Clinical Trials

Showing trials with last updates posted in 2025.

NCT04677777 | COMPLETED | PHASE1
24 Participants

Safety Study of PP-007 in Subjects With Acute Ischemic Stroke

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-04-24
Completion: 2025-02-20
Conditions
Acute Ischemic Stroke
Interventions
BIOLOGICAL
No Results Yet
NCT04674969 | RECRUITING
5000 Participants

Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2021-03-29
Completion: 2028-01-31
Conditions
Peripheral Vascular Diseases
Interventions
DEVICE
No Results Yet
NCT04667494 | RECRUITING | PHASE4
70 Participants

Ultrasound Therapy In Cardiac Amyloidosis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-08-31
Completion: 2026-04-30
Conditions
Amyloidosis Cardiac
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT04656041 | RECRUITING | PHASE2
40 Participants

Folfox+Irinotecan+Chemort In Esophageal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2021-06-29
Completion: 2024-04-30
Conditions
Gastroesophageal Junction Adenocarcinoma Esophagogastric Cancer
Interventions
DRUG RADIATION
No Results Yet
NCT04636177 | COMPLETED | NA
34 Participants

Pain Rehabilitation Virtual Reality (PRVR): Innovations to Enhance Mobility in the Presence of Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2022-03-10
Completion: 2024-12-07
Conditions
Chronic Pain Musculoskeletal Pain Fibromyalgia Virtual Reality
Interventions
BEHAVIORAL
NCT04612738 | RECRUITING | NA
1500 Participants

Project Talk Trial: Engaging Underserved Communities in End-of-life Conversations

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2022-03-19
Completion: 2026-01-31
Conditions
Advance Care Planning Advance Directives Terminal Illness Chronic Illness Communication
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT04610515 | COMPLETED
6000 Participants

Innovative Support for Patients With SARS-COV2 Infections (COVID-19) Registry (INSPIRE)

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2020-12-15
Completion: 2024-08-31
Conditions
Covid19 ME/CFS SARS COV2 Novel Coronavirus Infection Neurocognitive Disorders Cardiovascular Diseases
No Results Yet
NCT04588545 | RECRUITING | PHASE1/PHASE2
39 Participants

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-12-10
Completion: 2026-08-31
Conditions
HER2-positive Breast Cancer Leptomeningeal Metastasis Leptomeningeal Disease
Interventions
RADIATION DRUG
No Results Yet
NCT04582916 | RECRUITING | PHASE1
64 Participants

PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2021-07-20
Completion: 2029-10-03
Conditions
Depression
Interventions
DRUG
No Results Yet
NCT04579224 | RECRUITING | PHASE3
184 Participants

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2021-06-28
Completion: 2030-08-15
Conditions
Metastatic Bladder Urothelial Carcinoma Metastatic Urothelial Carcinoma Refractory Bladder Urothelial Carcinoma Refractory Urothelial Carcinoma Stage IV Bladder Cancer AJCC v8
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT04569591 | NOT_YET_RECRUITING | NA
22 Participants

Corticotrophin-releasing Hormone (CRH) Stimulation for 18F-FDG-PET Detection of Pituitary Adenoma in Cushing s Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2025-12-31
Conditions
Cushing's Disease Pituitary Adenoma
Interventions
DRUG
No Results Yet
NCT04567771 | RECRUITING | NA
120 Participants

Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-12-04
Completion: 2028-10-15
Conditions
Cervical Carcinoma Endometrial Carcinoma Endometriosis Pelvic Inflammatory Disease
Interventions
OTHER RADIATION
No Results Yet
NCT04561362 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
329 Participants

Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-07-17
Completion: 2026-03-31
Conditions
Urinary Bladder Neoplasm Triple Negative Breast Neoplasms Hormone Receptor Positive, HER2-negative Neoplasms Hormone Receptor Positive, HER2-low Neoplasms Breast Neoplasms Non-Small-Cell Lung Neoplasms Ovarian Neoplasm Advanced Solid Tumor
Interventions
DRUG
No Results Yet
NCT04539808 | ACTIVE_NOT_RECRUITING | PHASE2
60 Participants

