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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06968195 | SUSPENDED | PHASE1
24 Participants

Autologous CAR T Cells Targeting GPC3 (RPCAR01) for the Treatment of Advanced or Metastatic GPC3 Expressing Hepatocellular Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2026-01-30
Completion: 2028-05-30
Conditions
Advanced Hepatocellular Carcinoma Metastatic Hepatocellular Carcinoma Recurrent Hepatocellular Carcinoma Refractory Hepatocellular Carcinoma Stage III Hepatocellular Carcinoma AJCC v8 Stage IV Hepatocellular Carcinoma AJCC v8
Interventions
BIOLOGICAL PROCEDURE DRUG
No Results Yet
NCT06966323 | RECRUITING
150 Participants

Hold me Tight/Let me Go: Effectiveness of a Course to Enhance Parent-adolescent Relationship

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2025-06-11
Completion: 2028-02-01
Conditions
Parent Training Parent Child Relationship Parent-child Problem
Interventions
BEHAVIORAL
No Results Yet
NCT06962280 | RECRUITING | PHASE3
465 Participants

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-05-12
Completion: 2027-04-30
Conditions
Type 1 Diabetes Obesity Overweight
Interventions
DRUG
No Results Yet
NCT06952530 | RECRUITING | PHASE3
487 Participants

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-30
Completion: 2027-09-30
Conditions
Hypertension
Interventions
DRUG
No Results Yet
NCT06948435 | RECRUITING | PHASE3
487 Participants

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-30
Completion: 2027-09-30
Conditions
Hypertension Overweight or Obesity
Interventions
DRUG
No Results Yet
NCT06945419 | RECRUITING | PHASE1
201 Participants

A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-23
Completion: 2026-04-30
Conditions
Healthy Overweight Obesity Type 2 Diabetes
Interventions
DRUG
No Results Yet
NCT06944028 | RECRUITING | NA
666 Participants

Evaluation of Selective and Stepwise Excavation in Young Permanent Teeth With Deep Caries Lesions.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-09-01
Completion: 2028-09-01
Conditions
Dental Caries Dental Cavities
Interventions
PROCEDURE
No Results Yet
NCT06942832 | COMPLETED | NA
142 Participants

Integrating SPOZ Technology to Support and Enhance the Vitality Acupunch (VA) Exercise Program for Older Adults With Dementia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-24
Completion: 2025-12-18
Conditions
Disease and Dysfunction Functional Fitness Deterioration Activities of Daily Living Instrumental Activities of Daily Living Sleep Quality
Interventions
OTHER
No Results Yet
NCT06942637 | ACTIVE_NOT_RECRUITING | NA
680 Participants

Effectiveness of Integrated Network for Student Psychosocial Intervention, Resilience, and Education (INSPIRE) on Mental Health Outcomes Among Indonesian Adolescents in Bandung

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-28
Completion: 2026-02-16
Conditions
Adolescents Health Knowledge Mental Health Health Literacy Resilience Depression Anxiety Parents School Intervention
Interventions
BEHAVIORAL
No Results Yet
NCT06941597 | COMPLETED
40 Participants

Comparison of Two Gait Re-training Modalities During a Cardiac Rehabilitation Stay: Benefit of Orienteering Walking

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-28
Completion: 2025-10-05
Conditions
Cardiovascular Diseases (CVD) Coronary Heart Disease (CHD) Heart Failure Congenital Heart Disease
No Results Yet
NCT06941506 | COMPLETED | NA
142 Participants

Using SPOZ Technology to Support and Enhance the Vitality Acupunch (VA) Exercise Program for Older Adults With Dementia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-23
Completion: 2025-12-18
Conditions
Cognitive and Behavioral Impairment Sensory and Perceptual Impairment
Interventions
OTHER
No Results Yet
NCT06939686 | RECRUITING | NA
30 Participants

