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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05035030 | RECRUITING | PHASE3
70 Participants

Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-09-03
Completion: 2026-12-31
Conditions
Alagille Syndrome
Interventions
DRUG
No Results Yet
NCT05029687 | COMPLETED | NA
64 Participants

Youth-Led Intervention to Improve Blood Pressure

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-31
Completion: 2023-06-30
Conditions
Hypertension Adolescent Behavior Health Knowledge, Attitudes, Practice
Interventions
BEHAVIORAL
Results Available
NCT05006079 | RECRUITING | PHASE2
24 Participants

Opioid/Benzodiazepine Polydrug Abuse: Aim 3

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2024-03-13
Completion: 2026-12-31
Conditions
Opioid Abuse Benzodiazepine Abuse Polysubstance Abuse
Interventions
DRUG
No Results Yet
NCT04999826 | COMPLETED
105 Participants

Multiscale Omics for the Development of a Cohort Database and Study Platform in Breast Cancer Survivors

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2021-04-01
Completion: 2022-12-30
Conditions
Anatomic Stage 0 Breast Cancer AJCC v8 Anatomic Stage I Breast Cancer AJCC v8 Anatomic Stage IA Breast Cancer AJCC v8 Anatomic Stage IB Breast Cancer AJCC v8 Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage IIA Breast Cancer AJCC v8 Anatomic Stage IIB Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 Anatomic Stage IIIA Breast Cancer AJCC v8 Anatomic Stage IIIB Breast Cancer AJCC v8 Anatomic Stage IIIC Breast Cancer AJCC v8 Prognostic Stage 0 Breast Cancer AJCC v8 Prognostic Stage I Breast Cancer AJCC v8 Prognostic Stage IA Breast Cancer AJCC v8 Prognostic Stage IB Breast Cancer AJCC v8 Prognostic Stage II Breast Cancer AJCC v8 Prognostic Stage IIA Breast Cancer AJCC v8 Prognostic Stage IIB Breast Cancer AJCC v8 Prognostic Stage III Breast Cancer AJCC v8 Prognostic Stage IIIA Breast Cancer AJCC v8 Prognostic Stage IIIB Breast Cancer AJCC v8 Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions
PROCEDURE OTHER
No Results Yet
NCT04998136 | COMPLETED | PHASE3
150 Participants

Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-08-15
Completion: 2023-10-16
Conditions
Obesity
Interventions
DRUG
Results Available
NCT04986852 | TERMINATED | PHASE2
19 Participants

Olinvacimab With Pembrolizumab in Patients With mTNBC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-09-30
Completion: 2024-12-03
Conditions
Metastatic Triple-Negative Breast Cancer
Interventions
DRUG
No Results Yet
NCT04986072 | TERMINATED | PHASE2
1 Participants

Sodium Nitroprusside in Early Course Schizophrenia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-03-14
Completion: 2024-06-01
Conditions
Schizophrenia Schizoaffective Disorder
Interventions
DRUG
Results Available
NCT04978636 | ACTIVE_NOT_RECRUITING | NA
5502 Participants

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-09-20
Completion: 2026-12-31
Conditions
Cardiac Surgery
Interventions
OTHER
No Results Yet
NCT04965181 | COMPLETED | NA
504 Participants

Mindfulness-based Smoking Cessation Enhanced With Mobile Technology

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-07-01
Completion: 2025-01-09
Conditions
Cigarette Smoking
Interventions
BEHAVIORAL DRUG
Results Available
NCT04958265 | ACTIVE_NOT_RECRUITING | PHASE3
41 Participants

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-11-17
Completion: 2025-07-04
Conditions
Atypical Hemolytic Uremic Syndrome
Interventions
DRUG
No Results Yet
NCT04933903 | RECRUITING | PHASE2
25 Participants

BrUOG 397: NEO Rad (LOW): Neoadjuvant Low Dose Stereotactic Body Radiotherapy, Ipilimumab and Nivolumab

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-05
Completion: 2026-02-28
Conditions
Non Small Cell Lung Cancer
Interventions
DRUG RADIATION
No Results Yet
NCT04922320 | COMPLETED | NA
420 Participants

Effect of Patient Priorities Care Implementation in Older Veterans With Multiple Chronic Conditions