NeoOPTIMIZE: Early Switching of mFOLFIRINOX or Gemcitabine/Nab-Paclitaxel Before Surgery for the Treatment of Resectable, Borderline Resectable, or Locally-Advanced Unresectable Pancreatic Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2021-05-27
Completion: 2024-12-08
Conditions
Pancreatic Adenocarcinoma Stage 0 Pancreatic Cancer AJCC v8 Stage I Pancreatic Cancer AJCC v8 Stage III Pancreatic Cancer AJCC v8 Stage IV Pancreatic Cancer AJCC v8
Interventions
DRUG RADIATION PROCEDURE
No Results Yet
NCT04514653 | RECRUITING | PHASE2
140 Participants

RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-08-25
Completion: 2026-08-31
Conditions
Neovascular Age-Related Macular Degeneration (nAMD)
Interventions
BIOLOGICAL GENETIC DRUG
No Results Yet
NCT04501081 | RECRUITING
1100 Participants

Natural History of Autosomal Dominant Hearing Loss

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2021-02-09
Completion: 2029-08-21
Conditions
Hearing Loss
No Results Yet
NCT04488523 | COMPLETED | NA
93 Participants

Family Telehealth Project for Foster Care Youth

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2019-07-01
Completion: 2025-11-01
Conditions
Parent-Child Relations Communication
Interventions
BEHAVIORAL
No Results Yet
NCT04486391 | TERMINATED | PHASE3
3 Participants

Tislelizumab Monotherapy Versus Salvage Chemotherapy for Relapsed/Refractory Classical Hodgkin Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-09-01
Completion: 2025-10-13
Conditions
Classical Hodgkin Lymphoma
Interventions
DRUG
No Results Yet
NCT04473833 | RECRUITING | NA
65000 Participants

Transvaginal Ultrasonography as a Screening Method for Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 1988-12-19
Completion: 2026-12-31
Conditions
Ovarian Cancer
Interventions
PROCEDURE
No Results Yet
NCT04394546 | ACTIVE_NOT_RECRUITING | NA
3000 Participants

CHAMPION-AF Clinical Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-10-15
Completion: 2027-12-31
Conditions
Atrial Fibrillation Stroke Bleeding
Interventions
DEVICE DRUG
No Results Yet
NCT04389632 | RECRUITING | PHASE1
1006 Participants

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-06-08
Completion: 2027-06-16
Conditions
Carcinoma, Non-Small Cell Lung Squamous Cell Carcinoma of Head and Neck HER2 Negative Breast Neoplasms Esophageal Squamous Cell Carcinoma Esophageal Adenocarcinoma Gastroesophageal Junction Adenocarcinoma Ovarian Neoplasms Cutaneous Squamous Cell Cancer Exocrine Pancreatic Adenocarcinoma Urinary Bladder Neoplasms Uterine Cervical Neoplasms Stomach Neoplasms
Interventions
DRUG
No Results Yet
NCT04388332 | RECRUITING | NA
60 Participants

ACDF Using Structural Allograft vs. Tritanium C

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-08-20
Completion: 2026-12-31
Conditions
Degenerative Disc Disease
Interventions
PROCEDURE DEVICE
No Results Yet
NCT04373629 | RECRUITING | NA
146 Participants

Perceptual Abnormalities and Their Malleability in BDD

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-12-01
Completion: 2025-12-01
Conditions
Body Dysmorphic Disorder
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT04370795 | ENROLLING_BY_INVITATION | PHASE1/PHASE2
30 Participants

Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2026-09-09
Conditions
Severe Combined Immune Deficiency (SCID)
Interventions
DRUG RADIATION
No Results Yet
NCT04364854 | COMPLETED | PHASE2
80 Participants

Speech Entrainment for Aphasia Recovery

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-08-21
Completion: 2024-05-08
Conditions
Aphasia Aphasia Non Fluent Stroke
Interventions
BEHAVIORAL OTHER
NCT04350138 | ACTIVE_NOT_RECRUITING | PHASE2
2606 Participants

Safety and Efficacy Study of Meningococcal Group B Vaccine rMenB+OMV NZ (Bexsero) to Prevent Gonococcal Infection

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-12-29
Completion: 2026-02-26
Conditions
Gonococcal Infection
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT04323488 | COMPLETED | NA
90 Participants

