Clinical Trials Updated in 2025

NCT06894498 | NOT_YET_RECRUITING

100 Participants

Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss

Study Type: OBSERVATIONAL

Last Updated: 2025-12-18

Start Date: 2026-01-31

Completion: 2026-10-31

Conditions

Obesity and Obesity-related Medical Conditions Weight Loss

Interventions

OTHER

No Results Yet

NCT06880523 | RECRUITING | PHASE2

140 Participants

STRIDE (Durvalumab + Tremelimumab) With Lenvatinib vs STRIDE Alone in Unresectable Hepatocellular Carcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-10-21

Completion: 2028-01-31

Conditions

Hepatocellular Carcinoma

Interventions

DRUG

No Results Yet

NCT06865989 | COMPLETED | NA

132 Participants

Omnipod® SmartAdjust 2.0 System Compared to the Omnipod® 5 System in Individuals With Type 1 or Type 2 Diabetes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-03-26

Completion: 2025-11-10

Conditions

Diabetes Mellitus, Type 1, Type 2

Interventions

DEVICE

No Results Yet

NCT06865105 | RECRUITING | PHASE2

120 Participants

Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-04-11

Completion: 2027-12-31

Conditions

Psoriatic Arthritis

Interventions

DRUG

No Results Yet

NCT06861881 | NOT_YET_RECRUITING | NA

100 Participants

Continuous Glucose Monitoring in Patients Undergoing Cardiopulmonary Bypass

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2026-01-31

Completion: 2026-10-31

Conditions

Glucose Metabolism Disorders (Including Diabetes Mellitus)

Interventions

DEVICE

No Results Yet

NCT06861361 | RECRUITING | NA

1180 Participants

Surgical vs Transcatheter Aortic Valve Replacement in Young Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-05-15

Completion: 2027-11-30

Conditions

Symptomatic Severe Aortic Stenosis

Interventions

DEVICE

No Results Yet

NCT06851793 | COMPLETED

110 Participants

Investigating Postural Parameters in Different Hip Pathologies

Study Type: OBSERVATIONAL

Last Updated: 2025-12-18

Start Date: 2025-10-02

Completion: 2025-11-10

Conditions

Hip Injuries and Disorders

No Results Yet

NCT06847646 | COMPLETED | NA

74 Participants

Evaluation of Bioflex Crowns Using the Hall Technique in Primary Molars

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2024-08-20

Completion: 2025-08-20

Conditions

BioFlex Crowns Using Hall Technique

Interventions

OTHER

No Results Yet

NCT06842654 | RECRUITING

20 Participants

EORTC Quality of Life Measurement Strategies in Progressive Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-12-18

Start Date: 2025-08-13

Completion: 2026-03-31

Conditions

Cancer

No Results Yet

NCT06840288 | RECRUITING

250 Participants

Bronchoscopic Lung Ablation of Small Thoracic Tumors: the Blastt Registry

Study Type: OBSERVATIONAL

Last Updated: 2025-12-18

Start Date: 2025-02-19

Completion: 2034-12-31

Conditions

Thoracic Tumors

No Results Yet

NCT06837662 | RECRUITING | NA

70 Participants

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-03-24

Completion: 2026-03-21

Conditions

Opioid Dependence Substance Abuse Disorders Complex Medical Patients Primary Care Patients With Chronic Conditions

Interventions

BEHAVIORAL

No Results Yet

NCT06833281 | TERMINATED | PHASE2

12 Participants

Extension Study of Participants From SPG302-ALZ-101

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-03-25

Completion: 2025-07-30

Conditions

Alzheimer's Disease

Interventions

DRUG

No Results Yet

NCT06832618 | RECRUITING | PHASE3

240 Participants

A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children and Adolescents (6 to <18 Years Old) With Moderate Atopic Dermatitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-06-17

Completion: 2026-07-13

Conditions

Atopic Dermatitis

Interventions

DRUG

No Results Yet

NCT06827860 | RECRUITING | PHASE2

23 Participants

Subcutaneous Talquetamab in Elderly Patients With Multiple Myeloma in Early Relapse

