Clinical Trials

Showing trials with last updates posted in 2025.

NCT05757869 | ACTIVE_NOT_RECRUITING | PHASE3
20283 Participants

A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-04-11
Completion: 2026-10-31
Conditions
Atrial Fibrillation
Interventions
DRUG
No Results Yet
NCT05747625 | RECRUITING | PHASE1
60 Participants

(89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-05-09
Completion: 2027-02-28
Conditions
Head and Neck Squamous Cell Carcinoma Metastatic Head and Neck Squamous Cell Carcinoma Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck
Interventions
BIOLOGICAL DRUG PROCEDURE OTHER
No Results Yet
NCT05745493 | COMPLETED | NA
29 Participants

Study 1: Social Engage Coaching R61 Phase

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-06-13
Completion: 2025-09-30
Conditions
Social Isolation Loneliness Suicide Ideation Quality of Life
Interventions
BEHAVIORAL
No Results Yet
NCT05741580 | COMPLETED
70 Participants

Peri-urethral Bulk Agent Injection of Bulkamid®

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-01
Completion: 2022-11-30
Conditions
Urinary Incontinence
Interventions
PROCEDURE
No Results Yet
NCT05727384 | ACTIVE_NOT_RECRUITING | PHASE2
29 Participants

Improving Physical Function in Older Adults Using an Anti-inflammation Drug: The RIGHT Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-08-01
Completion: 2026-02-28
Conditions
Inflammation Frailty
Interventions
DRUG
No Results Yet
NCT05716100 | RECRUITING | PHASE3
360 Participants

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-05-09
Completion: 2026-10-31
Conditions
Focal Onset Seizures
Interventions
DRUG
No Results Yet
NCT05714202 | ACTIVE_NOT_RECRUITING | PHASE3
1135 Participants

A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-03-23
Completion: 2029-09-18
Conditions
Bladder Cancer
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05714085 | RECRUITING | PHASE2/PHASE3
342 Participants

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-05-31
Completion: 2032-04-15
Conditions
Heart Failure Left Ventricular Systolic Dysfunction
Interventions
DRUG
No Results Yet
NCT05702034 | RECRUITING | PHASE3
15000 Participants

A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-02-15
Completion: 2026-11-11
Conditions
Ischemic Stroke; Ischemic Attack, Transient
Interventions
DRUG
No Results Yet
NCT05696392 | TERMINATED | PHASE4
47 Participants

The Purpose of This Study is to Evaluate the Effects of Ruxolitinib Cream on Adults With Atopic Dermatitis Experiencing Sleep Disturbance.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-03-16
Completion: 2025-01-22
Conditions
Atopic Dermatitis
Interventions
DRUG
NCT05675449 | RECRUITING | PHASE1
90 Participants

A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-12-14
Completion: 2026-04-22
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05667142 | RECRUITING | PHASE3
160 Participants

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-02-14
Completion: 2027-04-30
Conditions
Primary Generalized Tonic-Clonic Seizures
Interventions
DRUG
No Results Yet
NCT05663203 | RECRUITING | NA
56 Participants

A Web-Based Dyadic Intervention for Colorectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-05-01
Completion: 2026-10-01
Conditions
Colorectal Carcinoma
Interventions
OTHER
No Results Yet
NCT05661916 | COMPLETED | PHASE1
96 Participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy Subjects

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-16
Completion: 2025-09-30
Conditions
Transthyretin-Mediated Amyloidosis
Interventions
DRUG
No Results Yet
NCT05637112 | ACTIVE_NOT_RECRUITING
551 Participants

A Treatment Effectiveness Study Among SLE Patients Receiving Anifrolumab in Routine Clinical Practice

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2023-02-27
Completion: 2030-12-30
Conditions
Systemic Lupus Erythematosus
Interventions
OTHER
No Results Yet
NCT05629585 | ACTIVE_NOT_RECRUITING | PHASE3
1174 Participants

A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-11-28
Completion: 2027-09-20
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT05628948 | RECRUITING
500 Participants

Vascular Lab Resource (VLR) Biorepository

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2019-11-14
Completion: 2030-12-31
Conditions
Cardiovascular Diseases Metabolic Disease Peripheral Artery Disease Carotid Disease Aneurysmal Disease Venous Disease Thrombosis Lymphedema Lipedema Non-Atherosclerotic Chronic Arterial Occlusive Disease Vasculitis Fibromuscular Dysplasia Arterial Dissection May-Thurner Syndrome Thoracic Outlet Syndrome Vasospasm
No Results Yet
NCT05616793 | RECRUITING | PHASE1/PHASE2
22 Participants

Safety and Tolerability Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD) and Non-interventional Arm With Untreated Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-06-15
Completion: 2028-06-15
Conditions
LCA5
Interventions
BIOLOGICAL
No Results Yet
NCT05616273 | COMPLETED
62 Participants

