A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1

NCT ID: NCT06948435

Last Updated: 2025-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

487 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-30

Study Completion Date

2027-09-30

Brief Summary

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GZL1 is an independent study conducted under the GZPL master protocol. GZL1 will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight.

Detailed Description

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Conditions

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Hypertension Overweight or Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Orforglipron

Participants will receive orforglipron orally.

Group Type EXPERIMENTAL

Orforglipron

Intervention Type DRUG

Administered orally

Placebo

Administered placebo.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

placebo administered.

Interventions

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Orforglipron

Administered orally

Intervention Type DRUG

Placebo

placebo administered.

Intervention Type DRUG

Other Intervention Names

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LY3502970

Eligibility Criteria

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Inclusion Criteria

* refer to the GZPL master protocol for screening eligibility.

Exclusion Criteria

* refer to the GZPL master protocol for screening eligibility.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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Elite Clinical Studies, LLC

Phoenix, Arizona, United States

Site Status RECRUITING

Valley Clinical Trials, Inc.

Covina, California, United States

Site Status RECRUITING

Valley Clinical Trials, Inc.

Northridge, California, United States

Site Status RECRUITING

Chase Medical Research, LLC

Waterbury, Connecticut, United States

Site Status RECRUITING

Excel Medical Clinical Trials

Boca Raton, Florida, United States

Site Status RECRUITING

Care Access - Brandon

Brandon, Florida, United States

Site Status RECRUITING

Northeast Research Institute - Downtown Office

Jacksonville, Florida, United States

Site Status RECRUITING

Peace River Cardiovascular Center

Port Charlotte, Florida, United States

Site Status NOT_YET_RECRUITING

Care Access - St. Petersburg

St. Petersburg, Florida, United States

Site Status NOT_YET_RECRUITING

East-West Medical Research Institute

Honolulu, Hawaii, United States

Site Status RECRUITING

Sinai Hospital Of Baltimore

Baltimore, Maryland, United States

Site Status NOT_YET_RECRUITING

Ascension Saint Agnes Heart Care

Baltimore, Maryland, United States

Site Status RECRUITING

Lucida Clinical Trials

New Bedford, Massachusetts, United States

Site Status RECRUITING

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan, United States

Site Status RECRUITING

StudyMetrix Research

City of Saint Peters, Missouri, United States

Site Status RECRUITING

Excel Clinical Research, LLC

Las Vegas, Nevada, United States

Site Status RECRUITING

Palm Research Center Sunset

Las Vegas, Nevada, United States

Site Status RECRUITING

Rochester Clinical Research, LLC

Rochester, New York, United States

Site Status RECRUITING

Remington-Davis, Inc

Columbus, Ohio, United States

Site Status RECRUITING

PriMED Clinical Research

Dayton, Ohio, United States

Site Status RECRUITING

Advanced Research Institute - Tigard

Tigard, Oregon, United States

Site Status RECRUITING

Care Access - Mauldin

Mauldin, South Carolina, United States

Site Status RECRUITING

Dallas Heart and Vascular Consultants, PA

Duncanville, Texas, United States

Site Status RECRUITING

Texas Institute of Cardiology, PA

McKinney, Texas, United States

Site Status RECRUITING

North Hills Family Medicine/North Hills Medical Research

North Richland Hills, Texas, United States

Site Status RECRUITING

Advanced Research Institute

Ogden, Utah, United States

Site Status RECRUITING

Carient Heart & Vascular - Manassas

Manassas, Virginia, United States

Site Status RECRUITING

Health Research of Hampton Roads, Inc.

Newport News, Virginia, United States

Site Status RECRUITING

National Clinical Research, Inc

Richmond, Virginia, United States

Site Status RECRUITING

Eastside Research Associates

Redmond, Washington, United States

Site Status RECRUITING

Instituto Médico Especializado (IME)

Buenos Aires, , Argentina

Site Status RECRUITING

CIPREC

Buenos Aires, , Argentina

Site Status RECRUITING

CIPREC

Buenos Aires, , Argentina

Site Status RECRUITING

CEMEDIC

Buenos Aires, , Argentina

Site Status RECRUITING

Instituto de Investigaciones Clínicas Córdoba

Córdoba, , Argentina

Site Status RECRUITING

Centro de Investigaciones Clínicas Baigorria

Granadero Baigorria, , Argentina

Site Status RECRUITING

INECO Neurociencias Oroño

Rosario, , Argentina

Site Status RECRUITING

Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica

Rosario, , Argentina

Site Status RECRUITING

Santa Maria de la Salud Centro Medico

San Isidro, , Argentina

Site Status RECRUITING

Beijing Pinggu District Hospital

Beijing, , China

Site Status RECRUITING

China-Japan Union Hospital

Changchun, , China

Site Status RECRUITING

Changde First People's Hospital

Changde, , China

Site Status RECRUITING

Sichuan Provincial People's Hospital

Chengdu, , China

Site Status RECRUITING

The Second Affiliated Hospital of Chongqing Medical University - Yuzhong Campus

Chongqing, , China

Site Status RECRUITING

Jinan Central Hospital

Jinan, , China

Site Status RECRUITING

Lishui Central Hospital

Lishui, , China

Site Status RECRUITING

The First Affiliated Hospital of Henan University of Science &Technology

Luoyang Shi, , China

Site Status RECRUITING

Ruijin Hospital Shanghai Jiaotong University School of Medicine

Shanghai, , China

Site Status NOT_YET_RECRUITING

Siping Central People's Hospital

Siping, , China

Site Status RECRUITING

Wuxi People's Hospital

Wuxi, , China

Site Status RECRUITING

Shaanxi provincial people's hospital

Xi'an, , China

Site Status RECRUITING

Top Moravia Health

Brno, , Czechia

Site Status RECRUITING

Ordinace Rihackovi, s.r.o.

