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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05413005 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1
10 Participants

Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Type 1 Diabetes Mellitus

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-09-05
Completion: 2026-09-01
Conditions
Type 1 Diabetes
Interventions
BIOLOGICAL COMBINATION_PRODUCT
No Results Yet
NCT05411094 | RECRUITING | PHASE1
18 Participants

Testing the Safety of the Anti-Cancer Drugs Durvalumab and Olaparib During Radiation Therapy for Locally Advanced Unresectable Pancreatic Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-05-22
Completion: 2026-07-01
Conditions
Locally Advanced Pancreatic Carcinoma Stage II Pancreatic Cancer AJCC v8 Stage III Pancreatic Cancer AJCC v8 Unresectable Pancreatic Carcinoma
Interventions
PROCEDURE BIOLOGICAL DRUG
No Results Yet
NCT05411081 | RECRUITING | PHASE2
200 Participants

Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer, PAPMET2 Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-03-24
Completion: 2027-07-01
Conditions
Metastatic Papillary Renal Cell Carcinoma Stage IV Renal Cell Cancer AJCC v8
Interventions
BIOLOGICAL PROCEDURE DRUG
No Results Yet
NCT05406037 | RECRUITING
100 Participants

Biomarkers for Invasive Mucormycosis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-29
Completion: 2026-07-31
Conditions
Mucorales Infection Mucormycosis
Interventions
BIOLOGICAL
No Results Yet
NCT05405491 | ACTIVE_NOT_RECRUITING | NA
31 Participants

Impact of a Strategy Based on Bacterial DNA Detection to Optimize Antibiotics in Immunocompromised Patients With Hospital-acquired Pneumonia Requiring Mechanical Ventilation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-03-28
Completion: 2028-03-31
Conditions
Pneumonia, Ventilator-Associated Pneumonia, Hospital-Acquired Immunodeficiency
Interventions
OTHER
No Results Yet
NCT05403866 | COMPLETED | PHASE2
89 Participants

A Study to Evaluate the Safety and Efficacy of Multiple Doses of LT3001 Drug Product in AIS Subjects

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-08-17
Completion: 2025-05-23
Conditions
Acute Ischemic Stroke
Interventions
DRUG
Results Available
NCT05400603 | RECRUITING | PHASE1
24 Participants

Allogeneic Expanded Gamma Delta T Cells With GD2 Chemoimmunotherapy in Relapsed /Refractory Neuroblastoma or Refractory/ Relapsed Osteosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-06
Completion: 2026-12-31
Conditions
Neuroblastoma Refractory Neuroblastoma Relapsed Neuroblastoma Relapsed Osteosarcoma Refractory Osteosarcoma
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05392556 | COMPLETED | NA
73 Participants

Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-07-06
Completion: 2025-10-28
Conditions
Stress Physiology
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT05375812 | RECRUITING
85 Participants

NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-04-16
Completion: 2030-12-31
Conditions
Gulf War Illness
No Results Yet
NCT05372627 | NOT_YET_RECRUITING
1000 Participants

NHLBI-Emory Advanced Cardiac CT Reconstruction

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2031-01-30
Conditions
Structural Heart Disease
No Results Yet
NCT05357742 | COMPLETED | NA
50 Participants

Basic Needs Navigation Intervention to Address Multidimensional Adversity in African Americans With Diabetic Kidney Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-08-01
Completion: 2025-07-31
Conditions
Diabetic Nephropathies Diabetes Mellitus, Type 2 Chronic Kidney Diseases Healthy Lifestyle
Interventions
BEHAVIORAL
No Results Yet
NCT05353439 | RECRUITING | PHASE1
60 Participants

Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-07-27
Completion: 2027-04-01
Conditions
Extensive Stage Lung Small Cell Carcinoma Limited Stage Lung Small Cell Carcinoma Platinum-Resistant Lung Small Cell Carcinoma Platinum-Sensitive Lung Small Cell Carcinoma Recurrent Extensive Stage Lung Small Cell Carcinoma Recurrent Lung Small Cell Carcinoma
Interventions
PROCEDURE BIOLOGICAL DRUG
No Results Yet
NCT05353153 | COMPLETED | NA
60 Participants

The Psychological Experience of Pathological Pregnancy. Study of the Case of Premature Rupture of Membranes and Evaluation of the Impact of Hypnosis Support

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-06-03
Completion: 2025-01-10
Conditions
Preterm Premature Rupture of Membrane
Interventions
OTHER
No Results Yet
NCT05348876 | RECRUITING | PHASE4
50 Participants

A Study to Learn More About How Safe Darolutamide is and How Well it Works Under Real World Conditions When Taken in Addition to Standard Androgen Deprivation Therapy (ADT) in Indian Participants With High-risk Non-metastatic Castration-resistant Prostate Cancer (nmCRPC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-08-03
Completion: 2026-01-28
Conditions
Non-metastatic Castration-resistant Prostate Cancer
Interventions
DRUG
No Results Yet
NCT05333458 | RECRUITING | PHASE2
27 Participants

Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, The AXIOM Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-08-29
Completion: 2027-05-01
Conditions
Advanced Alveolar Soft Part Sarcoma Advanced Soft Tissue Sarcoma Metastatic Alveolar Soft Part Sarcoma Refractory Alveolar Soft Part Sarcoma Unresectable Alveolar Soft Part Sarcoma
Interventions
BIOLOGICAL PROCEDURE DRUG
No Results Yet
NCT05327270 | ACTIVE_NOT_RECRUITING | PHASE1
18 Participants

Non-randomized, Open-label Study of Intralesional Nivolumab for High Risk Oral Premalignant Lesions

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-09-13
Completion: 2027-02-02
Conditions
Head and Neck Cancer
Interventions
DRUG
No Results Yet
NCT05324358 | COMPLETED | PHASE3
341 Participants

Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-12-14
Completion: 2024-09-06
Conditions
Pain, Postoperative
Interventions
DRUG OTHER
No Results Yet
NCT05304091 | WITHDRAWN
0 Participants

Characterization of Rhythmicity Profiles of Bradykinin-mediated Angioedema Attacks Using a Tracking Smartphone Application.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-08-31
Completion: 2023-08-31
Conditions
Bradykinin-mediated Angioedema
Interventions
OTHER
No Results Yet
NCT05304065 | RECRUITING | PHASE2
1600 Participants

Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-10-17
Completion: 2026-12-31
Conditions
Suicide and Self-harm
Interventions
BEHAVIORAL
No Results Yet
NCT05303467 | RECRUITING | PHASE1
36 Participants

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-07-30
Completion: 2026-03-31
Conditions
Glioblastoma Multiforme Recurrent Glioblastoma
Interventions
DEVICE
No Results Yet
NCT05295095 | RECRUITING | NA
264 Participants

Does Positive Pressure Extubation Reduce Postoperative Desaturation?

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-06-29
Completion: 2026-06-30
Conditions
Extubation Postoperative Complications Lung Ultrasound Score
Interventions
PROCEDURE
No Results Yet
NCT05281835 | RECRUITING
1000 Participants

Follow-up of Elderly Subjects With Falls Recruited in the Geriatric Departments of Several French Hospitals

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-06-16
Completion: 2026-03-31
Conditions
Falls in the Elderly
No Results Yet
NCT05279170 | RECRUITING | NA
72 Participants

MAsk VEntilation With Paratracheal Pressure In Children. Para Tracheal Compression to Prevent Gastric Insufflation in Children

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-06
Completion: 2027-06-30
Conditions
Surgery Anesthesia Intubation Complication
Interventions
OTHER
No Results Yet
NCT05278741 | ACTIVE_NOT_RECRUITING | NA
32 Participants

Functional Evaluation After Breast Reconstruction With a Minimally Invasive Latissimus Dorsi Flap Following Radical Surgery for Breast Cancer.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-11-25
Completion: 2026-03-06
Conditions
Breast Cancer
Interventions
PROCEDURE
No Results Yet
NCT05274022 | ACTIVE_NOT_RECRUITING | NA
66 Participants

Rehabilitation Strategies to Improve Outcomes For Patients With a Lower Extremity Fracture

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-03-03
Completion: 2026-02-01
Conditions
Femoral Fracture Tibial Fractures
Interventions
OTHER
No Results Yet
NCT05273138 | RECRUITING
40 Participants

Analysis of Dermal Fibroblasts and Immune Cells During Systemic Sclerosis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-06-08
Completion: 2026-06-30
Conditions
Systemic Sclerosis
Interventions
OTHER
No Results Yet
NCT05273125 | RECRUITING
417 Participants

MOBility Disorders Assessment in Patients With Mild COGnitive Disorders

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-09-09
Completion: 2026-09-30
Conditions
Cognitive Dysfunction
Interventions
BEHAVIORAL
No Results Yet
NCT05256225 | RECRUITING | PHASE3
360 Participants

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-11-16
Completion: 2027-10-31
Conditions
Endometrial Carcinoma Endometrial Clear Cell Adenocarcinoma Endometrial Dedifferentiated Carcinoma Endometrial Endometrioid Adenocarcinoma Endometrial Mixed Cell Adenocarcinoma Endometrial Serous Adenocarcinoma Endometrial Undifferentiated Carcinoma Uterine Corpus Carcinosarcoma
Interventions
PROCEDURE DRUG RADIATION OTHER
No Results Yet
NCT05233449 | COMPLETED | NA
30 Participants

NoL Index Response to Stimulation in Anesthetized Children

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-03-04
Completion: 2022-05-17
Conditions
Anesthesia
Interventions
DEVICE PROCEDURE
No Results Yet
NCT05230914 | RECRUITING | NA
1846 Participants

