Clinical Trials Updated in 2025

NCT04994756 | RECRUITING

40000 Participants

Stroke Thrombectomy and Aneurysm Registry

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2019-09-17

Completion: 2055-01-01

Conditions

Stroke Thromboses, Intracranial Aneurysm, Brain

Interventions

PROCEDURE

No Results Yet

NCT04982393 | ACTIVE_NOT_RECRUITING

207 Participants

BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2021-12-13

Completion: 2028-09-01

Conditions

Primary Hyperoxaluria Type 1

No Results Yet

NCT04968340 | COMPLETED | NA

600 Participants

External Pop Out cs vs Conventional Method for Fetal Head Extraction in Repeatedcaesarean Section.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-06-16

Completion: 2022-07-24

Conditions

EPO Teqnique in Fetal Head Extraction

Interventions

PROCEDURE

No Results Yet

NCT04961697 | COMPLETED | NA

431 Participants

Family and Patient Outcomes After Pediatric Intensive Care (FOREVER)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2019-12-20

Completion: 2021-12-16

Conditions

Post-Intensive Care Syndrome Anxiety Depression Stress Disorders, Post-Traumatic Quality of Life Satisfaction, Patient

Interventions

BEHAVIORAL

No Results Yet

NCT04948463 | COMPLETED | PHASE4

55 Participants

Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-11-15

Completion: 2025-12-17

Conditions

Febrile Neutropenia

Interventions

DRUG

No Results Yet

NCT04946201 | SUSPENDED

60 Participants

Premolar Extractions for Obstructive Sleep Apnea in Children With Overjet

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2021-09-02

Completion: 2026-12-31

Conditions

Malocclusion Obstructive Sleep Apnea

No Results Yet

NCT04939454 | COMPLETED | NA

22 Participants

Involvement of Skeletal Muscle Fibrocytes in sarcOpenia in Patients With Chronic ObstRuctive Pulmonary Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-11-29

Completion: 2025-11-21

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

PROCEDURE

No Results Yet

NCT04922814 | COMPLETED | NA

40 Participants

Comparison for the Effect of Neuromuscular Blocking Agents Versus Sedation Alone on Severe ARDS Patients Due to COVID-19

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-08-01

Completion: 2022-03-01

Conditions

COVID-19 Acute Respiratory Distress Syndrome Sedation Complication ICU Acquired Weakness

Interventions

DRUG

No Results Yet

NCT04916340 | RECRUITING | NA

240 Participants

Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 3

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-01-24

Completion: 2026-02-28

Conditions

Peripheral Vascular Diseases

Interventions

BEHAVIORAL

No Results Yet

NCT04916132 | RECRUITING

300 Participants

Diabetic Nephropathy in People With Diabetes. Prevalence and Predictive Factors

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2021-08-10

Completion: 2043-12-31

Conditions

Chronic Kidney Diseases Albuminuria Diabetic Kidney Disease Diabetic Nephropathies Diabetes type2 Molecular Sequence Variation Kidney Biopsy

Interventions

PROCEDURE

No Results Yet

NCT04915248 | RECRUITING | PHASE2

28 Participants

Study to Evaluate Combined Treatment of Daratumumab, Bortezomib and Dexamethasone in PBL Patients.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-07-11

Completion: 2026-01-01

Conditions

Plasmablastic Lymphoma

Interventions

DRUG

No Results Yet

NCT04913285 | ACTIVE_NOT_RECRUITING | PHASE1

400 Participants

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-08-04

Completion: 2028-11-30

Conditions

Solid Tumor, Adult Non-small Cell Lung Cancer Melanoma

Interventions

DRUG

No Results Yet

NCT04910568 | ACTIVE_NOT_RECRUITING | PHASE1

126 Participants

A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-07-26

Completion: 2029-12-10

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT04907825 | ACTIVE_NOT_RECRUITING | PHASE4