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-11-18

Completion: 2027-01-31

Conditions

Multiple Myeloma in Relapse

Interventions

DRUG

No Results Yet

NCT06826768 | RECRUITING | PHASE1

60 Participants

A Ph Ib Study of REGN5678 Plus Cemiplimab in Patients With mCRPC

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-07-09

Completion: 2027-05-01

Conditions

Prostate Cancer

Interventions

DRUG

No Results Yet

NCT06825494 | RECRUITING | PHASE1/PHASE2

194 Participants

Clinical Studies for the Treatment of Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-04-08

Completion: 2026-03-31

Conditions

Advanced Solid Tumor

Interventions

DRUG

No Results Yet

NCT06823388 | COMPLETED | NA

30 Participants

Assessment of Acupuncture on Eye Fatigue

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2024-08-01

Completion: 2024-12-30

Conditions

Acupuncture Eye Fatigue Accomodation

Interventions

DEVICE

No Results Yet

NCT06822530 | ENROLLING_BY_INVITATION | NA

682 Participants

A Multilevel Intervention to Increase Colorectal Cancer Screening Tests in Patients With Abnormal Fecal Immunochemical Test Results, PROACT Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-12-16

Completion: 2028-06-30

Conditions

Colorectal Carcinoma

Interventions

OTHER

No Results Yet

NCT06821126 | RECRUITING | PHASE1/PHASE2

238 Participants

Study Comparing Safety and Immunogenicity of Intranasal COVID-19 Vaccine and mRNA Booster in Healthy Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-05-09

Completion: 2026-10-31

Conditions

Healthy

Interventions

BIOLOGICAL

No Results Yet

NCT06817421 | NOT_YET_RECRUITING | PHASE4

214 Participants

Opportunistic Pneumococcal Immunisation Trial in MALnutrition

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2026-01-31

Completion: 2028-03-31

Conditions

Severe Acute Malnutrition in Childhood Pneumococcal Disease Pneumococcal Vaccines Pneumococcal Infection Pneumonia in Children

Interventions

BIOLOGICAL

No Results Yet

NCT06812325 | ACTIVE_NOT_RECRUITING | PHASE3

321 Participants

A Safety and Tolerability Study of VRDN-003 in Participants With Thyroid Eye Disease (TED)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-02-03

Completion: 2026-04-30

Conditions

Thyroid Eye Disease (TED)

Interventions

DRUG

No Results Yet

NCT06809998 | RECRUITING | PHASE1/PHASE2

60 Participants

COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-01-24

Completion: 2026-04-30

Conditions

Total Knee Anthroplasty Osteoarthritis(Primary) Osteoarthritis (OA) of the Knee Bilateral Knee Osteoarthritis

Interventions

DRUG OTHER

No Results Yet

NCT06807359 | RECRUITING | PHASE1/PHASE2

43 Participants

Photodynamic Therapy of Primary Localized Prostate Cancer With the SpectraCure P18 System

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-01-06

Completion: 2028-01-31

Conditions

Prostate Cancer

Interventions

DEVICE DRUG

No Results Yet

NCT06799702 | NOT_YET_RECRUITING | NA

50 Participants

Trauma-informed, Resilience-based Telehealth Intervention for Improving HIV Prevention and HCV Care for Persons Who Inject Drugs in the Deep South (Pilot Testing: Aim3)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2026-08-01

Completion: 2028-03-31

Conditions

HIV Pre-exposure Prophylaxis HEPATITIS C (HCV) Opioid Use Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT06797817 | NOT_YET_RECRUITING | PHASE3

156 Participants

Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2026-06-01

Completion: 2026-09-01

Conditions

Alzheimer Disease (AD)

Interventions

DIETARY_SUPPLEMENT OTHER

No Results Yet

NCT06797336 | RECRUITING | PHASE1

115 Participants

A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2024-12-19

Completion: 2026-12-15

Conditions

Solid Tumor

Interventions

DRUG

No Results Yet

NCT06793215 | RECRUITING | PHASE3

600 Participants

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-10-24

Completion: 2028-11-30

Conditions

Non-Small Cell Lung Cancer KRAS G12C Lung Cancer

Interventions

DRUG

No Results Yet

NCT06786455 | COMPLETED | PHASE2

9 Participants

Pharmacokinetics, Pharmacodynamics, Safety, and Preliminary Efficacy of Subcutaneous Injection of SHR-1905 in Adolescent Asthmatic Subjects - an Open-label, Single-dose Phase II Clinical Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-01-23