Brno, , Czechia

Site Status RECRUITING

CTC Hodonin s.r.o.

Hodonín, , Czechia

Site Status RECRUITING

MUDr. Sarka Drinkova

Ledeč nad Sázavou, , Czechia

Site Status RECRUITING

CCR Ostrava s.r.o

Ostrava, , Czechia

Site Status RECRUITING

Diahelp s.r.o

Pardubice V, , Czechia

Site Status RECRUITING

Clinoxus

Prague, , Czechia

Site Status RECRUITING

Angiocentrum Komorany

Prague, , Czechia

Site Status RECRUITING

Praglandia s.r.o

Prague, , Czechia

Site Status RECRUITING

Zentrum für klinische Studien Bad Homburg

Bad Homburg, , Germany

Site Status RECRUITING

FutureMeds GmbH

Berlin, , Germany

Site Status RECRUITING

Zentrum fur klinische Forschung - Köln

Cologne, , Germany

Site Status RECRUITING

Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien

Dresden, , Germany

Site Status RECRUITING

Universitaetsklinikum Carl Gustav Carus Dresden

Dresden, , Germany

Site Status RECRUITING

Medizentrum Essen Borbeck

Essen, , Germany

Site Status RECRUITING

AmBeNet GmbH

Leipzig, , Germany

Site Status RECRUITING

Familienmedizinisches Zentrum Radowsky

Leipzig, , Germany

Site Status RECRUITING

RED-Institut GmbH

Oldenburg, , Germany

Site Status RECRUITING

Athens Medical Center - Psychikon branch

Athens, , Greece

Site Status RECRUITING

General Hospital of Athens "G. Gennimatas"

Athens, , Greece

Site Status NOT_YET_RECRUITING

University Hospital of Ioannina

Ioannina, , Greece

Site Status RECRUITING

G. Gennimatas General Hospital of Thessaloniki

Thessaloniki, , Greece

Site Status RECRUITING

AHEPA University General Hospital of Thessaloniki

Thessaloniki, , Greece

Site Status RECRUITING

Papageorgiou General Hospital of Thessaloniki

Thessaloniki, , Greece

Site Status RECRUITING

Life Care Hospital and Research Centre

Bangalore, , India

Site Status NOT_YET_RECRUITING

All India Institute of Medical Sciences

Bhubaneswar, , India

Site Status NOT_YET_RECRUITING

G.B. Pant Institute of Postgraduate Medical Education & Research

New Delhi, , India

Site Status NOT_YET_RECRUITING

Ashirwad Hospital and Research Centre

Ulhasnagar, , India

Site Status NOT_YET_RECRUITING

Tokyo-Eki Center-building Clinic

Chūōku, , Japan

Site Status RECRUITING

Fukuwa Clinic

Chūōku, , Japan

Site Status RECRUITING

Takai Internal Medicine Clinic

Kamakura-shi, , Japan

Site Status RECRUITING

Mikannohana Clinic, Diabetes, Endocrinology and Metabolism

Matsuyama, , Japan

Site Status RECRUITING

Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic

Yamato-shi, , Japan

Site Status RECRUITING

Uniwersytecki Szpital Kliniczny w Białymstoku

Bialystok, , Poland

Site Status RECRUITING

Centrum Medyczne "Hipokrates" S.C. Elżbieta I Grzegorz Grześk

Bydgoszcz, , Poland

Site Status RECRUITING

NZOZ Centrum Medyczne KERmed

Bydgoszcz, , Poland

Site Status RECRUITING

IRMED

Piotrkow Trybunalski, , Poland

Site Status RECRUITING

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu

Przemyśl, , Poland

Site Status RECRUITING

Private Practice - Dr. Robert Witek

Tarnów, , Poland

Site Status RECRUITING

Balsam Medica

Warsaw, , Poland

Site Status RECRUITING

NZOZ Regionalna Poradnia Diabetologiczna

Wroclaw, , Poland

Site Status RECRUITING

Dorado Medical Complex

Dorado, , Puerto Rico

Site Status RECRUITING

Puerto Rico Medical Research

Ponce, , Puerto Rico

Site Status RECRUITING

CHUAC-Complejo Hospitalario Universitario A Coruña

A Coruña, , Spain

Site Status RECRUITING

Hospital San Rafael - La Coruña

A Coruña, , Spain

Site Status RECRUITING

EAP Sardenya

Barcelona, , Spain

Site Status RECRUITING

EAP Osona Sud - Alt Congost S.L.P

Centelles, , Spain

Site Status RECRUITING

Complejo Asistencial Universitario de León - Hospital de León

León, , Spain

Site Status RECRUITING

Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

Seville, , Spain

Site Status RECRUITING

Hospital Quiron Infanta Luisa

Seville, , Spain

Site Status RECRUITING

Countries

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United States Argentina China Czechia Germany Greece India Japan Poland Puerto Rico Spain

Central Contacts

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Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

Role: CONTACT

Phone: 1-317-615-4559

Email: [email protected]

Physicians interested in becoming principal investigators please contact

Role: CONTACT

Email: [email protected]

Facility Contacts

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Role: primary

Role: primary

Role: primary

Role: primary

Role: primary

Other Identifiers

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J2A-MC-GZL1

Identifier Type: OTHER

Identifier Source: secondary_id

J2A-MC-GZPL

Identifier Type: OTHER

Identifier Source: secondary_id

27359

Identifier Type: -

Identifier Source: org_study_id