400 Participants

A Trial of Pharmacist Management of Oral Anticoagulation THerapy Versus Enhanced Usual CARe in the communitY for AF

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-03-13

Completion: 2025-08-31

Conditions

Atrial Fibrillation Stroke

Interventions

DRUG

No Results Yet

NCT04899310 | RECRUITING | PHASE1/PHASE2

74 Participants

A Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of mRNA-3705 in Participants With Isolated Methylmalonic Acidemia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-08-06

Completion: 2028-07-01

Conditions

Methylmalonic Acidemia

Interventions

BIOLOGICAL

No Results Yet

NCT04895306 | ACTIVE_NOT_RECRUITING | PHASE2

40 Participants

Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-11-15

Completion: 2026-04-30

Conditions

Pain Opioid Use Androgen Deficiency Back Pain

Interventions

DRUG

No Results Yet

NCT04888169 | COMPLETED | NA

1314 Participants

Studying the Modification of Attention Bias Remotely After Trauma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-04-20

Completion: 2025-06-30

Conditions

Post Traumatic Stress Disorder

Interventions

DEVICE

No Results Yet

NCT04867395 | RECRUITING | NA

282 Participants

A Multi-Phase Study Examining Hospital to Home Transitions for Children With Medical Complexity

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-07-23

Completion: 2027-03-31

Conditions

Children With Medical Complexity (CMC)

Interventions

BEHAVIORAL

No Results Yet

NCT04848506 | ENROLLING_BY_INVITATION | PHASE2/PHASE3

900 Participants

Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-05-06

Completion: 2028-03-31

Conditions

Symptomatic Hypertrophic Cardiomyopathy (HCM)

Interventions

DRUG

No Results Yet

NCT04847466 | ACTIVE_NOT_RECRUITING | PHASE2

18 Participants

Immunotherapy Combination: Irradiated PD-L1 CAR-NK Cells Plus Pembrolizumab Plus N-803 for Subjects With Recurrent/Metastatic Gastric or Head and Neck Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-12-14

Completion: 2027-01-31

Conditions

Gastroesophageal Junction (GEJ) Cancers Advanced HNSCC

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT04844866 | ACTIVE_NOT_RECRUITING | PHASE2

45 Participants

Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-08-18

Completion: 2025-01-15

Conditions

Diffuse Large B-cell Lymphoma

Interventions

GENETIC

No Results Yet

NCT04844606 | RECRUITING | PHASE3

150 Participants

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-05-26

Completion: 2030-12-31

Conditions

Ulcerative Colitis Ulcerative Colitis Chronic Inflammatory Bowel Diseases Crohn's Disease

Interventions

DRUG

No Results Yet

NCT04840472 | SUSPENDED | PHASE1

28 Participants

Study Evaluating 111In-Panitumumab for Nodal Staging in Head and Neck Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-03-30

Completion: 2027-03-31

Conditions

Head and Neck Cancer

Interventions

DRUG PROCEDURE

No Results Yet

NCT04838444 | ACTIVE_NOT_RECRUITING | PHASE3

363 Participants

Antibody Persistence And Long Term Safety Of A Chikungunya Virus Vaccine (VLA1553)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-04-02

Completion: 2025-12-31

Conditions

Chikungunya Virus Infection

Interventions

BIOLOGICAL

No Results Yet

NCT04837222 | ACTIVE_NOT_RECRUITING

1000 Participants

A Study of Brentuximab Vedotin in Adults With CD30-positive Lymphoma

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2021-06-07

Completion: 2026-06-19

Conditions

Lymphoma

Interventions

OTHER

No Results Yet

NCT04821310 | COMPLETED | PHASE2

43 Participants

Protonix Treatment of Maintenance of Healing in Pediatric Participants Aged 1-11 Years and 12-17 Years

