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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06184581 | RECRUITING | PHASE4
200 Participants

Lithium Versus Lamotrigine in Bipolar Disorder, Type II

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-05-08
Completion: 2027-12-01
Conditions
Bipolar II Disorder
Interventions
DRUG
No Results Yet
NCT06184321 | RECRUITING | EARLY_PHASE1
30 Participants

Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-08-17
Completion: 2027-02-02
Conditions
Hematopoietic and Lymphoid Cell Neoplasm Malignant Solid Neoplasm
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06179888 | RECRUITING | PHASE2
78 Participants

Iberdomide Versus Observation Off Therapy After Idecabtagene Vicleucel CAR-T for Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-08-27
Completion: 2027-10-31
Conditions
Multiple Myeloma
Interventions
PROCEDURE DRUG
No Results Yet
NCT06176352 | ACTIVE_NOT_RECRUITING | PHASE3
280 Participants

A Study to Evaluate the Efficacy and Safety of Faricimab in Patients With Choroidal Neovascularization Secondary to Pathologic Myopia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-03-06
Completion: 2025-09-11
Conditions
Choroidal Neovascularization Secondary to Pathologic Myopia
Interventions
DRUG PROCEDURE
No Results Yet
NCT06175832 | RECRUITING | PHASE4
60 Participants

PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-01-27
Completion: 2027-12-31
Conditions
Ovarian Stimulation Quality of Life Preimplantation Genetic Testing Fertility Preservation
Interventions
DRUG
No Results Yet
NCT06172296 | RECRUITING | PHASE3
478 Participants

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-04-19
Completion: 2029-12-31
Conditions
Ganglioneuroblastoma, Nodular Neuroblastoma
Interventions
PROCEDURE DRUG BIOLOGICAL RADIATION OTHER
No Results Yet
NCT06169215 | ACTIVE_NOT_RECRUITING | PHASE2
70 Participants

Comparing the Combination of Selinexor-Daratumumab-Velcade-Dexamethasone (Dara-SVD) With the Usual Treatment (Dara-RVD) for High-Risk Newly Diagnosed Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-23
Completion: 2026-09-30
Conditions
Multiple Myeloma
Interventions
PROCEDURE DRUG
No Results Yet
NCT06159517 | TERMINATED
184 Participants

Heart Lung Machine Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-12-21
Completion: 2025-04-30
Conditions
Cardiac Surgery Thoracic Surgery Vascular Surgery Cardiopulmonary Bypass
No Results Yet
NCT06148935 | RECRUITING
3000 Participants

An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-30
Completion: 2027-03-31
Conditions
Chronic Heart Failure With Reduced Ejection Fraction
Interventions
DRUG
No Results Yet
NCT06142981 | COMPLETED | NA
30 Participants

PRP and PBD-VSEL Stem Cell Therapy for Parkinson's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2019-09-10
Completion: 2022-09-15
Conditions
Regenerative Medicine
Interventions
BIOLOGICAL
No Results Yet
NCT06129539 | ACTIVE_NOT_RECRUITING | PHASE3
56 Participants

A Study to Assess the Efficacy, Safety, and Pharmacokinetics of Debio 4326 in Pediatric Participants With Central Precocious Puberty (LIBELULA™ Clinical Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-31
Completion: 2026-10-31
Conditions
Central Precocious Puberty
Interventions
DRUG
No Results Yet
NCT06126276 | RECRUITING | PHASE2
70 Participants

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-05-07
Completion: 2027-02-20
Conditions
Malignant Female Reproductive System Neoplasm Malignant Solid Neoplasm Recurrent Malignant Female Reproductive System Neoplasm Recurrent Malignant Solid Neoplasm
Interventions
PROCEDURE DRUG
No Results Yet
NCT06124157 | RECRUITING | PHASE3
222 Participants

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-05-30
Completion: 2030-12-01
Conditions
B Acute Lymphoblastic Leukemia
Interventions
PROCEDURE BIOLOGICAL DRUG RADIATION
No Results Yet
NCT06119061 | RECRUITING | PHASE4
20 Participants

Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-02
Completion: 2026-12-31
Conditions
Subarachnoid Hemorrhage, Aneurysmal
Interventions
DRUG
No Results Yet
NCT06117527 | RECRUITING
50 Participants

Placental Learning Model for Neurovascular Microsurgery for the Management of Intracranial Aneurysms

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-07-16
Completion: 2028-02-29
Conditions
Intracranial Aneurysm
No Results Yet
NCT06109948 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1
46 Participants

Study to Assess the Safety, Tolerability, PK and PD of ABX1100

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-10-19
Completion: 2026-02-28
Conditions
Healthy Late Onset Pompe Disease
Interventions
DRUG
No Results Yet
NCT06103838 | RECRUITING | PHASE2
60 Participants

18F-Fluciclovine PET/CT in Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-03-25
Completion: 2026-12-06
Conditions
Multiple Myeloma Newly Diagnosed Multiple Myeloma (NDMM) Relapsed and/or Refractory Multiple Myeloma (RRMM)
Interventions
DRUG PROCEDURE
No Results Yet
NCT06096844 | RECRUITING | PHASE3
304 Participants

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-19
Completion: 2026-06-01
Conditions
Advanced Lung Non-Small Cell Carcinoma Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8 Stage IV Lung Cancer AJCC v8
Interventions
DRUG PROCEDURE BIOLOGICAL OTHER
No Results Yet
NCT06090669 | RECRUITING | PHASE1
75 Participants

Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-12-19
Completion: 2026-10-30
Conditions
Inherited Bone Marrow Failure Syndrome Familial Platelet Disorder With Predisposition to Myeloid Malignancies
Interventions
DRUG DEVICE
No Results Yet
NCT06075524 | RECRUITING
500 Participants

Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2015-06-15
Completion: 2026-12-31
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Locally Advanced Lung Carcinoma Locally Advanced Malignant Solid Neoplasm Locally Advanced Melanoma Metastatic Lung Carcinoma Metastatic Malignant Solid Neoplasm Metastatic Melanoma Stage III Lung Cancer AJCC v8 Stage IV Lung Cancer AJCC v8
Interventions
PROCEDURE OTHER
No Results Yet
NCT06073158 | COMPLETED | NA
6 Participants

Molecular Signatures of Esophageal Atresia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-09-01
Completion: 2024-03-04
Conditions
Esophageal Atresia
Interventions
PROCEDURE
No Results Yet
NCT06071299 | ACTIVE_NOT_RECRUITING | NA
200 Participants

Impact of Family-Centered Care for Intimate Partner Violence (IPV)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-01-10
Completion: 2026-02-15
Conditions
Intimate Partner Violence
Interventions
BEHAVIORAL
No Results Yet
NCT06064097 | RECRUITING | PHASE2
50 Participants

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-25
Completion: 2026-12-31
Conditions
Stage II Nasopharyngeal Carcinoma AJCC v8 Stage III Nasopharyngeal Carcinoma AJCC v8 Stage IV Nasopharyngeal Carcinoma AJCC v8
Interventions
PROCEDURE DRUG OTHER BIOLOGICAL RADIATION
No Results Yet
NCT06058377 | RECRUITING | PHASE3
3680 Participants

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-27
Completion: 2026-05-31
Conditions
Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 HER2-Negative Breast Carcinoma Hormone Receptor-Positive Breast Carcinoma
Interventions
PROCEDURE DRUG BIOLOGICAL OTHER
No Results Yet
NCT06057948 | RECRUITING | PHASE2
94 Participants

A Study of a Vaccine in Combination With Beta-glucan in People With Neuroblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-09-21
Completion: 2026-03-21
Conditions
Neuroblastoma High-risk Neuroblastoma Metastatic Neuroblastoma
Interventions
BIOLOGICAL DIETARY_SUPPLEMENT
No Results Yet
NCT06054607 | COMPLETED | NA
21 Participants