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-09-15
Completion: 2025-04-30
Conditions
Multiple Chronic Conditions Decision Making, Shared
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT04920864 | ACTIVE_NOT_RECRUITING | NA
32 Participants

rTMS, Stress and Opioid Use Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-04-01
Completion: 2024-08-08
Conditions
Opioid Use Disorder
Interventions
DEVICE
No Results Yet
NCT04919369 | ACTIVE_NOT_RECRUITING | PHASE1
18 Participants

All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-18
Completion: 2025-09-20
Conditions
Metastatic Lung Non-Small Cell Carcinoma Recurrent Lung Non-Small Cell Carcinoma Stage IV Lung Cancer AJCC v8 Stage IVA Lung Cancer AJCC v8 Stage IVB Lung Cancer AJCC v8
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT04893291 | ACTIVE_NOT_RECRUITING | NA
1820 Participants

Sirolimus-coated Balloon Versus Drug-eluting Stent in Native Coronary Vessels

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-11-16
Completion: 2026-08-30
Conditions
Coronary Artery Disease Coronary Artery Stenosis
Interventions
DEVICE
No Results Yet
NCT04870788 | RECRUITING | NA
60 Participants

Mindfulness-Based Intervention for Latino Cancer Patients and Their Caregivers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-03-24
Completion: 2027-09-30
Conditions
Advanced Malignant Solid Neoplasm
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT04866459 | ENROLLING_BY_INVITATION
1000 Participants

MYO-SHARE: MYO-MRI in Neuromuscular Diseases

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2022-05-12
Completion: 2031-05-30
Conditions
Neuromuscular Diseases
No Results Yet
NCT04855422 | RECRUITING
50 Participants

Assessing Benchmarks For Allosure And Allomap Testing in Simultaneous Kidney & Pancreas Transplant Recipients.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2021-07-14
Completion: 2026-12-31
Conditions
Transplant; Complication, Rejection
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04831320 | ACTIVE_NOT_RECRUITING | PHASE2
46 Participants

Nab-Paclitaxel in Combination With Nivolumab to Treat Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma That Progressed on a PD-1 or PD-L1 Inhibitor

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-09-28
Completion: 2026-06-30
Conditions
Metastatic Head-and-neck Squamous-cell Carcinoma
Interventions
DRUG
No Results Yet
NCT04792502 | RECRUITING | PHASE2
52 Participants

Mosunetuzumab With Lenalidomide Augmentation as First-line Therapy for Follicular and Marginal Zone Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-07-14
Completion: 2027-08-31
Conditions
Follicular Lymphoma Marginal Zone Lymphoma B-cell Lymphoma
Interventions
DRUG
No Results Yet
NCT04777396 | ACTIVE_NOT_RECRUITING | PHASE3
1840 Participants

A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-05-18
Completion: 2025-09-16
Conditions
Early Alzheimer's Disease
Interventions
DRUG
No Results Yet
NCT04765657 | ACTIVE_NOT_RECRUITING | PHASE3
345 Participants

Study of Efficacy and Safety of Inclisiran in Asian Participants With Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD High Risk and Elevated Low Density Lipoprotein Cholesterol (LDL-C)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-03-01
Completion: 2022-06-09
Conditions
Hypercholesterolemia
Interventions
DRUG
No Results Yet
NCT04758780 | COMPLETED | PHASE2
12 Participants

Imaging Performance Assessment of 89Zi-girentuximab (89Zr-TLX250) PET in Metastatic Triple Negative Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-09-21
Completion: 2023-03-31
Conditions
Triple Negative Breast Cancer
Interventions
DRUG
Results Available
NCT04750720 | COMPLETED | NA
187 Participants

Study of the Kinetics of COVID-19 Antibodies for 24 Months in Patients With Confirmed SARS-CoV-2 Infection

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-08-27
Completion: 2022-03-07
Conditions
Covid19 SARS-CoV-2
Interventions
OTHER
No Results Yet
NCT04731610 | RECRUITING | NA
314 Participants

Randomized, Multicenter, Phase III Trial to Assess Conformal Post-operative Radiotherapy vs. Surveillance After Complete Resection of Stage II/III Thymoma (RADIO-RYTHMIC-01)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2024-12-28
Completion: 2031-12-28
Conditions
Thymoma Malignant Recurrent
Interventions
OTHER
No Results Yet
NCT04730921 | COMPLETED | NA
486 Participants

Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-11-13
Completion: 2025-06-30
Conditions
Atrioventricular Block Left Bundle Branch Area Pacing Right Ventricular Pacing Heart Failure
Interventions
DEVICE
No Results Yet
NCT04684485 | COMPLETED | PHASE2
250 Participants

To Assess the Efficacy and Safety of SCD-044 in the Treatment of Moderate to Severe Atopic Dermatitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-07-30
Completion: 2024-11-11
Conditions
Dermatitis, Atopic
Interventions
DRUG
Results Available
NCT04648254 | COMPLETED | PHASE1
51 Participants

Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor in Patients With Advanced Solid Tumor

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-11-18
Completion: 2025-12-23
Conditions
Solid Tumor Advanced Cancer Metastatic Cancer
Interventions
DRUG
No Results Yet
NCT04639180 | ACTIVE_NOT_RECRUITING | PHASE3
687 Participants

A Study to Evaluate Camrelizumab Plus Rivoceranib (Apatinib) as Adjuvant Therapy in Patients With Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection or Ablation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-04-01
Completion: 2026-07-31
Conditions
Hepatocellular Carcinoma (HCC)
Interventions
DRUG
No Results Yet
NCT04626596 | COMPLETED | PHASE3
498 Participants

A Study to Assess Contraceptive Efficacy and Safety of Etonogestrel (ENG) Implant Beyond 3 Years of Use (MK-8415-060)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-11-19
Completion: 2024-12-30
Conditions
Contraception
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT04604067 | ACTIVE_NOT_RECRUITING | PHASE2
260 Participants

Assessing a ctDNA and PET-oriented Therapy in Patients With DLBCL A Multicenter, Open-label, Phase II Trial.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-06-25
Completion: 2026-07-30
Conditions
Diffuse Large B-cell Lymphoma
Interventions
DRUG
No Results Yet
NCT04597359 | RECRUITING | PHASE2
360 Participants

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-10-05
Completion: 2032-12-31
Conditions
Prostate Carcinoma
Interventions
DRUG OTHER
No Results Yet
NCT04582201 | COMPLETED | PHASE1
20 Participants

A Clinical Trial to Evaluate the Safety of agenT-797 in COVID-19 Participants With ARDS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-09-21
Completion: 2023-04-23
Conditions
Respiratory Distress Syndrome, Adult
Interventions
DRUG
No Results Yet
NCT04577404 | COMPLETED | PHASE3
124 Participants

Safety Extension Study of Oral Edaravone Administered in Subjects With Amyotrophic Lateral Sclerosis (ALS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-10-29
Completion: 2023-08-09
Conditions
Amyotrophic Lateral Sclerosis (ALS)
Interventions
DRUG
Results Available
NCT04573439 | RECRUITING | NA
30 Participants

Protein Requirements for Active Children

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-08-16
Completion: 2026-06-30
Conditions
Healthy
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT04569084 | TERMINATED | PHASE3
384 Participants

Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-11-13
Completion: 2023-09-29
Conditions
ALS
Interventions
DRUG
Results Available
NCT04569032 | ACTIVE_NOT_RECRUITING | PHASE2
82 Participants

A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2020-11-12
Completion: 2024-05-09
Conditions
Peripheral T-cell Lymphoma
Interventions
DRUG
Results Available
NCT04566328 | RECRUITING | PHASE3
1450 Participants

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-02-24
Completion: 2027-12-31
Conditions
Plasma Cell Myeloma RISS Stage I Plasma Cell Myeloma RISS Stage II Plasma Cell Myeloma
Interventions
DRUG BIOLOGICAL OTHER
No Results Yet
NCT04490564 | COMPLETED
135 Participants

Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood and Primary Tumor in HNSCC/NSCLC/Melanoma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2019-06-25
Completion: 2022-09-07
Conditions
Head and Neck Squamous Cell Carcinoma Non Small Cell Lung Cancer Melanoma
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04484818 | ACTIVE_NOT_RECRUITING | PHASE3
27 Participants

Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2021-03-01
Completion: 2026-06-30
Conditions
Prostate Carcinoma
Interventions
DRUG OTHER
No Results Yet
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