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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05577754 | RECRUITING | PHASE2
20 Participants

Assessment of the Efficacy and Safety of Alpelisib (BYL719) in Pediatric and Adult Patients With Megalencephaly-CApillary Malformation Polymicrogyria Syndrome (MCAP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-28
Completion: 2027-03-31
Conditions
Megalencephaly-capillary Malformation Polymicrogyria Syndrome (MCAP)
Interventions
DRUG PROCEDURE
No Results Yet
NCT05572073 | RECRUITING
150 Participants

Otoferlin Gene-mediated Hearing Loss Natural History Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-07-14
Completion: 2029-02-28
Conditions
Sensorineural Hearing Loss, Bilateral
Interventions
OTHER
No Results Yet
NCT05570955 | ACTIVE_NOT_RECRUITING | NA
40 Participants

Deucravacitinib Adherence Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-07-24
Completion: 2026-03-31
Conditions
Psoriasis
Interventions
BEHAVIORAL
No Results Yet
NCT05570721 | RECRUITING | NA
30 Participants

Depression, Aging, Stress and Heart Health Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-16
Completion: 2026-06-30
Conditions
Menopause Depression Heart Disease in Women Stress
Interventions
BEHAVIORAL
No Results Yet
NCT05568160 | ACTIVE_NOT_RECRUITING | PHASE3
840 Participants

Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-01-02
Completion: 2026-03-31
Conditions
Scheduled Cardiac Surgery With Extracorporeal Circulation Vasoplegic Syndrome
Interventions
DRUG OTHER
No Results Yet
NCT05566704 | COMPLETED
123 Participants

Retrospective Modulus ALIF Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-08-18
Completion: 2022-10-15
Conditions
Degenerative Disc Disease Spondylolisthesis Stenosis
Interventions
DEVICE
No Results Yet
NCT05556876 | ENROLLING_BY_INVITATION | NA
123 Participants

Effect of Oral Nutritional Supplements to Older Patients Discharged With a Rehabilitation Plan

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-12-01
Completion: 2026-03-30
Conditions
Nutritional Risk Rehabilitation Oral Nutritional Supplements
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT05556681 | COMPLETED | NA
34 Participants

Study of BD Sirolimus Drug Coated Catheter for Treatment of Femoropopliteal Arteries

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-08-02
Completion: 2024-06-12
Conditions
Peripheral Arterial Disease Peripheral Artery Disease Stenosis Artery
Interventions
DEVICE
No Results Yet
NCT05552053 | RECRUITING | PHASE2/PHASE3
150 Participants

Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-06-01
Completion: 2026-06-01
Conditions
Stress, Psychological Racism Discrimination, Racial Inflammation Pregnancy Related Pregnancy Complications Pregnancy, High Risk Depression Depression, Postpartum Perinatal Depression Anxiety Anxiety in Pregnancy
Interventions
DEVICE
No Results Yet
NCT05537038 | COMPLETED | PHASE1
120 Participants

Safety and Immune Responses After Vaccination With Two Investigational RNA-based Vaccines Against Tuberculosis in Healthy Volunteers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-04-18
Completion: 2025-06-06
Conditions
Tuberculosis
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT05530538 | RECRUITING | NA
38 Participants

BrainWeighve App Feasibility Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-11-01
Completion: 2026-12-31
Conditions
Weight Loss Obesity and Overweight
Interventions
BEHAVIORAL
No Results Yet
NCT05526053 | COMPLETED | NA
1753 Participants

Lung Volume Preservation During Extubation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-01-15
Completion: 2024-08-13
Conditions
Weaning Failure Pulmonary Collapse
Interventions
OTHER
No Results Yet
NCT05519189 | ACTIVE_NOT_RECRUITING | PHASE4
134 Participants

Evaluation of the Value of Perianal Infiltration During Thermodestruction of Haemorrhoidal Disease by Radiofrequency

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-01-10
Completion: 2025-12-16
Conditions
Hemorrhoids
Interventions
DRUG OTHER
No Results Yet
NCT05508334 | COMPLETED | PHASE1/PHASE2
41 Participants