Neural Mechanisms of Successful Intervention in Children With Dyslexia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2021-05-01
Completion: 2024-09-01
Conditions
Dyslexia, Developmental
Interventions
BEHAVIORAL
NCT04300556 | RECRUITING | PHASE1/PHASE2
182 Participants
NCT04269213 | SUSPENDED | PHASE2
46 Participants

CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2021-07-29
Completion: 2027-01-29
Conditions
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome Acute Myeloid Leukemia With Myelodysplasia-Related Changes Secondary Acute Myeloid Leukemia Therapy-Related Acute Myeloid Leukemia
Interventions
DRUG
No Results Yet
NCT04265430 | RECRUITING | PHASE4
425 Participants

Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2018-09-17
Completion: 2031-09-01
Conditions
Malignant Oral Cavity Neoplasm Malignant Skull Base Neoplasm Osteoradionecrosis
Interventions
OTHER PROCEDURE
No Results Yet
NCT04246437 | RECRUITING | PHASE1
40 Participants

[18F]F-DOPA Imaging in Patients With Autonomic Failure

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-02-04
Completion: 2026-02-01
Conditions
Autonomic Failure Pure Autonomic Failure Parkinson Disease Multiple System Atrophy Dementia With Lewy Bodies
Interventions
DRUG
No Results Yet
NCT04241835 | RECRUITING | PHASE1
24 Participants

A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-01-15
Completion: 2025-12-19
Conditions
Hepatic Impairment Advanced Malignant Solid Tumor
Interventions
DRUG
No Results Yet
NCT04219956 | RECRUITING | NA
278 Participants

Study to Evaluate the Efficacy of a Polyamine-deficient Diet for Treating Postoperative Pain After Abdominal Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-02-03
Completion: 2027-04-30
Conditions
Digestive System Surgical Procedures
Interventions
OTHER
No Results Yet
NCT04181060 | RECRUITING | PHASE3
300 Participants

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-12-28
Completion: 2026-12-31
Conditions
Advanced Lung Non-Squamous Non-Small Cell Carcinoma Metastatic Lung Non-Squamous Non-Small Cell Carcinoma Recurrent Lung Non-Squamous Non-Small Cell Carcinoma Stage IIIB Lung Cancer AJCC v8 Stage IV Lung Cancer AJCC v8
Interventions
BIOLOGICAL PROCEDURE DRUG
No Results Yet
NCT04168203 | COMPLETED | PHASE4
600 Participants

Extended-Duration Low-Intensity Apixaban to Prevent Recurrence in High-Risk Patients With Provoked Venous Thromboembolism

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2021-03-01
Completion: 2023-11-30
Conditions
Deep Vein Thrombosis Pulmonary Embolism Venous Thromboembolism
Interventions
DRUG
NCT04154111 | ACTIVE_NOT_RECRUITING | NA
180 Participants

Theta Burst Stimulation as a Tool to Decrease Drinking in Treatment-seeking Alcohol Users

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-05-26
Completion: 2026-08-31
Conditions
Alcohol Use Disorder Alcohol Abuse Alcohol Dependence Craving
Interventions
DEVICE
No Results Yet
NCT04106492 | TERMINATED | PHASE1/PHASE2
53 Participants

Phase 1/2a Study of SQ3370 in Patients With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-08-01
Completion: 2023-09-07
Conditions
Cancer
Interventions
DRUG
NCT04077099 | RECRUITING | PHASE1/PHASE2
231 Participants

A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2020-01-07
Completion: 2032-04-22
Conditions
NSCLC
Interventions
DRUG
No Results Yet
NCT04071327 | RECRUITING
3000 Participants

Pulmonary Hypertension Association Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2015-10-31
Completion: 2025-12-31
Conditions
Pulmonary Arterial Hypertension Chronic Thromboembolic Pulmonary Hypertension Pulmonary Hypertension
No Results Yet
NCT04070378 | COMPLETED | PHASE2
16 Participants

Study of Daratumumab in Patients With Mild to Moderate Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2019-11-06
Completion: 2023-06-08
Conditions
Alzheimer Disease
Interventions
DRUG
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