Clinical Trials Updated in 2025

NCT06445062 | RECRUITING | PHASE1/PHASE2

1130 Participants

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-05-24

Completion: 2027-05-15

Conditions

Colorectal Cancer CRC Pancreatic Ductal Adenocarcinoma PDAC Gastrointestinal Cancer Metastatic Pancreatic Ductal Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT06444087 | ACTIVE_NOT_RECRUITING

192 Participants

Patient's Perspective on the Evolution of Hidradenitis Suppurativa Burden After Secukinumab Initiation

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2024-06-17

Completion: 2027-06-30

Conditions

Hidradenitis Suppurativa

Interventions

OTHER

No Results Yet

NCT06435468 | RECRUITING | NA

400 Participants

Biocollection of Rare Pediatric-onset of Autoimmune and Autoinflammatory Diseases

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-02-26

Completion: 2035-02-27

Conditions

Systemic Lupus Autoimmune Diseases Autoinflammatory Disease Genetic Disease

Interventions

GENETIC OTHER

No Results Yet

NCT06430866 | RECRUITING | PHASE3

154 Participants

Pharmacokinetic Similarity Between ABP 234 and Keytruda® (Pembrolizumab)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-12

Completion: 2026-12-14

Conditions

Early-stage Non-squamous Non-small Cell Lung Cancer (NSCLC)

Interventions

DRUG

No Results Yet

NCT06420349 | TERMINATED | PHASE1

7 Participants

NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-05-31

Completion: 2025-08-12

Conditions

Advanced Cholangiocarcinoma Metastatic Cholangiocarcinoma Refractory Cholangiocarcinoma Stage III Hilar Cholangiocarcinoma AJCC v8 Stage III Intrahepatic Cholangiocarcinoma AJCC v8 Stage IV Hilar Cholangiocarcinoma AJCC v8 Stage IV Intrahepatic Cholangiocarcinoma AJCC v8

Interventions

PROCEDURE BIOLOGICAL

No Results Yet

NCT06417125 | COMPLETED | PHASE4

324 Participants

Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-05-22

Completion: 2025-09-22

Conditions

Behavior Problem

Interventions

DRUG

No Results Yet

NCT06414330 | COMPLETED | PHASE3

124 Participants

Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus HTK Solution Cardioplegia Solution in Cardiac Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-06-01

Completion: 2025-11-12

Conditions

Cardiac Ischemia

Interventions

BIOLOGICAL

No Results Yet

NCT06412666 | RECRUITING | PHASE2/PHASE3

55 Participants

A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-05-29

Completion: 2030-01-31

Conditions

Pediatric Symptomatic Obstructive Hypertrophic Cardiomyopathy

Interventions

DRUG

No Results Yet

NCT06408506 | COMPLETED | NA

20 Participants

In-patient Comparison of Immediately Loaded and Non-loaded Submerged and Transgingival Healed Implants Within 4 Months

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2017-09-28

Completion: 2025-10-29

Conditions

Jaw, Edentulous

Interventions

PROCEDURE

No Results Yet

NCT06389656 | COMPLETED | NA

17 Participants

Addressing Weight Bias Internalization to Improve Adolescent Weight Management Outcomes: Open Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-04-08

Completion: 2025-02-15

Conditions

Body Weight Weight Bias Weight Stigma Weight

Interventions

BEHAVIORAL

No Results Yet

NCT06377215 | RECRUITING | NA

121 Participants

Understanding Aided Speech Perception in Noise

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-11-16

Completion: 2028-03-01

Conditions

Hearing Impairment, Sensorineural Spatial Perception Aging Hearing Aids

Interventions

DEVICE

No Results Yet

NCT06375681 | RECRUITING | NA

1600 Participants

Effectiveness of Cognitive Training in Older and Younger Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-10-01