A Study to Assess the Safety and Tolerability of RC88 for Patients With Advanced Solid Tumours

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-01-30
Completion: 2025-11-26
Conditions
Advanced Solid Tumours
Interventions
DRUG
No Results Yet
NCT05505981 | COMPLETED | NA
64 Participants

An Immediate Functional Progression Program for Adolescent Athletes With Spondylolysis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-08-22
Completion: 2025-07-01
Conditions
Lumbar Spondylosis
Interventions
OTHER
No Results Yet
NCT05505500 | RECRUITING
150 Participants

Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-18
Completion: 2026-04-30
Conditions
Fluid Overload Glomerulosclerosis, Focal Segmental Edema Membranous Nephropathy Minimal Change Disease Minimal Change Nephrotic Syndrome IgM Nephropathy Nephrotic Syndrome Glomerular Disease Nephrotic Syndrome, Minimal Change Nephrotic Syndrome in Children Nephrotic Syndrome With Edema (Diagnosis) FSGS
Interventions
BEHAVIORAL
No Results Yet
NCT05494398 | ENROLLING_BY_INVITATION | PHASE2/PHASE3
144 Participants

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Open Label

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-03-12
Completion: 2027-09-30
Conditions
Autism Spectrum Disorder
Interventions
DRUG
No Results Yet
NCT05491655 | RECRUITING | NA
34 Participants

High Intensity His Bundle Pacing in Heart Failure Patients With Narrow QRS Outcome Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-03-29
Completion: 2026-02-28
Conditions
Cardiac Conduction System His Bundle Pacing Heart Failure Cardiomyopathies
Interventions
DEVICE
No Results Yet
NCT05490589 | RECRUITING | NA
90 Participants

Evaluation of the Implementation of a Parenting Program in Parents With Children Aged 4 to 12 Years and One Parent With an Alcohol Use Disorders

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-02-22
Completion: 2026-02-22
Conditions
Addiction, Alcohol
Interventions
OTHER
No Results Yet
NCT05485961 | RECRUITING | PHASE2/PHASE3
2310 Participants

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-10-21
Completion: 2029-08-30
Conditions
Atherosclerotic Cardiovascular Disease End Stage Kidney Disease Atherosclerotic Cardiovascular Disease in Patients With ESKD
Interventions
DRUG
No Results Yet
NCT05485402 | COMPLETED | NA
39 Participants

Dietary Strategy to Tackle Sarcopenia in Early Elderly Subjects (FOOP-Sarc)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-09-01
Completion: 2023-05-31
Conditions
Sarcopenia
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT05484115 | RECRUITING | NA
300 Participants

Comparison of EVAR and ESAR for Infrarenal Aortic Aneurysms With a Wide Proximal Neck

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-05-26
Completion: 2029-04-30
Conditions
Aortic Aneurysm, Abdominal
Interventions
DEVICE
No Results Yet
NCT05476926 | ACTIVE_NOT_RECRUITING
6000 Participants

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-21
Completion: 2027-03-31
Conditions
Neovascular Age-related Macular Degeneration Diabetic Macular Edema Retinal Vein Occlusion Branch Retinal Vein Occlusion Central Retinal Vein Occlusion Hemi-retinal Vein Occlusion
Interventions
DRUG COMBINATION_PRODUCT
No Results Yet
NCT05474274 | ENROLLING_BY_INVITATION
70 Participants

PAIN (Pain AI iNtervention) Platform for Patients at Home

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-23
Completion: 2026-11-30
Conditions
Pain
Interventions
OTHER
No Results Yet
NCT05467891 | RECRUITING | PHASE2
200 Participants

Ribociclib And Endocrine Treatment of Physician's Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-09-13
Completion: 2028-08-31
Conditions
Locoregional Recurrence Hormone Receptor-positive Breast Cancer HER2-negative Breast Cancer
Interventions
DRUG
No Results Yet
NCT05465109 | COMPLETED | NA
95 Participants