Completion: 2025-12-03

Conditions

Adolescent Asthma

Interventions

DRUG

No Results Yet

NCT06785272 | RECRUITING | PHASE3

192 Participants

Magnesium Trial in Acute Asthma in Emergency Department

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-10-08

Completion: 2027-10-31

Conditions

Asthma

Interventions

DRUG

No Results Yet

NCT06775171 | COMPLETED | NA

270 Participants

Impact of Video-Based Pressure Injury Training on Caregivers' Knowledge, Attitudes, Behaviors & Reactions

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2024-01-14

Completion: 2024-12-14

Conditions

Pressure Injury

Interventions

BEHAVIORAL

No Results Yet

NCT06774027 | RECRUITING

100 Participants

Prospective Registry of ADC as First- and Second-line Treatment for Breast Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-12-18

Start Date: 2025-10-08

Completion: 2030-12-31

Conditions

HER2-negative Breast Cancer HER2 Negative Breast Carcinoma Metastatic Breast Cancer HR+ HER2 Breast Cancer Metastatic Triple Negative Breast Cancers Metastatic Triple-Negative Breast Carcinoma

Interventions

PROCEDURE DRUG OTHER

No Results Yet

NCT06770491 | COMPLETED | PHASE1

20 Participants

A Phase 1 Study of Y-3 in US Healthy Volunteers.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-02-04

Completion: 2025-09-20

Conditions

Safety Tolerability Pharmacokinetic Study in Healthy Volunteers

Interventions

DRUG

No Results Yet

NCT06768983 | COMPLETED | NA

5 Participants

Fatigue Reduction in Chronic Kidney Disease (CKD)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-01-30

Completion: 2025-09-16

Conditions

Chronic Kidney Diseases Fatigue

Interventions

BEHAVIORAL

No Results Yet

NCT06761586 | RECRUITING | PHASE1

42 Participants

A Study of AUR104 in Patients With Relapsed/Refractory Lymphoid Malignancies (VIJAY-1)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2024-12-12

Completion: 2026-11-04

Conditions

Select Relapsed/Refractory Lymphoid Malignancies

Interventions

DRUG

No Results Yet

NCT06748898 | COMPLETED | NA

60 Participants

Effect of Transcutaneous Electrical Nerve Stimulation Based on Wrist-ankle Acupuncture Theory on EC50 of Remifentanil Inhibiting Responses to Tracheal Intubation Under General Anesthesia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-02-06

Completion: 2025-11-14

Conditions

Perioperative Analgesia General Anaesthesia

Interventions

OTHER

No Results Yet

NCT06741514 | ENROLLING_BY_INVITATION

100 Participants

A Study of Precice Intramedullary Limb Lengthening System (IMLL) Limb Lengthening Procedures

Study Type: OBSERVATIONAL

Last Updated: 2025-12-18

Start Date: 2024-03-25

Completion: 2026-07-01

Conditions

Limb Length Discrepancy

Interventions

DEVICE

No Results Yet

NCT06739122 | RECRUITING | PHASE3

55 Participants

A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-01-10

Completion: 2026-06-30

Conditions

Type 2 Diabetes

Interventions

DRUG

No Results Yet

NCT06736613 | RECRUITING | PHASE2

50 Participants

A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2024-12-11

Completion: 2027-12-11

Conditions

Diffuse Large B Cell Lymphoma High-grade B-cell Lymphoma Stage III High Grade B-Cell Lymphoma Stage IV High Grade B-Cell Lymphoma DLBCL - Diffuse Large B Cell Lymphoma Intravascular Large B-Cell Lymphoma Diffuse Large B Cell Lymphoma of Breast Diffuse Large B Cell Lymphoma of Testis HIV-associated Diffuse Large B Cell Lymphoma Double Expressor DLBCL

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06736028 | RECRUITING | NA

20 Participants

Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-08-01

Completion: 2026-06-30

Conditions

Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT06733675 | RECRUITING | PHASE1

46 Participants

Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination

Study Type: INTERVENTIONAL

Last Updated: 2025-12-18

Start Date: 2025-01-07

Completion: 2026-06-30

Conditions

Healthy Volunteer Pharmacokinetics Safety Drug-Drug Interaction (DDI) FDC

Interventions

DRUG

No Results Yet