 | RECRUITING | PHASE3
1594 Participants

Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-09-08
Completion: 2028-04-30
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05223868 | COMPLETED | PHASE2
255 Participants

A Study of JNJ-77242113 in Participants With Moderate-to-severe Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-02-03
Completion: 2022-12-15
Conditions
Plaque Psoriasis
Interventions
DRUG
Results Available
NCT05220033 | ACTIVE_NOT_RECRUITING | NA
30 Participants

Journey Ahead: Enhancing Coping and Communication for Women Diagnosed With Gynecological Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-07-14
Completion: 2026-07-01
Conditions
Gynecologic Cancer Ovarian Cancer Endometrial Cancer Fallopian Tube Cancer Cervical Cancer Uterine Cancer
Interventions
OTHER
No Results Yet
NCT05213130 | COMPLETED | NA
601 Participants

Blood Donation and Subjective Well-being

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-01-18
Completion: 2022-03-12
Conditions
Blood Donation Happiness
Interventions
OTHER
No Results Yet
NCT05175105 | ACTIVE_NOT_RECRUITING | PHASE3
30 Participants

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-06-06
Completion: 2024-12-13
Conditions
Pediatric Pyruvate Kinase Deficiency Pediatric Hemolytic Anemia
Interventions
DRUG
No Results Yet
NCT05169515 | RECRUITING | PHASE1
121 Participants

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-10-26
Completion: 2029-09-15
Conditions
Non-Hodgkin Lymphoma
Interventions
DRUG
No Results Yet
NCT05157581 | RECRUITING
20 Participants

Extracorporeal Photopheresis in Sezary Syndrome

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2023-04-04
Completion: 2028-12-31
Conditions
Sezary Syndrome
Interventions
DEVICE DRUG
No Results Yet
NCT05157074 | COMPLETED | NA
18 Participants

Group Drum-Based Music Therapy Intervention for Parkinson's Disease/Huntington's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2019-01-09
Completion: 2019-06-10
Conditions
Parkinson Disease Huntington Disease
Interventions
BEHAVIORAL
No Results Yet
NCT05151471 | TERMINATED | PHASE3
202 Participants

Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-01-11
Completion: 2023-09-29
Conditions
ALS
Interventions
DRUG
Results Available
NCT05144256 | ACTIVE_NOT_RECRUITING | PHASE3
49 Participants

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-06-08
Completion: 2024-05-03
Conditions
Pediatric Pyruvate Kinase Deficiency Pediatric Hemolytic Anemia
Interventions
DRUG
No Results Yet
NCT05135559 | ACTIVE_NOT_RECRUITING | PHASE3
153 Participants

A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-03-24
Completion: 2026-04-21
Conditions
Haemophilia A and B With and Without Inhibitors
Interventions
DRUG
No Results Yet
NCT05122013 | COMPLETED | NA
100 Participants

Remote Intervention for Weight Regain After Sleeve Gastrectomy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-02-18
Completion: 2023-12-01
Conditions
Obesity
Interventions
BEHAVIORAL
No Results Yet
NCT05115994 | ACTIVE_NOT_RECRUITING
10000 Participants

Antihypertensive and PAP Treatment in Obstructive Sleep Apnea Patients With Hypertension (AHPAP)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2008-01-31
Completion: 2026-06-30
Conditions
Obstructive Sleep Apnea Hypertension Death, Cardiac Treatment Compliance Heart Failure Stroke
Interventions
DEVICE
No Results Yet
NCT05112809 | COMPLETED | NA
68 Participants

Noninvasive Cochlear Stimulation System

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-10-06
Completion: 2024-12-20
Conditions
Healthy
Interventions
DEVICE
Results Available
NCT05111574 | RECRUITING | PHASE2
99 Participants

Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-08-11
Completion: 2025-12-19
Conditions
Anal Melanoma Bladder Melanoma Cervical Melanoma Esophageal Melanoma Gallbladder Melanoma Head and Neck Mucosal Melanoma Mucosal Melanoma Nasopharyngeal Mucosal Melanoma Oral Cavity Mucosal Melanoma Penile Mucosal Melanoma Rectal Melanoma Recurrent Mucosal Melanoma Sinonasal Mucosal Melanoma Urethral Melanoma Urinary System Mucosal Melanoma Vaginal Melanoma Vulvar Melanoma
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT05109988 | COMPLETED | NA
649 Participants

Father-involvement Telephone Support Intervention on Breastfeeding: RCT

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-04-18
Completion: 2025-07-28
Conditions
Breast Feeding, Exclusive Parents
Interventions
BEHAVIORAL
No Results Yet
NCT05100082 | COMPLETED
263 Participants

Survey of Cabozantinib Tablets Used To Treat People With Hepatocellular Carcinoma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2021-11-17
Completion: 2025-11-30
Conditions
Hepatocellular Cancer
Interventions
DRUG
No Results Yet
NCT05093335 | RECRUITING | EARLY_PHASE1
30 Participants

In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-01
Completion: 2026-10-31
Conditions
Non-Hodgkin Lymphoma Multiple Myeloma Histiocytic Neoplasms Erdheim-Chester Disease Rosai-Dorfman Disease
Interventions
DRUG
No Results Yet
NCT05090033 | ACTIVE_NOT_RECRUITING
103 Participants

Characterizing the Use of Ofatumumab in a Real World Setting

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2022-12-08
Completion: 2025-12-31
Conditions
Relapsing Multiple Sclerosis
Interventions
OTHER
No Results Yet
NCT05079620 | TERMINATED | PHASE4
5 Participants

Early Antibiotics After Aspiration in ICU Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-11-30
Completion: 2024-04-12
Conditions
Aspiration Aspiration Pneumonia
Interventions
DRUG
Results Available
NCT05066347 | RECRUITING | NA
580 Participants

REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-07-01
Completion: 2027-07-30
Conditions
Syncope
Interventions
DEVICE
No Results Yet
NCT05035030 | RECRUITING | PHASE3
70 Participants

Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-09-03
Completion: 2026-12-31
Conditions
Alagille Syndrome
Interventions
DRUG
No Results Yet
NCT05029687 | COMPLETED | NA
64 Participants

Youth-Led Intervention to Improve Blood Pressure

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-31
Completion: 2023-06-30
Conditions
Hypertension Adolescent Behavior Health Knowledge, Attitudes, Practice
Interventions
BEHAVIORAL
Results Available
NCT05006079 | RECRUITING | PHASE2
24 Participants

Opioid/Benzodiazepine Polydrug Abuse: Aim 3

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2024-03-13
Completion: 2026-12-31
Conditions
Opioid Abuse Benzodiazepine Abuse Polysubstance Abuse
Interventions
DRUG
No Results Yet
NCT04999826 | COMPLETED
105 Participants

Multiscale Omics for the Development of a Cohort Database and Study Platform in Breast Cancer Survivors

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2021-04-01
Completion: 2022-12-30
Conditions
Anatomic Stage 0 Breast Cancer AJCC v8 Anatomic Stage I Breast Cancer AJCC v8 Anatomic Stage IA Breast Cancer AJCC v8 Anatomic Stage IB Breast Cancer AJCC v8 Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage IIA Breast Cancer AJCC v8 Anatomic Stage IIB Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 Anatomic Stage IIIA Breast Cancer AJCC v8 Anatomic Stage IIIB Breast Cancer AJCC v8 Anatomic Stage IIIC Breast Cancer AJCC v8 Prognostic Stage 0 Breast Cancer AJCC v8 Prognostic Stage I Breast Cancer AJCC v8 Prognostic Stage IA Breast Cancer AJCC v8 Prognostic Stage IB Breast Cancer AJCC v8 Prognostic Stage II Breast Cancer AJCC v8 Prognostic Stage IIA Breast Cancer AJCC v8 Prognostic Stage IIB Breast Cancer AJCC v8 Prognostic Stage III Breast Cancer AJCC v8 Prognostic Stage IIIA Breast Cancer AJCC v8 Prognostic Stage IIIB Breast Cancer AJCC v8 Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions
PROCEDURE OTHER
No Results Yet
NCT04998136 | COMPLETED | PHASE3
150 Participants

Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-08-15
Completion: 2023-10-16
Conditions
Obesity
Interventions
DRUG
Results Available
NCT04986852 | TERMINATED | PHASE2
19 Participants

Olinvacimab With Pembrolizumab in Patients With mTNBC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-09-30
Completion: 2024-12-03
Conditions
Metastatic Triple-Negative Breast Cancer
Interventions
DRUG
No Results Yet
NCT04986072 | TERMINATED | PHASE2
1 Participants

Sodium Nitroprusside in Early Course Schizophrenia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-03-14
Completion: 2024-06-01
Conditions
Schizophrenia Schizoaffective Disorder
Interventions
DRUG
Results Available
NCT04978636 | ACTIVE_NOT_RECRUITING | NA
5502 Participants

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-09-20
Completion: 2026-12-31
Conditions
Cardiac Surgery
Interventions
OTHER
No Results Yet
NCT04965181 | COMPLETED | NA
504 Participants

Mindfulness-based Smoking Cessation Enhanced With Mobile Technology

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-07-01
Completion: 2025-01-09
Conditions
Cigarette Smoking
Interventions
BEHAVIORAL DRUG
Results Available
NCT04958265 | ACTIVE_NOT_RECRUITING | PHASE3
41 Participants

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-11-17
Completion: 2025-07-04
Conditions
Atypical Hemolytic Uremic Syndrome
Interventions
DRUG
No Results Yet
NCT04933903 | RECRUITING | PHASE2
25 Participants

BrUOG 397: NEO Rad (LOW): Neoadjuvant Low Dose Stereotactic Body Radiotherapy, Ipilimumab and Nivolumab

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-05
Completion: 2026-02-28
Conditions
Non Small Cell Lung Cancer
Interventions
DRUG RADIATION
No Results Yet
NCT04922320 | COMPLETED | NA
420 Participants

Effect of Patient Priorities Care Implementation in Older Veterans With Multiple Chronic Conditions

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-09-15
Completion: 2025-04-30
Conditions
Multiple Chronic Conditions Decision Making, Shared
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT04920864 | ACTIVE_NOT_RECRUITING | NA
32 Participants

rTMS, Stress and Opioid Use Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-04-01
Completion: 2024-08-08
Conditions
Opioid Use Disorder
Interventions
DEVICE
No Results Yet
NCT04919369 | ACTIVE_NOT_RECRUITING | PHASE1
18 Participants

All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-18
Completion: 2025-09-20
Conditions
Metastatic Lung Non-Small Cell Carcinoma Recurrent Lung Non-Small Cell Carcinoma Stage IV Lung Cancer AJCC v8 Stage IVA Lung Cancer AJCC v8 Stage IVB Lung Cancer AJCC v8
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT04893291 | ACTIVE_NOT_RECRUITING | NA
1820 Participants

Sirolimus-coated Balloon Versus Drug-eluting Stent in Native Coronary Vessels

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-11-16
Completion: 2026-08-30
Conditions
Coronary Artery Disease Coronary Artery Stenosis
Interventions
DEVICE
No Results Yet
NCT04870788 | RECRUITING | NA
60 Participants

Mindfulness-Based Intervention for Latino Cancer Patients and Their Caregivers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-03-24
Completion: 2027-09-30
Conditions
Advanced Malignant Solid Neoplasm
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT04866459 | ENROLLING_BY_INVITATION
1000 Participants

MYO-SHARE: MYO-MRI in Neuromuscular Diseases

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2022-05-12
Completion: 2031-05-30
Conditions
Neuromuscular Diseases
No Results Yet
NCT04855422 | RECRUITING
50 Participants

Assessing Benchmarks For Allosure And Allomap Testing in Simultaneous Kidney & Pancreas Transplant Recipients.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2021-07-14
Completion: 2026-12-31
Conditions
Transplant; Complication, Rejection
Interventions
DIAGNOSTIC_TEST
No Results Yet
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