Clinical Trials Updated in 2025

NCT06685640 | RECRUITING | NA

10 Participants

Comparison of Clinical Success of Stainless Steel Crowns and Zirconia Crowns in Primary Molars

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-07-30

Completion: 2026-08-30

Conditions

Dental Caries Pulpotomy

Interventions

OTHER

No Results Yet

NCT06681272 | ACTIVE_NOT_RECRUITING

84 Participants

Prediction of Chronic Pain in Cardiac Surgery: Evaluation by Algocartography Predict-ALGOCARTE

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2024-11-27

Completion: 2025-11-27

Conditions

Sternotomy Closure,Open Heart Surgery Cardiac Surgery Chronic Pain Post-Procedural

Interventions

OTHER

No Results Yet

NCT06679140 | RECRUITING | PHASE3

2330 Participants

A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-12-08

Completion: 2026-12-06

Conditions

COVID-19 SARS-CoV-2 Infection

Interventions

DRUG

No Results Yet

NCT06667453 | RECRUITING | PHASE2

24 Participants

A Clinical Study of PGN-EDODM1 in People With Myotonic Dystrophy Type 1

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-12-10

Completion: 2026-08-31

Conditions

Myotonic Dystrophy 1

Interventions

DRUG OTHER

No Results Yet

NCT06661473 | ACTIVE_NOT_RECRUITING | NA

105 Participants

Interventional Study Exploring the Occurrence of Surgical Site Infections.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-10-03

Completion: 2025-12-31

Conditions

Total Knee Arthroplasty Total Hip Arthroplasty Revision Total Knee Arthroplasty Revision

Interventions

DEVICE

No Results Yet

NCT06659146 | RECRUITING | NA

60 Participants

Thermotherapy in Addition to SOC Palliative Radiotherapy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-10-14

Completion: 2028-03-01

Conditions

Head and Neck Squamous Cell Carcinoma Cutaneous Squamous Cell Carcinoma Breast Cancer Recurrent

Interventions

DEVICE

No Results Yet

NCT06654193 | RECRUITING | PHASE1/PHASE2

70 Participants

Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2026-01-31

Completion: 2028-01-01

Conditions

Acute Kidney Injury

Interventions

DRUG

No Results Yet

NCT06648434 | RECRUITING | PHASE1

51 Participants

MK2 Inhibitor in Combination With mFOLFIRINOX for Untreated Metastatic Pancreatic Ductal Adenocarcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-05-15

Completion: 2027-06-30

Conditions

Metastatic Pancreatic Ductal Adenocarcinoma Pancreatic Cancer Cancer of the Pancreas

Interventions

DRUG

No Results Yet

NCT06647979 | RECRUITING | PHASE1

10 Participants

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-12-01

Completion: 2028-12-31

Conditions

Sickle Cell Disease Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0) Beta-Thalassemia Transfusion Dependent Beta-Thalassaemia

Interventions

BIOLOGICAL DEVICE

No Results Yet

NCT06647953 | RECRUITING | PHASE3

110 Participants

Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-03-21

Completion: 2029-03-31

Conditions

Pleuropulmonary Blastoma

Interventions

PROCEDURE DRUG BIOLOGICAL OTHER

No Results Yet

NCT06644664 | ACTIVE_NOT_RECRUITING | NA

300 Participants

Nicotine and Tobacco Message Framing to Change Smoking Behavior in Diverse Groups of Young Adult Smokers

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-24

Completion: 2026-08-31

Conditions

Tobacco-Related Carcinoma

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT06627764 | RECRUITING | NA

400 Participants

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-06-30

Completion: 2028-07-31

Conditions

Substance Abuse Intimate Partner Violence (IPV) HIV Infections Depression Anxiety

Interventions

BEHAVIORAL

No Results Yet

NCT06627647 | RECRUITING | PHASE3

878 Participants

A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-11-27

Completion: 2029-05-10

Conditions

Non-squamous Non-small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT06627439 | COMPLETED | NA

160 Participants

A Web-Based Healthy Living Training for Promotores

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-13

Completion: 2025-07-31

Conditions

Obesity Prevention

Interventions

BEHAVIORAL

No Results Yet

NCT06625775 | RECRUITING | PHASE1

392 Participants

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-10-29

Completion: 2028-11-30

Conditions

Advanced Breast Cancer Solid Tumor, Adult Metastatic Breast Cancer HER2 Mutation-Related Tumors HER2-positive Metastatic Breast Cancer KRAS Mutant Metastatic Colorectal Cancer Metastatic Lung Cancer Metastatic Colorectal Cancer Advanced Lung Cancer HR-positive, HER2-negative Advanced Breast Cancer HER2-positive Advanced Breast Cancer

Interventions

DRUG

No Results Yet

NCT06620276 | RECRUITING | NA

30 Participants

ACT_for Alcohol Use Disorder and Depression

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-05-01

Completion: 2026-12-01

Conditions

Depression - Major Depressive Disorder Alcohol Use Disorder

Interventions

BEHAVIORAL DRUG

No Results Yet

NCT06613620 | COMPLETED | NA

46 Participants

Additional Effects of Surface Electromyographic Biofeedback on Post Facilitation Stretching and Strengthening in Lower Crossed Syndrome;A Randomized Control Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-07-18

