The COlchicine HypERtENsion Trial

NCT ID: NCT04916522

Last Updated: 2025-12-22

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 150 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-08-10
• Study Completion Date: 2026-01-31

Brief Summary

The purpose of this study to investigate the effects of colchicine on measures of vascular and cardiac function in patients with hypertension.

Detailed Description

The study is an investigator-initiated, prospective, double-blind, placebo-controlled, randomized clinical trial investigating the effects of colchicine in patients with hypertension. The study population will consist of approximately 150 patients aged 18 years and above with a diagnosis of hypertension and in active treatment with at least 1 antihypertensive drug. Patients will be randomized to either low-dose colchicine treatment (0,5 mg once daily) or placebo. Treatment will continue for 6 months. Patients will be assessed by measurement of pulse wave velocity (PWV), office blood pressure, echocardiography, cardiac MRI, and blood samples at baseline and after 6 months.

Conditions

Hypertension

Keywords

Inflammation; Vascular Stiffness; Pulse Wave Analysis; Blood Pressure; Echocardiography; Magnetic Resonance Imaging; Computed Tomography Angiography; Hypertrophy, Left Ventricular; Ventricular Function, Left; Endomyocardial Fibrosis; Atherosclerosis; Coronary Atherosclerosis; Colchicine; Cardiovascular Diseases; Heart Diseases; Randomized Controlled Trial

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Colchicine

Colchicine 0.5 mg once daily

Group Type: EXPERIMENTAL

Colchicine

Intervention Type: DRUG

0.5 mg once daily

Placebo

Placebo once daily

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Once daily

Interventions

Colchicine

0.5 mg once daily

Intervention Type: DRUG

Placebo

Once daily

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Living address in the Capital Region of Denmark

2. Age >18 years

3. Diagnosed with hypertension

4. Treatment with 1 or more antihypertensive medications

5. Must fulfill at least one of the following high-risk criteria:

1. Diagnosed with type 2 diabetes mellitus OR

2. Treatment with lipid-lowering medication for dyslipidemia OR

3. Treatment with 2 or more antihypertensive medications

6. Female patients should either not be of childbearing potential, defined as postmenopausal for at least 1 year or surgically sterile, or is of childbearing potential and practicing one of the following methods of contraception throughout the study and for 30 days after study completion: Hormonal contraception (oral contraceptives, contraceptive implant, injectable birth control, contraceptive patch, or vaginal ring) or intrauterine device

7. Patients will have given written, informed consent and are able and willing to comply with the requirements of the study protocol

Exclusion Criteria

1. Colchicine treatment for another cause, e.g. gout

2. Allergy/hypersensitivity to colchicine

3. Known or suspected secondary hypertension, e.g. renal artery stenosis

4. Uncontrolled hypertension (systolic BP >180 mmHg or diastolic BP >110 mmHg)

5. Known other cardiovascular disease (judged by the investigator), e.g. ischemic heart disease, heart failure, significant valvular disease, arrhythmia, stroke, or peripheral artery disease

6. History of malignancy of any organ system excluding a successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma, localized prostate cancer and/or localized carcinoma in situ of the cervix

7. Cirrhosis, chronic active hepatitis or other severe hepatic disease

8. Hemodialysis

9. Estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2

10. Systemic treatment with moderate or strong cytochrome P450 3A4 (CYP3A4) inhibitors or P-glycoprotein inhibitors

11. Anemia, thrombocytopenia or leucopenia defined as any of the following measurements within the last 3 months:

1. Hemoglobin < 7 mmol/L

2. Platelet count < 110 x 10^9/L

3. White blood cell count < 3.0 x 10^9/L

12. Female patients who are pregnant, lactating, or considering becoming pregnant during the study or for 6 months after study completion

13. Significant drug or alcohol abuse during the last year

14. Current use of or plans to initiate chronic systemic steroid therapy during the study (topical or inhaled steroids are allowed)

15. Chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis) or chronic diarrhea

16. Use of other investigational drugs within 30 days of the time of enrollment

17. Any surgical or medical condition, which in the opinion of the investigator, may place the patient at higher risk from his/her participation in the study, or is likely to prevent the patient from complying with the requirements of the study or completing the study.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Copenhagen

OTHER

Sponsor Role: collaborator

Herlev and Gentofte Hospital

OTHER

Sponsor Role: lead

Responsible Party

Niklas Dyrby Johansen

Principal Investigator, MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Niklas Dyrby Johansen, MD

Role: PRINCIPAL_INVESTIGATOR

Herlev and Gentofte Hospital

Locations

Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Herlev and Gentofte Hospital

Hellerup, , Denmark

Countries

Denmark

Other Identifiers

2020-004492-40

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

COHERENT

Identifier Type: -

Identifier Source: org_study_id