A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-12-12
Completion: 2027-06-30
Conditions
Stroke, Ischemic Stroke, Acute
Interventions
OTHER
No Results Yet
NCT05223036 | SUSPENDED | PHASE2
80 Participants

Testing Obeticholic Acid for Familial Adenomatous Polyposis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-01-19
Completion: 2029-01-31
Conditions
Attenuated Familial Adenomatous Polyposis Colorectal Carcinoma Duodenal Carcinoma Familial Adenomatous Polyposis
Interventions
PROCEDURE BIOLOGICAL DRUG OTHER
No Results Yet
NCT05198830 | RECRUITING | PHASE2
42 Participants

Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-12-15
Completion: 2027-06-30
Conditions
Lung Adenocarcinoma Lung Large Cell Carcinoma Lung Non-Squamous Non-Small Cell Carcinoma Stage III Lung Cancer AJCC v8
Interventions
DRUG PROCEDURE BIOLOGICAL RADIATION
No Results Yet
NCT05183048 | RECRUITING | EARLY_PHASE1
14 Participants

Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-02-20
Completion: 2028-02-29
Conditions
Head and Neck Squamous Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT05161689 | COMPLETED | NA
636 Participants

Addressing the Continuum of Care Among High-risk Thai Men

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-11-27
Completion: 2024-12-10
Conditions
HIV/AIDS STD
Interventions
BEHAVIORAL
Results Available
NCT05144724 | COMPLETED | NA
52 Participants

Volume Targeted Mask Ventilation Versus Pressure Ventilation in Preterm Infants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-10-01
Completion: 2025-10-30
Conditions
Neonatal Respiratory Distress
Interventions
PROCEDURE
No Results Yet
NCT05142293 | ACTIVE_NOT_RECRUITING
354 Participants

One Day Implantation Program for Heart Failure Patients Implanted With CRT-P

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-12-06
Completion: 2026-01-31
Conditions
Heart Failure
Interventions
OTHER
No Results Yet
NCT05136664 | COMPLETED | PHASE3
262 Participants

Trial Evaluating the Efficacy and Safety of Patiromer in Chinese Subjects

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-02-10
Completion: 2025-11-18
Conditions
Hyperkalemia Renal Insufficiency, Chronic
Interventions
DRUG
No Results Yet
NCT05136196 | RECRUITING | PHASE2
150 Participants

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-12-06
Completion: 2027-01-01
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 Locally Recurrent Head and Neck Squamous Cell Carcinoma Locally Recurrent Hypopharyngeal Squamous Cell Carcinoma Locally Recurrent Laryngeal Squamous Cell Carcinoma Locally Recurrent Oral Cavity Squamous Cell Carcinoma Locally Recurrent Oropharyngeal Squamous Cell Carcinoma Metastatic Head and Neck Squamous Cell Carcinoma Metastatic Hypopharyngeal Squamous Cell Carcinoma Metastatic Laryngeal Squamous Cell Carcinoma Metastatic Melanoma Metastatic Oral Cavity Squamous Cell Carcinoma Metastatic Oropharyngeal Squamous Cell Carcinoma Recurrent Melanoma Stage III Hypopharyngeal Carcinoma AJCC v8 Stage III Laryngeal Cancer AJCC v8 Stage III Lip and Oral Cavity Cancer AJCC v8 Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage IV Hypopharyngeal Carcinoma AJCC v8 Stage IV Laryngeal Cancer AJCC v8 Stage IV Lip and Oral Cavity Cancer AJCC v8 Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Unresectable Melanoma
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT05112601 | RECRUITING | PHASE2
81 Participants

Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-06-02
Completion: 2026-04-30
Conditions
Endometrial Adenocarcinoma Endometrial Clear Cell Adenocarcinoma Endometrial Dedifferentiated Carcinoma Endometrial Endometrioid Adenocarcinoma Endometrial Mixed Cell Adenocarcinoma Endometrial Mucinous Adenocarcinoma Endometrial Undifferentiated Carcinoma Endometrioid Adenocarcinoma Recurrent Endometrial Carcinoma
Interventions
PROCEDURE BIOLOGICAL
No Results Yet
NCT05111574 | RECRUITING | PHASE2
99 Participants

Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-08-11
Completion: 2025-12-19
Conditions
Anal Melanoma Bladder Melanoma Cervical Melanoma Esophageal Melanoma Gallbladder Melanoma Head and Neck Mucosal Melanoma Mucosal Melanoma Nasopharyngeal Mucosal Melanoma Oral Cavity Mucosal Melanoma Penile Mucosal Melanoma Rectal Melanoma Recurrent Mucosal Melanoma Sinonasal Mucosal Melanoma Urethral Melanoma Urinary System Mucosal Melanoma Vaginal Melanoma Vulvar Melanoma
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
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