Clinical Trials Updated in 2025

NCT06311383 | COMPLETED

2610 Participants

A Non-interventional Study for Women With HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer to Evaluate the Real-world Effectiveness of Treatment Algorithms Beginning With Ribociclib + AI/FUL, or With Endocrine Therapy or Chemotherapy as First Line Treatment

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2017-10-09

Completion: 2025-02-16

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT06311188 | NOT_YET_RECRUITING | NA

90 Participants

Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2026-01-26

Conditions

Stress Trauma PTSD HPA

Interventions

BEHAVIORAL

No Results Yet

NCT06307470 | COMPLETED | NA

43 Participants

Nurse-led Mind-body Intervention on Sexual Health for Breast Cancer Survivors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-10-15

Completion: 2025-11-30

Conditions

Women's Health: Neoplasm of Breast Menopause, Premature Body Image Sexual Dysfunction Cancer, Breast

Interventions

BEHAVIORAL

No Results Yet

NCT06286046 | NOT_YET_RECRUITING | PHASE2

40 Participants

A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2026-03-31

Completion: 2027-05-31

Conditions

Sickle Cell Disease Nephropathy

Interventions

DRUG

No Results Yet

NCT06271616 | RECRUITING | PHASE2

40 Participants

Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-12-13

Completion: 2027-06-30

Conditions

Chronic Graft Versus Host Disease Hematopoietic and Lymphatic System Neoplasm

Interventions

PROCEDURE DRUG

No Results Yet

NCT06269627 | RECRUITING | PHASE4

48 Participants

Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-05-07

Completion: 2025-12-31

Conditions

Alcohol Use Disorder

Interventions

DRUG OTHER

No Results Yet

NCT06263543 | RECRUITING | PHASE2

75 Participants

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-06-17

Completion: 2026-06-30

Conditions

Advanced Breast Cancer Metastatic Breast Cancer Breast Cancer Hormone-receptor-positive Breast Cancer Human Epidermal Growth Factor 2 Low Breast Cancer

Interventions

DRUG

No Results Yet

NCT06263270 | COMPLETED | PHASE1

19 Participants

Evaluation of CYT-108, A Recombinant Protease Inhibitor, for Treatment of Mild To Moderate Primary Osteoarthritis Of The Knee

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-06-01

Completion: 2025-03-15

Conditions

Osteoarthritis, Knee Osteoarthritis

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT06252753 | RECRUITING

4490 Participants

Observational Study Protocol: LIVER-R

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2023-03-16

Completion: 2030-12-30

Conditions

Hepatobiliary Cancers

Interventions

OTHER

No Results Yet

NCT06241313 | RECRUITING | PHASE3

1300 Participants

Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-03-25

Completion: 2025-07-07

Conditions

Migraine

Interventions

DRUG

No Results Yet

NCT06212570 | NOT_YET_RECRUITING | NA

12 Participants

KeyScope Study in Uganda

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2026-04-01

Completion: 2027-03-30

Conditions

Abdominal Neoplasm

Interventions

DEVICE

No Results Yet

NCT06206746 | RECRUITING | NA

195 Participants

The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-03-25

Completion: 2026-06-30

Conditions

Polycystic Ovary Syndrome Infertility, Female

Interventions

DEVICE

No Results Yet

NCT06200207 | RECRUITING | PHASE3

680 Participants

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-04-01

Completion: 2026-10-05

Conditions

Heart Failure Systemic Inflammation

Interventions

DRUG

No Results Yet

NCT06196463 | COMPLETED | NA

11 Participants

Erector Spinae Plane (ESP) Block in Juvenile Idiopathic Scoliosis Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-09-11

Completion: 2024-12-11

Conditions

Juvenile Idiopathic Scoliosis, Multiple Sites in Spine

Interventions

PROCEDURE

No Results Yet

NCT06184581 | RECRUITING | PHASE4

200 Participants

Lithium Versus Lamotrigine in Bipolar Disorder, Type II

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-05-08

Completion: 2027-12-01

Conditions

Bipolar II Disorder

Interventions

DRUG

No Results Yet

NCT06184321 | RECRUITING | EARLY_PHASE1

30 Participants

Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-08-17

Completion: 2027-02-02

Conditions

Hematopoietic and Lymphoid Cell Neoplasm Malignant Solid Neoplasm

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06176352 | ACTIVE_NOT_RECRUITING | PHASE3

280 Participants

A Study to Evaluate the Efficacy and Safety of Faricimab in Patients With Choroidal Neovascularization Secondary to Pathologic Myopia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-03-06

Completion: 2025-09-11

Conditions

Choroidal Neovascularization Secondary to Pathologic Myopia

Interventions

DRUG PROCEDURE

No Results Yet

NCT06175832 | RECRUITING | PHASE4

60 Participants

PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-01-27

Completion: 2027-12-31

Conditions

Ovarian Stimulation Quality of Life Preimplantation Genetic Testing Fertility Preservation

