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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05152524 | ACTIVE_NOT_RECRUITING | NA
168 Participants

Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-25
Completion: 2025-12-31
Conditions
Ischemic Stroke Neovascularization
Interventions
DEVICE
No Results Yet
NCT05126277 | RECRUITING | PHASE3
462 Participants

Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-07-14
Completion: 2027-06-22
Conditions
Lupus Nephritis
Interventions
DRUG
No Results Yet
NCT05124119 | COMPLETED
65 Participants

Strategies to Enhance Recruitment and Retention of Black Individuals Into Clinical Trials for Substance Use Disorders

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-01
Completion: 2022-12-01
Conditions
Substance Use Disorders
No Results Yet
NCT05123196 | COMPLETED | PHASE2
156 Participants

Exploratory Study of MT-8554 in Subjects With Painful Diabetic Peripheral Neuropathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-11-16
Completion: 2022-11-01
Conditions
Painful Diabetic Peripheral Neuropathy
Interventions
DRUG
No Results Yet
NCT05120570 | COMPLETED | PHASE1/PHASE2
16 Participants

PTCy + Sirolimus/VIC-1911 as GVHD Prophylaxis in Myeloablative PBSC Transplantation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-17
Completion: 2024-09-19
Conditions
Acute Leukemia Myelodysplastic Syndromes Myeloproliferative Neoplasm Lymphoma
Interventions
DRUG
Results Available
NCT05119296 | ACTIVE_NOT_RECRUITING | PHASE2
12 Participants

Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-15
Completion: 2025-05-16
Conditions
Thyroid Cancer
Interventions
DRUG
No Results Yet
NCT05117307 | NOT_YET_RECRUITING | NA
60 Participants

Comparison of Transversalis Fascia Plane Block and Erector Spinae Plane Blocks in Cesarean Section

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-12-20
Completion: 2026-06-15
Conditions
Pain Postoperative Pain
Interventions
DRUG
No Results Yet
NCT05094336 | RECRUITING | PHASE1/PHASE2
649 Participants

A Study of AMG 193 in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-01
Completion: 2026-07-02
Conditions
Advanced MTAP-null Solid Tumors
Interventions
DRUG
No Results Yet
NCT05089227 | RECRUITING | PHASE2
72 Participants

Efficacy of Prolonged Anticoagulation for Primary Prevention of Venous Thromboembolic Disease in Autoimmune Hemolytic Anemia: a Prospective, Phase II, Randomized, Multicenter Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-03
Completion: 2028-08-31
Conditions
Prolonged Anticoagulation Venous Thromboembolic Disease Autoimmune Hemolytic Anemia
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05081245 | ACTIVE_NOT_RECRUITING | PHASE2
150 Participants

ML-004 in Adolescents and Adults With Autism Spectrum Disorders (ASD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-09-13
Completion: 2026-10-31
Conditions
Autism Spectrum Disorder
Interventions
DRUG
No Results Yet
NCT05080764 | ACTIVE_NOT_RECRUITING | PHASE2
126 Participants

Study to Evaluate the Safety and Efficacy of BF-200 ALA (Ameluz®) and BF-RhodoLED® in the Treatment of Moderate to Severe Acne Vulgaris With Photodynamic Therapy in Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-10
Completion: 2025-08-22
Conditions
Acne Vulgaris
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05080465 | COMPLETED | PHASE3
700 Participants

Long Term Follow up Mesenchymal Stem Cell Therapy for Patients Virus-related Liver Cirrhosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2018-12-02
Completion: 2024-10-07
Conditions
Liver Cirrhosis
Interventions
BIOLOGICAL
No Results Yet
NCT05075824 | ACTIVE_NOT_RECRUITING | PHASE2
90 Participants

A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-09
Completion: 2025-06-11
Conditions
Sickle Cell Disease
Interventions
DRUG
No Results Yet
NCT05074277 | COMPLETED | NA
20 Participants

Skeletal Response to Simulated Night Shift

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-02-08
Completion: 2025-12-18
Conditions
Osteoporosis Circadian Rhythm Sleep Disorder, Shift Work Type
Interventions
BEHAVIORAL
No Results Yet
NCT05069038 | ACTIVE_NOT_RECRUITING | PHASE2
51 Participants

Clinical Trial Assessing the Safety of Neoadjuvant Palbociclib in Combination With Endocrine Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-02
Completion: 2026-09-30
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT05067569 | COMPLETED | NA
270 Participants

App-delivered Sleep ThERapy for Older Individuals With Insomnia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-10-01
Completion: 2025-01-31
Conditions
Insomnia
Interventions
BEHAVIORAL
No Results Yet
NCT05066711 | ENROLLING_BY_INVITATION
75 Participants

