Clinical Trials

Showing trials with last updates posted in 2025.

NCT04906213 | ACTIVE_NOT_RECRUITING | PHASE2
20 Participants

CardioRenal Effects of SGLT2 Inhibition in Kidney Transplant Recipients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-07-25
Completion: 2026-01-23
Conditions
Kidney Transplant; Complications Diabetes Mellitus, Type 2
Interventions
DRUG
No Results Yet
NCT04895709 | RECRUITING | PHASE1/PHASE2
949 Participants

A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-05-27
Completion: 2028-07-07
Conditions
Cervical Cancer Gastric/Gastroesophageal Junction Adenocarcinoma Microsatellite Stable Colorectal Cancer Non-Small-Cell Lung Cancer Squamous Cell Carcinoma of Head and Neck Carcinoma, Renal Cell Urothelial Carcinoma Pancreatic Adenocarcinoma Melanoma Ovarian Neoplasms Triple Negative Breast Neoplasms
Interventions
DRUG
No Results Yet
NCT04894734 | RECRUITING | NA
30 Participants

Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-12-30
Completion: 2025-12-31
Conditions
Spinal Cord Injury at T1-T12 Level Traumatic Thoracic Spinal Cord Contusion Thoracic Spinal Cord Trauma Traumatic Thoracic Spinal Cord Laceration Post-Traumatic Thoracic Myelopathy Traumatic Thoracic Spinal Cord Myelopathy
Interventions
DEVICE
No Results Yet
NCT04889872 | RECRUITING | NA
2250 Participants

PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-10-12
Completion: 2029-06-30
Conditions
Aortic Stenosis, Calcific Aortic Valve Stenosis
Interventions
DEVICE
No Results Yet
NCT04868604 | RECRUITING | PHASE1/PHASE2
54 Participants

64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for Identification and Treatment of PSMA-expressing Metastatic Castrate Resistant Prostate Cancer (SECuRE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-08-11
Completion: 2026-09-30
Conditions
Prostatic Neoplasms, Castration-Resistant
Interventions
DRUG
No Results Yet
NCT04867954 | RECRUITING
146 Participants

Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2021-10-28
Completion: 2026-04-30
Conditions
Cirrhosis, Liver Gastroesophageal Varices Fontan Procedure
Interventions
OTHER
No Results Yet
NCT04867317 | RECRUITING | PHASE3
172 Participants

Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-01-13
Completion: 2026-03-01
Conditions
Adult Growth Hormone Deficiency Mild Traumatic Brain Injury
Interventions
DRUG OTHER
No Results Yet
NCT04864275 | COMPLETED
2500 Participants

Personalized Prediction of Persistent Postsurgical Pain

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2021-09-10
Completion: 2025-09-30
Conditions
Pain, Postoperative
No Results Yet
NCT04863885 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
46 Participants

Combination of Ipi/Nivo Plus Sacituzumab Govitecan in Metastatic Cisplatin Ineligible Urothelial Carcinoma Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-04-30
Completion: 2025-09-12
Conditions
Metastatic Urothelial Carcinoma
Interventions
DRUG
No Results Yet
NCT04855032 | COMPLETED | NA
86 Participants

Post-stroke Perturbation Training

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-10-06
Completion: 2025-12-05
Conditions
Stroke
Interventions
BEHAVIORAL
No Results Yet
NCT04852354 | RECRUITING
500 Participants

Tissue Collection for Drug Screening and Bioanalysis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2020-07-22
Completion: 2029-07-22
Conditions
Central Nervous System Tumor
No Results Yet
NCT04851184 | TERMINATED | NA
28 Participants

Dose of Vestibular Rehabilitation for Vestibular Hypofunction

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-03-22
Completion: 2024-09-01
Conditions
Vestibular Disorder
Interventions
DEVICE BEHAVIORAL
NCT04825275 | TERMINATED | EARLY_PHASE1
7 Participants

Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-05-13
Completion: 2024-11-06
Conditions
Glioblastoma Glioblastoma Multiforme Glioblastoma Multiforme of Brain Glioblastoma Multiforme, Adult
Interventions
DRUG
NCT04802356 | ACTIVE_NOT_RECRUITING | PHASE2
50 Participants

Belantamab Mafodotin in Newly Diagnosed Transplant Eligible Multiple Myeloma Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-04-07
Completion: 2025-03-31
Conditions
Multiple Myeloma
Interventions
DRUG PROCEDURE
No Results Yet
NCT04799301 | RECRUITING | PHASE1
60 Participants

Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-02-23
Completion: 2028-01-01
Conditions
Diet Therapy Healthy Volunteers
Interventions
BEHAVIORAL
No Results Yet
NCT04797091 | COMPLETED
500 Participants

Kidney in Coronavirus Disease 2019 Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2020-04-20
Completion: 2025-08-31
Conditions
Corona Virus Infection SARS-CoV 2
Interventions
OTHER
No Results Yet
NCT04742491 | COMPLETED | PHASE2/PHASE3
304 Participants

Pre-Exposure Prophylaxis for Transgender Women in the US and South America

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-03-26
Completion: 2024-08-16
Conditions
HIV Prevention
Interventions
DRUG
NCT04722978 | RECRUITING | PHASE3
228 Participants

Standard Chemotherapy Plus Moxifloxacin as First-line Treatment for Metastatic Triple-negative Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-04-20
Completion: 2026-06-30
Conditions
Triple Negative Breast Cancer
Interventions
DRUG
No Results Yet
NCT04700488 | SUSPENDED | NA
36 Participants

Magnetic Resonance Imaging (MRI) to Predict Outcomes of Pancreatic Ductal Adenocarcinoma (PDAC)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-05-19
Completion: 2026-01-31
Conditions
PDAC - Pancreatic Ductal Adenocarcinoma
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04688658 | TERMINATED | PHASE1/PHASE2
13 Participants

Duvelisib in Combination With Nivolumab in Patients With Advanced Unresectable Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-10-06
Completion: 2024-02-22
Conditions
Unresectable Melanoma
Interventions
DRUG
NCT04680481 | COMPLETED | NA
9 Participants

Non-Invasive Brain Stimulation to Control Large-Scale Brain Networks

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-11-01
Completion: 2025-09-01
Conditions
Working Memory
Interventions
DEVICE
No Results Yet
NCT04666636 | RECRUITING | PHASE2
65 Participants

Mechanisms for Activation of Beige Adipose Tissue in Humans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-12-07
Completion: 2026-06-25
Conditions
PreDiabetes
Interventions
DRUG
No Results Yet
NCT04666077 | COMPLETED | NA
100 Participants

Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-08-27
Completion: 2025-07-15
Conditions
Alzheimer's Disease Mild Cognitive Impairment
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT04647331 | RECRUITING
150 Participants

Betalactam Pharmacokinetics in Endocarditis Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2021-06-01
Completion: 2025-12-31
Conditions
Infective Endocarditis
No Results Yet
NCT04638946 | ACTIVE_NOT_RECRUITING | NA
111 Participants

Exercise for Anxiety

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-06-30
Completion: 2026-01-31
Conditions
Anxiety
Interventions
BEHAVIORAL
No Results Yet
NCT04636801 | TERMINATED | PHASE3
4710 Participants

A 52-week, Placebo-controlled Study to Evaluate the Efficacy and Safety of 2 Doses of CHF6001 DPI (Tanimilast), as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis (PILASTER)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-07-14
Completion: 2025-10-31
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
DRUG
No Results Yet
NCT04630431 | ACTIVE_NOT_RECRUITING | NA
590 Participants

Understanding Challenges, Behavioral Patterns, and Preferences Toward Participation in Clinical Trials in Minority Patient Populations: Development of a Personalized Clinical Trial Educational Platform to Increase Participation in Clinical Trials Among Underserved Cancer Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2019-10-15
Completion: 2026-10-15
Conditions
Hematopoietic and Lymphoid Cell Neoplasm Malignant Solid Neoplasm
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT04629547 | RECRUITING | PHASE2
200 Participants

