Peri-urethral Bulk Agent Injection of Bulkamid®

NCT ID: NCT05741580

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-01

Study Completion Date

2022-12-31

Brief Summary

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There are currently different treatment options in the management of stress urinary incontinence according to the latest recommendations. Suburethral slings are currently considered the first surgical option due to an excellent cure rate of around 90%. Nevertheless, due to a risk of prosthetic complications and numerous current controversies over the placement of synthetic tissue, other therapeutic alternatives must be offered to patients.

Peri-urethral bulk agent injections have been used since 2006 in urinary incontinence and should be integrated into the therapeutic arsenal. This is a minimally invasive technique performed under local anesthesia on an outpatient basis. The mechanism of action is explained by better coaptation of the urethra and increased resistance to urine flow during the bladder filling phase. It also increases the strength of the striated sphincter thanks to a better arrangement of muscle fibers.

According to the European Association of Urology (EAU), the use of bulk agents is recommended for the management of urinary incontinence in elderly and/or frail patients whose comorbidities contraindicate surgical management. These peri-urethral injections can also be offered to patients with incontinence due to sphincter deficiency but also to young women with stress urinary incontinence who are ready to accept a partial improvement in their incontinence. The personal choice of the patient is currently a decisive factor for the implementation of a treatment for functional disorders and in particular for urinary incontinence.

Detailed Description

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Conditions

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Urinary Incontinence

Keywords

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Bulkamid® bulk agent peri-urethral injection urinary incontinence

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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peri-urethral bulk agent injection of Bulkamid® for urinary incontinence

patients who received a first injection of Bulkamid® in the context of urinary incontinence

Evolution of symptoms

Intervention Type PROCEDURE

percentage of patients with improvement in their symptoms

Interventions

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Evolution of symptoms

percentage of patients with improvement in their symptoms

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* women over 18
* patients who received a first peri-urethral injection of Bulkamid® in the context of urinary incontinence
* intervention between September 2020 and November 2022
* person having expressed his non-opposition

Exclusion Criteria

* inability to understand the information given
* person deprived of liberty
* person under guardianship
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Service de Gynécologie, HFME, Hospices Civils de Lyon

Bron, , France

Site Status

Countries

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France

Other Identifiers

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69HCL22_1157

Identifier Type: OTHER

Identifier Source: secondary_id

22-5093

Identifier Type: -

Identifier Source: org_study_id