NuVasive® ACP System Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2022-05-22
Completion: 2026-09-30
Conditions
Cervical Spondylosis Cervical Radiculopathy Cervical Myelopathy Cervical Disc Disease Cervical Stenosis Cervical Disc Herniation Cervical Spine Disease
No Results Yet
NCT05063565 | ACTIVE_NOT_RECRUITING | PHASE2
100 Participants

TheraSphere With Durvalumab and Tremelimumab for HCC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2023-11-03
Completion: 2027-06-30
Conditions
Hepatocellular Carcinoma
Interventions
DEVICE DRUG
No Results Yet
NCT05060016 | ACTIVE_NOT_RECRUITING | PHASE2
222 Participants

A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-01
Completion: 2026-12-30
Conditions
Relapsed/Refractory Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT05039151 | COMPLETED
26 Participants

Interstitial Fluid Composition in Patients With Septic Versus Non-septic Shock: an Exploratory Pilot Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-25
Completion: 2025-07-19
Conditions
Interstitial Liquid Septic Shock
Interventions
BIOLOGICAL
No Results Yet
NCT05035836 | RECRUITING | PHASE2
20 Participants

A Phase 2 Single-Arm Open-Label Pilot Trial Evaluating Zanidatamab (ZW25) in Patients With Early Stage HER2/Neu Positive (HER2+) Breast Cancer (BC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-11-16
Completion: 2028-12-29
Conditions
Breast Cancer HER2-positive
Interventions
DRUG
No Results Yet
NCT05014204 | COMPLETED | NA
20 Participants

Safety and Feasibility of Novel Therapy for Duodenal Mucosal Regeneration for Type II Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-10-29
Completion: 2024-05-29
Conditions
Diabetes Diabetes Type 2 Diabetes Mellitus, Type 2 Glucose Metabolism Disorders Metabolic Disease Endocrine System Diseases Diabetes Mellitus
Interventions
DEVICE
Results Available
NCT04996628 | RECRUITING | NA
150 Participants

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-01-04
Completion: 2026-06-30
Conditions
Chronic Pancreatitis Chronic Pain
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04994132 | ACTIVE_NOT_RECRUITING | PHASE3
118 Participants

A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-14
Completion: 2027-09-30
Conditions
Alveolar Rhabdomyosarcoma Botryoid-Type Embryonal Rhabdomyosarcoma Embryonal Rhabdomyosarcoma Metastatic Embryonal Rhabdomyosarcoma Metastatic Rhabdomyosarcoma Solid Alveolar Rhabdomyosarcoma Spindle Cell Rhabdomyosarcoma Spindle Cell/Sclerosing Rhabdomyosarcoma
Interventions
PROCEDURE DRUG BIOLOGICAL RADIATION
No Results Yet
NCT04975347 | COMPLETED | PHASE1
47 Participants

Opioid Antagonism in Individuals Ascertained Through the Partners HealthCare Biobank

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-06-03
Completion: 2025-08-08
Conditions
Reproductive Disorders
Interventions
DRUG
No Results Yet
NCT04975334 | COMPLETED | PHASE1
23 Participants

Opioid Antagonism in Hypogonadotropic Hypogonadism

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-06-18
Completion: 2025-09-26
Conditions
Hypogonadotropic Hypogonadism Low Testosterone
Interventions
DRUG
No Results Yet
NCT04965298 | RECRUITING | PHASE3
298 Participants

Treating People With Idiopathic Pulmonary Fibrosis With the Addition of Lansoprazole

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-06-16
Completion: 2026-02-28
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
DRUG OTHER
No Results Yet
NCT04959279 | SUSPENDED | NA
26 Participants

ED-TREAT (Early Detection and Treatment to Reduce Events With Agitation Tool) Compared to Usual Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2026-03-01
Completion: 2026-08-01
Conditions
Psychomotor Agitation Behavioral Disorder
Interventions
OTHER
No Results Yet
NCT04953286 | COMPLETED | NA
55 Participants

Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-17
Completion: 2023-09-30
Conditions
Amyotrophic Lateral Sclerosis
Interventions
OTHER
No Results Yet
NCT04940299 | ACTIVE_NOT_RECRUITING | PHASE2
35 Participants

Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-23
Completion: 2027-12-31
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Locally Advanced Bladder Carcinoma Locally Advanced Bladder Urothelial Carcinoma Locally Advanced Lung Non-Small Cell Carcinoma Locally Advanced Renal Pelvis Carcinoma Locally Advanced Renal Pelvis Urothelial Carcinoma Locally Advanced Ureter Urothelial Carcinoma Locally Advanced Urethral Urothelial Carcinoma Malignant Solid Neoplasm Metastatic Bladder Carcinoma Metastatic Bladder Urothelial Carcinoma Metastatic Lung Non-Small Cell Carcinoma Metastatic Melanoma Metastatic Renal Pelvis Urothelial Carcinoma Metastatic Ureter Urothelial Carcinoma Metastatic Urethral Carcinoma Metastatic Urethral Urothelial Carcinoma Pathologic Stage III Cutaneous Melanoma AJCC v8 Pathologic Stage IIIA Cutaneous Melanoma AJCC v8 Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 Pathologic Stage IIID Cutaneous Melanoma AJCC v8 Pathologic Stage IV Cutaneous Melanoma AJCC v8 Stage III Bladder Cancer AJCC v8 Stage III Lung Cancer AJCC v8 Stage III Renal Pelvis Cancer AJCC v8 Stage III Ureter Cancer AJCC v8 Stage III Urethral Cancer AJCC v8 Stage IIIA Bladder Cancer AJCC v8 Stage IIIA Lung Cancer AJCC v8 Stage IIIB Bladder Cancer AJCC v8 Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8 Stage IV Bladder Cancer AJCC v8 Stage IV Lung Cancer AJCC v6 Stage IV Renal Pelvis Cancer AJCC v8 Stage IV Ureter Cancer AJCC v8 Stage IV Urethral Cancer AJCC v8 Stage IVA Lung Cancer AJCC v8 Stage IVB Lung Cancer AJCC v8 Unresectable Melanoma
Interventions
BIOLOGICAL
No Results Yet
NCT04939597 | ACTIVE_NOT_RECRUITING | PHASE3
192 Participants

A Study to See if Memantine Protects the Brain During Radiation Therapy Treatment for a Brain Tumor

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-05-10
Completion: 2026-06-30
Conditions
Central Nervous System Carcinoma
Interventions
PROCEDURE DRUG OTHER
No Results Yet
NCT04936178 | COMPLETED | PHASE1
258 Participants

A Study of NB003 in Patients With Advanced Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-08-06
Completion: 2025-08-01
Conditions
Advanced Solid Tumor
Interventions
DRUG
No Results Yet
NCT04920604 | COMPLETED | NA
172 Participants

Anesthetic and Perioperative Risk Assessment Before Programmed Surgery: Anesthetic Teleconsultation Versus Face-to-face Anesthesia Consultation.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-05-20
Completion: 2022-04-21
Conditions
Telemedicine Anesthesia Consultation, Remote
Interventions
OTHER
No Results Yet
NCT04916522 | ACTIVE_NOT_RECRUITING | PHASE2
150 Participants

The COlchicine HypERtENsion Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-08-10
Completion: 2026-01-31
Conditions
Hypertension
Interventions
DRUG
No Results Yet
NCT04886804 | RECRUITING | PHASE1
554 Participants

Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-07-02
Completion: 2026-12-30
Conditions
Neoplasm Metastasis Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT04879277 | COMPLETED | NA
40 Participants

Study of Low-grade Systemic Inflammation in Adult Patients With Phenylketonuria

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-05-26
Completion: 2021-08-25
Conditions
Phenylketonuria
Interventions
BIOLOGICAL
No Results Yet
NCT04870944 | RECRUITING | PHASE1/PHASE2
63 Participants

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-01-28
Completion: 2026-12-31
Conditions
Diffuse Midline Glioma, H3 K27-Altered Metastatic Malignant Neoplasm in the Central Nervous System Recurrent Diffuse Intrinsic Pontine Glioma Recurrent Diffuse Midline Glioma, H3 K27-Altered Recurrent Lymphoma Recurrent Malignant Solid Neoplasm Recurrent Primary Malignant Central Nervous System Neoplasm Refractory Lymphoma Refractory Malignant Solid Neoplasm Refractory Primary Malignant Central Nervous System Neoplasm
Interventions
PROCEDURE DRUG
No Results Yet
NCT04855370 | WITHDRAWN | NA
0 Participants

Non-Invasive Measurement of Cardiac Output and Stroke Volume in PE

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2025-07-15
Completion: 2026-01-31
Conditions
Pulmonary Embolism Pulmonary Embolus/Emboli Pulmonary Disease Pulmonary Embolism and Thrombosis Pulmonary Embolism Subacute Massive Pulmonary Embolism Acute Massive
Interventions
DEVICE
No Results Yet
NCT04854278 | RECRUITING
400 Participants

Introduction of an Operating Room Black Box to Identify, Analyse and Prevent Errors in the Vascular Hybrid Room

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2019-02-19
Completion: 2027-12-31
Conditions
Patient Safety Endovascular Procedures Quality Improvement
Interventions
OTHER
No Results Yet
NCT04853251 | RECRUITING | PHASE4
188 Participants

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-12-14
Completion: 2028-03-31
Conditions
Neovascular Age-related Macular Degeneration
Interventions
DEVICE DRUG
No Results Yet
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