Sleep Trial to Prevent Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-05-25
Completion: 2026-05-31
Conditions
Sleep Alzheimer Disease
Interventions
DRUG
No Results Yet
NCT04628481 | TERMINATED | PHASE2
141 Participants

A Study of Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-01-12
Completion: 2025-03-31
Conditions
Recent Onset type1 Diabetes
Interventions
DRUG
No Results Yet
NCT04619797 | COMPLETED | PHASE2/PHASE3
542 Participants

A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-12-15
Completion: 2025-11-20
Conditions
Non-small Cell Lung Cancer (NSCLC)
Interventions
DRUG
No Results Yet
NCT04618211 | COMPLETED | PHASE2
74 Participants

Dose-ranging Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-02-03
Completion: 2022-09-23
Conditions
Hereditary Angioedema Hereditary Angioedema Type I Hereditary Angioedema Type II Hereditary Angioedema Types I and II Hereditary Angioedema Attack Hereditary Angioedema With C1 Esterase Inhibitor Deficiency Hereditary Angioedema - Type 1 Hereditary Angioedema - Type 2 C1 Esterase Inhibitor Deficiency C1 Inhibitor Deficiency
Interventions
DRUG
NCT04614168 | ACTIVE_NOT_RECRUITING | NA
24 Participants

Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-07-26
Completion: 2023-09-22
Conditions
Type 1 Diabetes Type 1 Diabetes Mellitus With Hypoglycemia Hypoglycemia Hypoglycemia Unawareness Glucagon Deficiency Insulin Hypoglycemia
Interventions
PROCEDURE DEVICE OTHER
NCT04603495 | ACTIVE_NOT_RECRUITING | PHASE3
430 Participants

Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-04-09
Completion: 2023-08-23
Conditions
Myelofibrosis Primary Myelofibrosis Post-polycythemia Vera Myelofibrosis Post-essential Thrombocythemia Myelofibrosis
Interventions
DRUG
NCT04594798 | ACTIVE_NOT_RECRUITING | PHASE2
39 Participants

A Study of Polatuzumab Vedotin, Rituximab and Dose Attenuated CHP in Older Patients With DLBCL

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-09-20
Completion: 2026-07-31
Conditions
DLBCL Lymphoma, B-Cell
Interventions
DRUG
No Results Yet
NCT04589650 | ACTIVE_NOT_RECRUITING | PHASE2
203 Participants

Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-04-19
Completion: 2024-03-20
Conditions
PIK3CA-related Overgrowth Spectrum (PROS)
Interventions
DRUG
NCT04586699 | ACTIVE_NOT_RECRUITING | NA
50 Participants

Meditation Accelerated Brain Stimulation for Depression

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-07-15
Completion: 2025-04-15
Conditions
Depression
Interventions
DEVICE
No Results Yet
NCT04577014 | RECRUITING | PHASE1/PHASE2
98 Participants

Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-09-29
Completion: 2026-09-29
Conditions
Soft Tissue Sarcoma Sarcoma,Soft Tissue Sarcoma Soft Tissue Sarcoma Adult
Interventions
DRUG
No Results Yet
NCT04556773 | ACTIVE_NOT_RECRUITING | PHASE1
138 Participants

A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2020-12-17
Completion: 2023-08-16
Conditions
Metastatic Breast Cancer
Interventions
DRUG
No Results Yet
NCT04548609 | TERMINATED | NA
1 Participants

Transcranial Direct Current Stimulation (tDCS) in Pediatric Obsessive Compulsive Disorder (OCD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2021-01-25
Completion: 2025-03-05
Conditions
Obsessive-Compulsive Disorder Pediatric Psychiatric Disorder
Interventions
DEVICE
No Results Yet
NCT04543877 | COMPLETED | EARLY_PHASE1
60 Participants

WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2022-09-27
Completion: 2025-06-11
Conditions
Inflammation Vaccine Intestinal Permeability Typhoid Fever
Interventions
DIETARY_SUPPLEMENT BIOLOGICAL
No Results Yet
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