Traumatic Brain Injury and Alzheimer's Disease/Related Dementias Caregiver Support Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-07-01
Completion: 2025-06-28
Conditions
Caregiver Burden Caregiver Stress Syndrome Caregiver Burnout
Interventions
OTHER
No Results Yet
NCT05457556 | ACTIVE_NOT_RECRUITING | PHASE3
435 Participants

Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-03-15
Completion: 2026-06-30
Conditions
Acute Lymphoblastic Leukemia Acute Myeloid Leukemia Mixed Phenotype Acute Leukemia Myelodysplastic Syndrome
Interventions
PROCEDURE DRUG BIOLOGICAL OTHER RADIATION
No Results Yet
NCT05453578 | COMPLETED | PHASE1/PHASE2
72 Participants

A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-10-03
Completion: 2025-04-10
Conditions
Bacterial Disease Carrier Cystic Fibrosis
Interventions
OTHER BIOLOGICAL
No Results Yet
NCT05453162 | ACTIVE_NOT_RECRUITING | NA
52 Participants

Circadian Influence on Prolonged Exposure Therapy for PTSD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-07-01
Completion: 2025-08-01
Conditions
PTSD
Interventions
BEHAVIORAL
No Results Yet
NCT05444504 | RECRUITING | NA
100 Participants

Effectiveness and Acceptability of Insertable Devices for Obstetric Fistula Management

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-04-15
Completion: 2026-10-01
Conditions
Obstetric Fistula Fistula Fistula, Urinary Fistula, Vaginal
Interventions
DEVICE
No Results Yet
NCT05431686 | COMPLETED | NA
14 Participants

Group Visits for High Risk Type 1 Diabetes (T1D)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-16
Completion: 2025-07-01
Conditions
Type 1 Diabetes
Interventions
BEHAVIORAL
Results Available
NCT05423210 | RECRUITING | EARLY_PHASE1
12 Participants

Atezolizumab and Pre-Surgical Brain Radiation Therapy for Glioblastoma Multiforme

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-10-25
Completion: 2027-08-31
Conditions
Glioblastoma Multiforme
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05420948 | RECRUITING | PHASE2
30 Participants

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-10-17
Completion: 2026-12-01
Conditions
Head and Neck Cancer Head and Neck Squamous Cell Carcinoma Head and Neck Neoplasms Head Cancer Throat Carcinoma
Interventions
DRUG
No Results Yet
NCT05418764 | RECRUITING | NA
70 Participants

Effect of Validated Skills Simulation With the Miya Model

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-27
Completion: 2026-01-31
Conditions
Vaginal Hysterectomy
Interventions
OTHER
No Results Yet
NCT05417594 | RECRUITING | PHASE1/PHASE2
695 Participants

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-24
Completion: 2027-08-11
Conditions
Advanced Solid Malignancies
Interventions
DRUG
No Results Yet
NCT05416333 | RECRUITING | EARLY_PHASE1
15 Participants

Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-08-12
Completion: 2026-05-31
Conditions
Central Centrifugal Cicatricial Alopecia
Interventions
DRUG OTHER
No Results Yet
NCT05407324 | ACTIVE_NOT_RECRUITING | PHASE2
279 Participants

Dazucorilant in Patients With Amyotrophic Lateral Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-11-15
Completion: 2026-09-30
Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG OTHER
No Results Yet
NCT05391672 | RECRUITING | NA
30 Participants

Augmentation of Partial Anterior Cruciate Ligament Tear: Early Results

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-09
Completion: 2026-03-19
Conditions
ACL Injury ACL Augmentation
Interventions
PROCEDURE
No Results Yet
NCT05382338 | RECRUITING | PHASE3
225 Participants

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-02-20
Completion: 2027-12-20
Conditions
Childhood Medulloblastoma
Interventions
PROCEDURE DRUG OTHER RADIATION
No Results Yet
NCT05380453 | ACTIVE_NOT_RECRUITING | PHASE3
151 Participants

Efficacy and Safety of Secukinumab in Patients With New Onset of Giant Cell Arteritis Who Are in Clinical Remission

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-09-21
Completion: 2026-01-29
Conditions
Giant Cell Arteritis
Interventions
BIOLOGICAL DRUG
No Results Yet
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