Interventions

DRUG

No Results Yet

NCT06159517 | TERMINATED

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2020-07-16

Completion: 2028-02-29

Conditions

Intracranial Aneurysm

No Results Yet

NCT06109948 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

46 Participants

Study to Assess the Safety, Tolerability, PK and PD of ABX1100

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-10-19

Completion: 2026-02-28

Conditions

Healthy Late Onset Pompe Disease

Interventions

DRUG

No Results Yet

NCT06103838 | RECRUITING | PHASE2

60 Participants

18F-Fluciclovine PET/CT in Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-03-25

Completion: 2026-12-06

Conditions

Multiple Myeloma Newly Diagnosed Multiple Myeloma (NDMM) Relapsed and/or Refractory Multiple Myeloma (RRMM)

Interventions

DRUG PROCEDURE

No Results Yet

NCT06090669 | RECRUITING | PHASE1

75 Participants

Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-12-19

Completion: 2026-10-30

Conditions

Inherited Bone Marrow Failure Syndrome Familial Platelet Disorder With Predisposition to Myeloid Malignancies

Interventions

DRUG DEVICE

No Results Yet

NCT06075524 | RECRUITING

500 Participants

Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2015-06-15

Completion: 2026-12-31

Conditions

Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Locally Advanced Lung Carcinoma Locally Advanced Malignant Solid Neoplasm Locally Advanced Melanoma Metastatic Lung Carcinoma Metastatic Malignant Solid Neoplasm Metastatic Melanoma Stage III Lung Cancer AJCC v8 Stage IV Lung Cancer AJCC v8

Interventions

PROCEDURE OTHER

No Results Yet

NCT06073158 | COMPLETED | NA

6 Participants

Molecular Signatures of Esophageal Atresia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-09-01

Completion: 2024-03-04

Conditions

Esophageal Atresia

Interventions

PROCEDURE

No Results Yet

NCT06071299 | ACTIVE_NOT_RECRUITING | NA

200 Participants

Impact of Family-Centered Care for Intimate Partner Violence (IPV)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-01-10

Completion: 2026-02-15

Conditions

Intimate Partner Violence

Interventions

BEHAVIORAL

No Results Yet

NCT06057948 | RECRUITING | PHASE2

94 Participants

A Study of a Vaccine in Combination With Beta-glucan in People With Neuroblastoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-09-21

Completion: 2026-03-21

Conditions

Neuroblastoma High-risk Neuroblastoma Metastatic Neuroblastoma

Interventions

BIOLOGICAL DIETARY_SUPPLEMENT

No Results Yet

NCT06054607 | COMPLETED | NA

21 Participants

Effect of Short-chain Fatty Acids on Aerobic Endurance

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-07-21

Completion: 2025-05-01

Conditions

Aerobic Endurance Metabolism

Interventions

DIETARY_SUPPLEMENT OTHER

No Results Yet

NCT06053749 | ACTIVE_NOT_RECRUITING

4 Participants

An Observational Study to Learn About the Interferon-beta Exposure of Pregnant Women During the Second and Third Trimester in Finland and Sweden

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2024-03-20

Completion: 2026-03-31

Conditions

Multiple Sclerosis (MS)

Interventions

DRUG

No Results Yet

NCT06052254 | RECRUITING | PHASE2

150 Participants

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-09-16

Completion: 2027-01-31

Conditions

Agitation

Interventions

DRUG

No Results Yet

NCT06052059 | ACTIVE_NOT_RECRUITING | PHASE3

1020 Participants

A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-10-25

Completion: 2026-08-01

Conditions

Ulcerative Colitis

Interventions

DRUG

No Results Yet

NCT06032143 | ACTIVE_NOT_RECRUITING | NA

120 Participants

Doulas as Environmental Educators and Partners Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-10-20

Completion: 2026-01-30

Conditions

Health Knowledge, Attitudes, Practice

Interventions

BEHAVIORAL

No Results Yet

NCT06029972 | RECRUITING | PHASE2

176 Participants

Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-12-05

Completion: 2026-04-30

Conditions

Ulcerative Colitis

Interventions

DRUG

No Results Yet

NCT06024317 | NOT_YET_RECRUITING | NA

800 Participants

Leveraging Community Health Workers and a Digital Health System to Improve the Timeliness of Child Well Visits

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2026-03-01

Completion: 2027-07-31

Conditions

Short Message Service (SMS) Incentives Knowledge, Attitudes, Practice Preventive Services

Interventions

BEHAVIORAL

No Results Yet

NCT06019767 | COMPLETED | NA

59 Participants

Peer-led Trauma Therapy for Re-entry

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-11-14

Completion: 2025-12-12

Conditions

PTSD

Interventions

BEHAVIORAL

No Results Yet

NCT06015009 | COMPLETED | NA

40 Participants

Symptom Management App for Children at the Early Stage of Cancer Survivorship and Their Caregivers

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2023-08-17

Completion: 2025-01-02

Conditions

Oncology Survivorship

Interventions

OTHER

No Results Yet