A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)
NCT ID: NCT05230914
Last Updated: 2024-12-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
NOT_YET_RECRUITING
NA
1846 participants
INTERVENTIONAL
2025-01-01
2027-06-01
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The newly published MR CLEAN-LATE and TENSION trials used NCCT or CTA, but still relied on ASPECTS scores to evaluate and select patients for endovascular therapy. However, different trials have different time windows. The aim of this trial was to assess the clinical outcomes of stroke patients with anterior large vessel occlusion who selected by simple imaging (NCCT) comparing via standard imaging screening strategy (CTP/MRI). The hypothesis is that simple imaging is non-inferior to standard imaging selection strategy in terms of achieving favorable outcomes.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Keywords
Explore important study keywords that can help with search, categorization, and topic discovery.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Simple imaging
NCCT and CTA will be used to screen patients for endovascular treatment
Simplified imaging strategy
NCCT and CTA will be used to screen patients for endovascular treatment
Standard imaging
NCCT-ASPECTS (pc-ASPECTS), CTA, and CTP will be used to screen patients for endovascular treatment
Standard imaging strategy
NCCT-ASPECTS (pc-ASPECTS), CTA, and CTP will be used to screen patients for endovascular treatment
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Simplified imaging strategy
NCCT and CTA will be used to screen patients for endovascular treatment
Standard imaging strategy
NCCT-ASPECTS (pc-ASPECTS), CTA, and CTP will be used to screen patients for endovascular treatment
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. The interval time from last known well to hospital arrival is within 24 hours;
3. Acute stroke confirmed by clinical symptoms or imaging examination;
4. Field Assessment Stroke Triage for Emergency Destination (FAST ED) ≥4;
5. Written informed consent is obtained from patients and/or their legal representatives.
Exclusion Criteria
2. Currently pregnant or lactating (women patients);
3. Arterial tortuosity and/or other arterial disease that would prevent the device from reaching the target vessel;
4. Preexisting neurological or psychiatric disease that would confound the neurological functional evaluations;
5. Multiple vessel occlusion (e.g., bilateral anterior circulation, or occlusion of both anterior and posterior circulation);
6. Brain tumors with mass effect (except meningiomas) that are radiographically pleasant;
7. Intracranial aneurysm, arteriovenous malformation;
8. Any terminal illness with life expectancy less than 6 months;
9. Unlikely to be available for 90-day follow-up.
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
The First Affiliated Hospital of Hainan Medical University
OTHER_GOV
Dalian Central Hospital
UNKNOWN
Huai'an First People's Hospital
OTHER
Xinqiao Hospital of Chongqing
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Zhongming Qiu
Professor
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Yijishan Hospital of Wannan Medical College
Wuhu, Anhui, China
Xinqiao Hospital of Army Medical University
Chongqing, Chongqing Municipality, China
Wuyi Traditional Chinese Medicine Hospital
Jiangmen, Guangdong, China
Jiangmen Central Hospital
Jiangmen, Guangdong, China
Maoming Traditional Chinese Medicine Hospital
Maoming, Guangdong, China
The 924th Hospital of CPLA
Guilin, Guangxi, China
The First Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China
Wuhan No. 1 Hospital
Wuhan, Hubei, China
Huai'an First People's Hospital
Huai'an, Jiangsu, China
The 904th Hospital of CPLA
Wuxi, Jiangsu, China
Xuzhou Central Hospital
Xuzhou, Jiangsu, China
Jingdezhen First People's Hospital
Jingdezhen, Jiangxi, China
The First Affiliated Hospital of Jilin University
Changchun, Jilin, China
Dalian Central Hospital
Dalian, Liaoning, China
The Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan, China
Countries
Review the countries where the study has at least one active or historical site.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Zhenqiang Zhao, MD
Role: primary
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
NO-SELECT
Identifier Type: -
Identifier Source: org_study_id