Effect of Short-chain Fatty Acids on Aerobic Endurance

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-07-21
Completion: 2025-05-01
Conditions
Aerobic Endurance Metabolism
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT06053749 | ACTIVE_NOT_RECRUITING
4 Participants

An Observational Study to Learn About the Interferon-beta Exposure of Pregnant Women During the Second and Third Trimester in Finland and Sweden

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-03-20
Completion: 2026-03-31
Conditions
Multiple Sclerosis (MS)
Interventions
DRUG
No Results Yet
NCT06052631 | RECRUITING
16 Participants

Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2026-12-31
Conditions
PIEZO2-Deficiency Syndrome
No Results Yet
NCT06052254 | RECRUITING | PHASE2
150 Participants

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-09-16
Completion: 2027-01-31
Conditions
Agitation
Interventions
DRUG
No Results Yet
NCT06052059 | ACTIVE_NOT_RECRUITING | PHASE3
1020 Participants

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-10-25
Completion: 2026-08-01
Conditions
Ulcerative Colitis
Interventions
DRUG
No Results Yet
NCT06041503 | NOT_YET_RECRUITING | PHASE2
68 Participants

Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2027-10-01
Conditions
Adenocarcinoma of the Bladder Squamous Cell Carcinoma of the Bladder Testicular Germ Cell Tumors
Interventions
DRUG
No Results Yet
NCT06032143 | ACTIVE_NOT_RECRUITING | NA
120 Participants

Doulas as Environmental Educators and Partners Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-10-20
Completion: 2026-01-30
Conditions
Health Knowledge, Attitudes, Practice
Interventions
BEHAVIORAL
No Results Yet
NCT06029972 | RECRUITING | PHASE2
176 Participants

Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-12-05
Completion: 2026-04-30
Conditions
Ulcerative Colitis
Interventions
DRUG
No Results Yet
NCT06029270 | RECRUITING | PHASE2
156 Participants

Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-15
Completion: 2029-04-30
Conditions
Metastatic Nasopharyngeal Carcinoma Recurrent Nasopharyngeal Carcinoma Stage IV Nasopharyngeal Carcinoma AJCC v8
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT06024317 | NOT_YET_RECRUITING | NA
800 Participants

Leveraging Community Health Workers and a Digital Health System to Improve the Timeliness of Child Well Visits

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-03-01
Completion: 2027-07-31
Conditions
Short Message Service (SMS) Incentives Knowledge, Attitudes, Practice Preventive Services
Interventions
BEHAVIORAL
No Results Yet
NCT06019767 | COMPLETED | NA
59 Participants

Peer-led Trauma Therapy for Re-entry

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-14
Completion: 2025-12-12
Conditions
PTSD
Interventions
BEHAVIORAL
No Results Yet
NCT06015009 | COMPLETED | NA
40 Participants

Symptom Management App for Children at the Early Stage of Cancer Survivorship and Their Caregivers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-08-17
Completion: 2025-01-02
Conditions
Oncology Survivorship
Interventions
OTHER
No Results Yet
NCT06012149 | ACTIVE_NOT_RECRUITING | NA
208 Participants

Braining: Implementation of Physical Exercise for Patients in Specialist Psychiatry

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-09-27
Completion: 2026-06-30
Conditions
Mental Disorders
Interventions
BEHAVIORAL
No Results Yet
NCT06009926 | ACTIVE_NOT_RECRUITING | PHASE2
66 Participants

Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-12-04
Completion: 2027-03-31
Conditions
Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm Occupational Malignant Neoplasm
Interventions
DRUG PROCEDURE DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT06008938 | RECRUITING
500 Participants

An Observational Cohort Study to Characterize the Effectiveness and Safety of HEMGENIX® in Patients With Hemophilia B

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-06-15
Completion: 2043-08-01
Conditions
Hemophilia B
Interventions
GENETIC BIOLOGICAL
No Results Yet
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