Completion: 2028-01-31

Conditions

Cognitive Change

Interventions

BEHAVIORAL

No Results Yet

NCT06368817 | RECRUITING | PHASE2

240 Participants

A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-10-22

Completion: 2033-11-04

Conditions

Basal Ganglia Germinoma Central Nervous System Germinoma Diabetes Insipidus Pineal Region Germinoma Suprasellar Germinoma Thalamic Germinoma

Interventions

RADIATION PROCEDURE DRUG OTHER

No Results Yet

NCT06368622 | RECRUITING

500 Participants

Evolve China PMCF Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2024-04-24

Completion: 2027-11-30

Conditions

Intracranial Aneurysm

Interventions

DEVICE

No Results Yet

NCT06368427 | COMPLETED

10 Participants

Change in Patient-repOrted Outcomes in COPD Patients Newly Initiated on TRIXEO AEROSPHERE in Real worlD

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2024-04-30

Completion: 2025-11-17

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Interventions

DRUG

No Results Yet

NCT06349512 | RECRUITING | NA

60 Participants

68Ga-FAPI-46 PET/CT for Predicting Histological Response in Triple-negative Breast Cancer (FAP-IT)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-10-14

Completion: 2032-11-30

Conditions

Triple Negative Breast Cancer

Interventions

PROCEDURE

No Results Yet

NCT06349057 | RECRUITING | PHASE4

120 Participants

The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-01-01

Completion: 2025-10-01

Conditions

Postoperative Recovery Length of Hospital Stay Postoperative Complications

Interventions

DRUG

No Results Yet

NCT06346392 | RECRUITING | PHASE3

572 Participants

AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-03-04

Completion: 2026-05-14

Conditions

Gastric Cancer Gastroesophageal Junction Cancer

Interventions

DRUG

No Results Yet

NCT06344104 | ACTIVE_NOT_RECRUITING | PHASE3

326 Participants

A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-04-08

Completion: 2025-11-24

Conditions

Uncontrolled Hypertension Resistant Hypertension

Interventions

DRUG

No Results Yet

NCT06342908 | RECRUITING | PHASE1

6 Participants

A Vaccine (Neoantigen-Targeted ppDC) for the Treatment of H3 G34-mutant Diffuse Hemispheric Glioma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-06-14

Completion: 2027-03-08

Conditions

Diffuse Hemispheric Glioma, H3 G34-Mutant

Interventions

PROCEDURE BIOLOGICAL DRUG

No Results Yet

NCT06341452 | RECRUITING | NA

130 Participants

Comparison of Individualized Sodium Management Versus Standard Treatment in Hemodialysis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-12-16

Completion: 2026-12-31

Conditions

End Stage Renal Disease

Interventions

DEVICE

No Results Yet

NCT06332144 | COMPLETED | NA

41 Participants

Predicting Language and Literacy Growth in Children With ASD Using Statistical Learning

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-01-13

Completion: 2025-08-31

Conditions

Autism Spectrum Disorder Language Development Literacy

Interventions

BEHAVIORAL

No Results Yet

NCT06331312 | RECRUITING | PHASE3

288 Participants

Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-06-28

Completion: 2028-08-22

Conditions

Polymyalgia Rheumatica

Interventions

BIOLOGICAL

No Results Yet

NCT06330064 | RECRUITING | PHASE2

520 Participants

A Study To Evaluate The Efficacy And Safety Of Ifinatamab Deruxtecan (I-DXd) In Subjects With Recurrent Or Metastatic Solid Tumors (IDeate-PanTumor02)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-04-10

Completion: 2028-07-25

Conditions

Recurrent or Metastatic Solid Tumors

Interventions

DRUG

No Results Yet

NCT06329375 | RECRUITING | NA

160 Participants

Food Insecurity Reduction & Strategy Team

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-10-07

Completion: 2026-03-31

Conditions

Diabetes Mellitus, Type 2 Food Insecurity Diabetes Mellitus, Type 1

Interventions

OTHER

No Results Yet

NCT06327074 | ACTIVE_NOT_RECRUITING | NA

40 Participants

Testing the Engaged Approach to Lung Cancer Screening

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-03-11

Completion: 2024-10-30

Conditions

Lung Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT06324357 | RECRUITING | PHASE1/PHASE2