Stimulated Glucagon as a Biomarker of Hypoglycemic Risk in Type 1 Diabetes

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2023-05-03
Completion: 2025-01-28
Conditions
Type 1 Diabetes Hypoglycemia
Interventions
OTHER
No Results Yet
NCT05614063 | ACTIVE_NOT_RECRUITING | PHASE3
360 Participants

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-11-18
Completion: 2025-12-31
Conditions
Focal Onset Seizures
Interventions
DRUG
No Results Yet
NCT05590377 | TERMINATED | PHASE1/PHASE2
15 Participants

A Study of Modakafusp Alfa Together With Daratumumab Adults With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-23
Completion: 2024-05-22
Conditions
Multiple Myeloma
Interventions
DRUG
NCT05582187 | COMPLETED | PHASE1
28 Participants

A Clinical Trial of the Study Medicine (Called Fosmanogepix) in Participants With Varying Degrees of Hepatic Function.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-31
Completion: 2025-10-16
Conditions
Hepatic Impairment
Interventions
DRUG
No Results Yet
NCT05575700 | COMPLETED | PHASE4
2904 Participants

Safety of Ibuprofen After Major Orthopaedic Surgeries

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-04-17
Completion: 2025-08-19
Conditions
Safety Issues Analgesia Analgesic Adverse Reaction Postoperative Pain Postoperative Complications Knee Arthropathy Pain, Acute Hip Arthropathy
Interventions
DRUG
No Results Yet
NCT05572905 | COMPLETED | NA
60 Participants

Effect of Acute Bout of Exercise on Levels of PAHSA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-05-01
Completion: 2025-12-12
Conditions
Insulin Sensitivity
Interventions
OTHER
No Results Yet
NCT05572515 | ACTIVE_NOT_RECRUITING | PHASE3
614 Participants

A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-03-29
Completion: 2026-02-13
Conditions
Relapsed or Refractory Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05568459 | ACTIVE_NOT_RECRUITING
11 Participants

A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement Therapy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2024-01-17
Completion: 2026-01-21
Conditions
Hemophilia B
Interventions
OTHER
No Results Yet
NCT05565560 | ACTIVE_NOT_RECRUITING | PHASE3
17 Participants

A Study to Assess the Efficacy and Safety of Apremilast in Japanese Pediatric Participants With Moderate to Severe Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-25
Completion: 2025-11-20
Conditions
Plaque Psoriasis
Interventions
DRUG
No Results Yet
NCT05557201 | RECRUITING
700 Participants

Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-24
Completion: 2027-10-31
Conditions
Miscarriage Early Pregnancy Loss
No Results Yet
NCT05556616 | TERMINATED | PHASE1
15 Participants

A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-12
Completion: 2024-06-04
Conditions
Multiple Myeloma
Interventions
DRUG
NCT05552222 | RECRUITING | PHASE3
1590 Participants

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-25
Completion: 2031-04-30
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05517434 | RECRUITING | PHASE2/PHASE3
148 Participants

Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2025-01-01
Completion: 2026-06-30
Conditions
Osteoarthritis, Knee
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT05499013 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
69 Participants

Study to Assess SLN124 in Patients With Polycythemia Vera

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-26
Completion: 2026-09-30
Conditions
Polycythemia Vera
Interventions
DRUG
No Results Yet
NCT05498428 | RECRUITING | PHASE2
520 Participants

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-11-11
Completion: 2027-08-17
Conditions
Carcinoma, Non-small-Cell Lung
Interventions
DRUG
No Results Yet
NCT05493982 | ENROLLING_BY_INVITATION | NA
10800 Participants

Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-19
Completion: 2026-06-01
Conditions
E-cigarette Use
Interventions
BEHAVIORAL
No Results Yet
NCT05490238 | RECRUITING | NA
708 Participants

DIStal Versus COnventional Radial Access for COMPLEX Large-bore Percutaneous Coronary Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-08-31
Completion: 2026-06-01
Conditions
Vascular Access Site Occlusion
Interventions
PROCEDURE
No Results Yet
NCT05488314 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
57 Participants

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-12-13
Completion: 2026-06-09
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
No Results Yet
NCT05479006 | RECRUITING | NA
30 Participants

Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-09-30
Completion: 2026-06-30
Conditions
Stroke
Interventions
DEVICE
No Results Yet
NCT05477004 | ENROLLING_BY_INVITATION
100 Participants

Observational Study of Ketamine Infusions for the Treatment of Chronic Pain

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-06-01
Completion: 2026-12-31
Conditions
Chronic Pain
Interventions
DRUG
No Results Yet
NCT05475002 | COMPLETED | NA
92 Participants

A Care Empowerment Program Using Virtual Reality for Family Caregivers of People With Dementia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-01
Completion: 2023-07-01
Conditions
Dementia Family Caregiver
Interventions
OTHER
No Results Yet
NCT05465343 | COMPLETED | PHASE2
24 Participants

Furmonertinib in EGFR-Mutant NSCLC With Brain Metastases (iFORCE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-11
Completion: 2025-12-12
Conditions
Furmonertinib EGFR-mutation NSCLC Brain Metastases
Interventions
DRUG
No Results Yet
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