Miro3D Wound Matrix Study for Diabetic Foot Ulcers and Wound Healing

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-11-01
Completion: 2026-07-31
Conditions
Diabetic Foot Ulcers (DFUs) Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer)
Interventions
DEVICE OTHER
No Results Yet
NCT06939673 | RECRUITING | NA
20 Participants

Study of Miro3D Wound Matrix for Healing Wounds and Ulcers in Outpatient Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-02-29
Completion: 2025-12-31
Conditions
Diabetic Foot Ulcers (DFUs) Venous Leg Ulcers (VLUs) Pressure Ulcers Surgical Wound Dehiscence (SWD) Chronic Wounds Undermined and Tunneling Wounds
Interventions
DEVICE
No Results Yet
NCT06939647 | AVAILABLE

An Expanded Access Study to Assess Treprostinil Palmitil Inhalation Powder (TPIP) for Participants With Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Study Type: EXPANDED_ACCESS
Last Updated: 2025-12-24
Conditions
Pulmonary Arterial Hypertension Pulmonary Hypertension, Interstitial Lung Disease
Interventions
DRUG
No Results Yet
NCT06921824 | COMPLETED | NA
16 Participants

Investigating the Acute Effects of Increasing Glucagon Exposure in Healthy Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-03-31
Completion: 2025-09-19
Conditions
Glucose Metabolism Glucagon
Interventions
OTHER
No Results Yet
NCT06920043 | RECRUITING | PHASE2
42 Participants

A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-09
Completion: 2027-11-30
Conditions
Metabolic Dysfunction-Associated Steatohepatitis
Interventions
DRUG
No Results Yet
NCT06917313 | RECRUITING | PHASE2
92 Participants

FLASH-Breast: Evaluating the Efficacy of Fezolinetant in Reducing Vasomotor Symptoms in Women With Breast Cancer on Endocrine Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-12-05
Completion: 2028-03-31
Conditions
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Interventions
DRUG
No Results Yet
NCT06916806 | RECRUITING | PHASE1
72 Participants

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-05-01
Completion: 2027-06-22
Conditions
Systemic Lupus Erythematosus Idiopathic Inflammatory Myopathies Rheumatoid Arthritis
Interventions
DRUG
No Results Yet
NCT06914895 | RECRUITING | PHASE3
905 Participants

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-25
Completion: 2027-05-31
Conditions
Type 1 Diabetes Obesity Overweight
Interventions
DRUG
No Results Yet
NCT06912633 | RECRUITING | PHASE2
60 Participants

Safety of a Single, Intravitreal Injection of 8.8M jCell (Famzeretcel) in Retinitis Pigmentosa (RP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-06-20
Completion: 2026-09-30
Conditions
Retinitis Pigmentosa
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT06909565 | RECRUITING | PHASE4
6000 Participants

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-07-23
Completion: 2029-10-31
Conditions
Percutaneous Coronary Intervention Peripheral Endovascular Intervention
Interventions
DRUG
No Results Yet
NCT06901544 | COMPLETED
100 Participants

Capillary Leak Index as a Prognostic Indicator for Post-Operative Abdominal Sepsis in Critically Ill Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2025-03-04
Completion: 2025-08-01
Conditions
Intra-Abdominal Infections Intestinal Obstruction Appendicitis Acute Perforated Viscus
Results Available
NCT06897475 | RECRUITING | PHASE2
240 Participants

A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-03-28
Completion: 2026-12-31
Conditions
Type 2 Diabetes
Interventions
DRUG
No Results Yet
NCT06881784 | RECRUITING | PHASE3
420 Participants

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-05-06
Completion: 2027-12-01
Conditions
NSCLC (Non-small Cell Lung Cancer) Non-Small Cell Lung Cancer NSCLC NSCLC (Non-small Cell Lung Carcinoma) NSCLC (Advanced Non-small Cell Lung Cancer)
Interventions
DRUG
No Results Yet
NCT06880055 | RECRUITING
3375 Participants

Shield Post-Approval Study Protocol

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2025-07-14
Completion: 2030-09-01
Conditions
Colo-rectal Cancer
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT06875115 | COMPLETED | NA
60 Participants