768 Participants

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-06-03

Completion: 2029-01-08

Conditions

Metastatic Breast Cancer Metastatic Gastric Adenocarcinoma Gastroesophageal Junction Adenocarcinoma Esophageal Adenocarcinoma Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT06323109 | RECRUITING

80 Participants

US Imaging for the Assessment of LUTS

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2023-11-28

Completion: 2027-01-31

Conditions

Lower Urinary Tract Symptoms BPH

Interventions

DEVICE

No Results Yet

NCT06315556 | RECRUITING

200 Participants

An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a Paediatric Dosing Device is Used in Preterm Babies With Retinopathy of Prematurity in the United Kingdom (UK)

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2024-03-05

Completion: 2027-03-31

Conditions

Retinopathy of Prematurity Preterm Infants

Interventions

DRUG

No Results Yet

NCT06310005 | COMPLETED | PHASE1

36 Participants

A Study in Healthy Japanese Men to Test How Well Different Doses of BI 3006337 Are Tolerated

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-04-19

Completion: 2024-10-31

Conditions

Healthy

Interventions

DRUG

Results Available

NCT06306586 | RECRUITING | NA

60 Participants

A Digital Treatment for Adolescents With Eating Disorders

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-03-11

Completion: 2027-01-01

Conditions

Eating Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT06302439 | RECRUITING

1000 Participants

PROPEL - A Prospective Observational Patient Registry to Evaluate ENPP1 and ABCC6 Deficiency

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2024-07-25

Completion: 2034-05-31

Conditions

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Deficiency ATP-Binding Cassette Subfamily C Member 6 Deficiency

Interventions

OTHER

No Results Yet

NCT06296641 | SUSPENDED | NA

60 Participants

Needs Navigation for Caregivers of AYAs

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-02-16

Completion: 2026-07-31

Conditions

Cancer in Adolescence

Interventions

BEHAVIORAL

No Results Yet

NCT06270602 | RECRUITING

15000 Participants

The ONCOCAMP Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-22

Start Date: 2023-07-14

Completion: 2026-05-31

Conditions

Oncology

Interventions

OTHER

No Results Yet

NCT06266338 | RECRUITING | PHASE2

30 Participants

Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-03-11

Completion: 2026-10-31

Conditions

Cervix Cancer Cervical Cancer

Interventions

DRUG

No Results Yet

NCT06255353 | COMPLETED | NA

118 Participants

Effect of Different Feeding Modes in Intracerebral Hemorrhage

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-02-28

Completion: 2025-10-19

Conditions

Intracerebral Hemorrhage

Interventions

DEVICE BEHAVIORAL

No Results Yet

NCT06249984 | RECRUITING | NA

80 Participants

Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-12-20

Completion: 2027-03-01

Conditions

Tobacco-Related Carcinoma

Interventions

PROCEDURE BEHAVIORAL OTHER

No Results Yet

NCT06247189 | RECRUITING | NA

30 Participants

ICOPE Program Feasibility in the Management of Myeloma Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2025-12-03

Completion: 2026-12-03

Conditions

Frailty Multiple Myeloma

Interventions

OTHER

No Results Yet

NCT06246643 | ACTIVE_NOT_RECRUITING | PHASE2

13 Participants

A Study of Continued Treatment With Regorafenib in Participants With Solid Tumors Who Have Participated in Other Bayer Studies

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-01-24

Completion: 2028-04-27

Conditions

Solid Malignant Tumors

Interventions

DRUG

No Results Yet

NCT06244212 | RECRUITING | NA

30 Participants

Topical Treatment for Atopic Dermatitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-22

Start Date: 2024-09-19

Completion: 2026-07-31

Conditions

Atopic Dermatitis

Interventions

OTHER BEHAVIORAL

No Results Yet