Completion: 2025-06-02

Conditions

Lower Cross Syndrome

Interventions

OTHER

No Results Yet

NCT06609343 | RECRUITING | PHASE1/PHASE2

16 Participants

Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2026-02-02

Completion: 2026-11-30

Conditions

End Stage Renal Disease Fatigue

Interventions

DRUG

No Results Yet

NCT06588855 | RECRUITING | PHASE3

350 Participants

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-12-11

Completion: 2027-06-30

Conditions

Moderately to Severely Active Ulcerative Colitis

Interventions

DRUG

No Results Yet

NCT06588491 | ACTIVE_NOT_RECRUITING | PHASE2

25 Participants

KYSA-8: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Treatment Refractory Stiff Person Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-25

Completion: 2026-04-30

Conditions

Stiff-Person Syndrome SPS

Interventions

BIOLOGICAL

No Results Yet

NCT06586515 | RECRUITING | PHASE1

630 Participants

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-12

Completion: 2029-03-31

Conditions

Pancreatic Ductal Adenocarcinoma Non-small Cell Lung Cancer Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT06584916 | COMPLETED | PHASE3

376 Participants

A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-13

Completion: 2025-11-21

Conditions

Obesity Overweight

Interventions

DRUG

No Results Yet

NCT06581198 | RECRUITING | PHASE2

179 Participants

A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-04

Completion: 2028-02-14

Conditions

Lupus Erythematosus, Systemic Lupus Nephritis

Interventions

BIOLOGICAL

No Results Yet

NCT06576440 | COMPLETED | NA

24 Participants

Effects of Ghrelin Administration on Motivation

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-02

Completion: 2024-12-20

Conditions

Major Depressive Disorder

Interventions

DRUG

No Results Yet

NCT06572228 | RECRUITING | PHASE4

250 Participants

Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-08-26

Completion: 2026-12-31

Conditions

Asthma

Interventions

DRUG

No Results Yet

NCT06571994 | COMPLETED | NA

60 Participants

The Plastic Exposure Reduction Transforms Health Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-05

Completion: 2025-07-03

Conditions

Endocrine Disruptors Inflammation Cardiometabolic Risk Factors

Interventions

BEHAVIORAL

No Results Yet

NCT06568939 | RECRUITING | PHASE2

150 Participants

A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-01-20

Completion: 2028-02-29

Conditions

Non-Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT06568237 | RECRUITING | PHASE2

200 Participants

A Study to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy (MSA): A Safety and Efficacy Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-10-02

Completion: 2027-05-20

Conditions

Multiple System Atrophy

Interventions

DRUG

No Results Yet

NCT06540326 | RECRUITING | PHASE2

100 Participants

Clinical Study of Second-line Treatment in Advanced Colorectal Cancer With Chemotherapy With Bevacizumab or Cetuximab

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-11-12

Completion: 2026-04-15

Conditions

Colorectal Cancer Metastatic

Interventions

DRUG

No Results Yet

NCT06538038 | RECRUITING

538 Participants

Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-17

Completion: 2028-08-31

Conditions

Non Small Cell Lung Cancer Epidermal Growth Factor Receptor Gene Mutation Stage III Lung Cancer Stage IV Lung Cancer

Interventions

DRUG

No Results Yet

NCT06534892 | ACTIVE_NOT_RECRUITING | PHASE3

10212 Participants

An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-08-01

Completion: 2026-09-30

Conditions

Respiratory Syncytial Virus Infections

Interventions

BIOLOGICAL

No Results Yet

NCT06531824 | RECRUITING | PHASE3

11000 Participants

EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-08-13

Completion: 2028-08-30

Conditions

Kidney Disease, Chronic

Interventions

DRUG

No Results Yet

NCT06525623 | RECRUITING | NA

50 Participants

Initial Resuscitation for Acute Kidney Injury in Cirrhosis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-12

Completion: 2026-09-30

Conditions

Cirrhosis, Liver Acute Kidney Injury Hepatorenal Syndrome

Interventions

OTHER

No Results Yet

NCT06523608 | RECRUITING

600 Participants

Prediction of Decompensation and HCC Development in Advanced Chronic Liver Disease

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-01

Completion: 2027-09-30

Conditions

Liver Diseases Hepatocellular Carcinoma Hepatocarcinoma Advanced Chronic Liver Disease

Interventions

OTHER

No Results Yet

NCT06522204 | COMPLETED | NA

60 Participants

Comparing the Gastric Emptying Times of Underweight and Healthy-weight School-aged Children

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-07-30

Completion: 2025-12-15

Conditions

Preoperative Fasting

Interventions

DRUG

No Results Yet

NCT06520865 | COMPLETED

560 Participants

TIDE Project: Biomarker Discovery for Chronic Tinnitus Diagnosis

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2024-08-01

Completion: 2025-11-30

Conditions

Tinnitus

Interventions

OTHER

No Results Yet

NCT06513962 | RECRUITING | PHASE3

60 Participants

Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-02-27

Completion: 2029-10-30

Conditions

Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm

Interventions

OTHER PROCEDURE DRUG

No Results Yet

NCT06513208 | RECRUITING | PHASE4

140 Participants

Ketorolac Effects on Post-operative Pain and Lumbar Fusion

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2026-01-31

Completion: 2027-06-30

Conditions

Lumbar Spinal Fusion

Interventions

DRUG

No Results Yet

NCT06500273 | RECRUITING | PHASE2

250 Participants

Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-06-18

Completion: 2027-08-24

Conditions

Large B-cell Lymphoma

Interventions

GENETIC DRUG DEVICE

No Results Yet

NCT06493604 | COMPLETED | PHASE3

116 Participants

A Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-06-24

Completion: 2025-02-27

Conditions

Dry Eye Disease

Interventions

DRUG

No Results Yet