Evaluation of the Efficacy of Laser Acupuncture on Uremic Pruritus

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-04-09
Completion: 2024-05-11
Conditions
Uremia
Interventions
DEVICE
Results Available
NCT06871410 | RECRUITING | PHASE1
26 Participants

Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2026-01-15
Completion: 2028-04-01
Conditions
Recurrent Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia
Interventions
DRUG PROCEDURE OTHER
No Results Yet
NCT06865651 | RECRUITING | PHASE2
44 Participants

Study of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic Urticaria

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-05-22
Completion: 2027-09-01
Conditions
Chronic Urticaria (CU): Chronic Inducible Urticaria (CINDU) and Chronic Spontaneous Urticaria (CSU)
Interventions
DRUG
No Results Yet
NCT06864104 | ACTIVE_NOT_RECRUITING | PHASE2
206 Participants

A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-10
Completion: 2026-01-09
Conditions
Hypertension
Interventions
DRUG
No Results Yet
NCT06864026 | RECRUITING | PHASE4
200 Participants

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-03-06
Completion: 2027-11-30
Conditions
Psoriatic Arthritis Overweight or Obesity
Interventions
DRUG
No Results Yet
NCT06853860 | COMPLETED | NA
70 Participants

Effects of Hand Massage Applied With Two Different Methods

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-02-15
Completion: 2025-05-15
Conditions
Angiopathy, Peripheral Pain, Acute Reflexology
Interventions
OTHER
No Results Yet
NCT06853158 | RECRUITING | NA
90 Participants

MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-02
Completion: 2027-01-31
Conditions
Sickle Cell Disease
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT06851559 | RECRUITING | PHASE2
80 Participants

A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-10-30
Completion: 2026-12-31
Conditions
Eosinophilic Esophagitis
Interventions
DRUG
No Results Yet
NCT06849947 | NOT_YET_RECRUITING | PHASE2
272 Participants

Fulvestrant With Ribociclib Versus Physician's Choice Treatments Recurred After Completion of Adjuvant Cyclin-Dependent Kinase 4/6 Inhibitors in HR+, HER2- Metastatic Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2026-02-01
Completion: 2031-06-30
Conditions
Breast Cancer Metastatic
Interventions
DRUG
No Results Yet
NCT06848348 | RECRUITING | PHASE2
200 Participants

Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-02-21
Completion: 2026-07-31
Conditions
Chemotherapy Induced Neuropathic Pain
Interventions
DRUG
No Results Yet
NCT06847854 | RECRUITING | PHASE1
176 Participants

A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2022-12-08
Completion: 2027-02-28
Conditions
Diabetic Macular Edema
Interventions
DRUG
No Results Yet
NCT06844318 | RECRUITING
153 Participants

Impact of IBD Activity on Frailty in Patients Over 60 Years

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2025-04-14
Completion: 2026-04-30
Conditions
IBD
No Results Yet
NCT06843252 | RECRUITING | NA
16 Participants

Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-09-02
Completion: 2026-12-31
Conditions
Huntington Disease
Interventions
DEVICE
No Results Yet
NCT06841874 | NO_LONGER_AVAILABLE

Expanded Access Program of Taletrectinib in Patients With Advanced or Metastatic ROS1-Positive NSCLC

Study Type: EXPANDED_ACCESS
Last Updated: 2025-12-24
Conditions
Bronchogenic Carcinoma Lung Neoplasms Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Neoplasms Lung Diseases Respiratory Tract Diseases Carcinoma Non Small Cell Carcinoma of the Lung ROS1-positive Non-Small Cell Lung Cancer (NSCLC)
Interventions
DRUG
No Results Yet
NCT06839235 | RECRUITING | PHASE1/PHASE2
23 Participants

Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 (redePHine)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-06-16
Completion: 2029-03-31
Conditions
Primary Hyperoxaluria Type 1 (PH1)
Interventions
DRUG
No Results Yet
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