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-01-13

Completion: 2025-12-16

Conditions

Esophagitis

Interventions

DRUG

No Results Yet

NCT04813042 | ACTIVE_NOT_RECRUITING | NA

293 Participants

Determining the Effectiveness of Working Out Dads to Reduce Mental Health Difficulties in Fathers of Young Children

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-06-24

Completion: 2024-05-31

Conditions

Mental Health Issue

Interventions

BEHAVIORAL

No Results Yet

NCT04804787 | COMPLETED | NA

101 Participants

Emotions in Multiple Sclerosis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-06-23

Completion: 2025-02-25

Conditions

Multiple Sclerosis

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04796012 | RECRUITING | PHASE1/PHASE2

23 Participants

VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-04-18

Completion: 2027-01-31

Conditions

Solid Tumor Rhabdomyosarcoma

Interventions

DRUG

No Results Yet

NCT04786574 | WITHDRAWN | PHASE3

0 Participants

A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-07-01

Completion: 2025-12-10

Conditions

Autosomal Recessive Polycystic Kidney Disease (ARPKD)

Interventions

DRUG

No Results Yet

NCT04779554 | RECRUITING | PHASE2

100 Participants

Flat Dose vs. Weight-based IP Chemotherapy for CRS/HIPEC

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-06-04

Completion: 2026-02-28

Conditions

Peritoneal Carcinomatosis

Interventions

DRUG

No Results Yet

NCT04769167 | COMPLETED | NA

114 Participants

Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and Diabetes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-02-01

Completion: 2023-12-05

Conditions

Congenital Heart Disease Viremia Virus Diseases Enterovirus Enterovirus Infections Heart Defects, Congenital Heart Diseases Prenatal Infection Diabetes Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus Pregnancy in Diabetic Pregnancy Complications Prenatal

Interventions

OTHER

No Results Yet

NCT04750928 | RECRUITING | PHASE1/PHASE2

55 Participants

Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-11-29

Completion: 2028-12-31

Conditions

Neurofibromatosis 1

Interventions

DRUG

No Results Yet

NCT04740567 | COMPLETED | NA

283 Participants

Early Cognitive Intervention in Delirium

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-02-09

Completion: 2024-11-14

Conditions

Delirium Cognitive Decline Dementia

Interventions

BEHAVIORAL

Results Available

NCT04728893 | RECRUITING | PHASE2

490 Participants

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-04-05

Completion: 2029-01-04

Conditions

Hematologic Malignancies Waldenstroms Macroglobulinaemia Non-Hodgkins Lymphoma Chronic Lymphocytic Leukaemia

Interventions

DRUG

No Results Yet

NCT04713449 | COMPLETED | NA

643 Participants

Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survival Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-01-19

Completion: 2025-01-31

Conditions

Oral Cancer Oropharyngeal Cancer Head and Neck Cancer

Interventions

OTHER

No Results Yet

NCT04704674 | ACTIVE_NOT_RECRUITING

396 Participants

Community Dynamics of Malaria Transmission in Humans and Mosquitoes in Fleh-la and Marshansue, Salala District, Bong County, Liberia

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2021-09-30

Completion: 2026-02-28

Conditions

Malaria

No Results Yet

NCT04699136 | COMPLETED | NA

60 Participants

Cardiovascular Rehabilitation and Reeducation (CVRR) in Patients With Cardiac Pathologies and the 6-minute Stepper Test

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-01-13

Completion: 2022-04-28

Conditions

Cardiac Disease

Interventions

OTHER

No Results Yet

NCT04696835 | RECRUITING | NA

40 Participants

fNIRS in Pediatric Hearing Aids

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-09-09

Completion: 2027-09-30

Conditions

Hearing Loss

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04682769 | COMPLETED

175 Participants

Cardiac Markers in Depressed Patients With Coronary Heart Disease - R01HL147862

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2020-12-01

Completion: 2025-01-25

Conditions

Coronary Heart Disease Depression

Interventions

OTHER

No Results Yet