Clinical Trials
Showing trials with last updates posted in 2025.
184
Participants
Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2021-06-28
Completion:
2030-08-15
Conditions
Metastatic Bladder Urothelial Carcinoma
Metastatic Urothelial Carcinoma
Refractory Bladder Urothelial Carcinoma
Refractory Urothelial Carcinoma
Stage IV Bladder Cancer AJCC v8
Interventions
PROCEDURE
DRUG
BIOLOGICAL
No Results Yet
22
Participants
Corticotrophin-releasing Hormone (CRH) Stimulation for 18F-FDG-PET Detection of Pituitary Adenoma in Cushing s Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2025-11-19
Completion:
2025-12-31
Conditions
Cushing's Disease
Pituitary Adenoma
Interventions
DRUG
No Results Yet
120
Participants
Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-12-04
Completion:
2028-10-15
Conditions
Cervical Carcinoma
Endometrial Carcinoma
Endometriosis
Pelvic Inflammatory Disease
Interventions
OTHER
RADIATION
No Results Yet
329
Participants
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-07-17
Completion:
2026-03-31
Conditions
Urinary Bladder Neoplasm
Triple Negative Breast Neoplasms
Hormone Receptor Positive, HER2-negative Neoplasms
Hormone Receptor Positive, HER2-low Neoplasms
Breast Neoplasms
Non-Small-Cell Lung Neoplasms
Ovarian Neoplasm
Advanced Solid Tumor
Interventions
DRUG
No Results Yet
60
Participants
NeoOPTIMIZE: Early Switching of mFOLFIRINOX or Gemcitabine/Nab-Paclitaxel Before Surgery for the Treatment of Resectable, Borderline Resectable, or Locally-Advanced Unresectable Pancreatic Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2021-05-27
Completion:
2024-12-08
Conditions
Pancreatic Adenocarcinoma
Stage 0 Pancreatic Cancer AJCC v8
Stage I Pancreatic Cancer AJCC v8
Stage III Pancreatic Cancer AJCC v8
Stage IV Pancreatic Cancer AJCC v8
Interventions
DRUG
RADIATION
PROCEDURE
No Results Yet
140
Participants
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-08-25
Completion:
2026-08-31
Conditions
Neovascular Age-Related Macular Degeneration (nAMD)
Interventions
BIOLOGICAL
GENETIC
DRUG
No Results Yet
1100
Participants
Natural History of Autosomal Dominant Hearing Loss
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-14
Start Date:
2021-02-09
Completion:
2029-08-21
Conditions
Hearing Loss
No Results Yet
93
Participants
Family Telehealth Project for Foster Care Youth
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2019-07-01
Completion:
2025-11-01
Conditions
Parent-Child Relations
Communication
Interventions
BEHAVIORAL
No Results Yet
3
Participants
Tislelizumab Monotherapy Versus Salvage Chemotherapy for Relapsed/Refractory Classical Hodgkin Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-09-01
Completion:
2025-10-13
Conditions
Classical Hodgkin Lymphoma
Interventions
DRUG
No Results Yet
65000
Participants
Transvaginal Ultrasonography as a Screening Method for Ovarian Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
1988-12-19
Completion:
2026-12-31
Conditions
Ovarian Cancer
Interventions
PROCEDURE
No Results Yet
3000
Participants
CHAMPION-AF Clinical Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-10-15
Completion:
2027-12-31
Conditions
Atrial Fibrillation
Stroke
Bleeding
Interventions
DEVICE
DRUG
No Results Yet
1006
Participants
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-06-08
Completion:
2027-06-16
Conditions
Carcinoma, Non-Small Cell Lung
Squamous Cell Carcinoma of Head and Neck
HER2 Negative Breast Neoplasms
Esophageal Squamous Cell Carcinoma
Esophageal Adenocarcinoma
Gastroesophageal Junction Adenocarcinoma
Ovarian Neoplasms
Cutaneous Squamous Cell Cancer
Exocrine Pancreatic Adenocarcinoma
Urinary Bladder Neoplasms
Uterine Cervical Neoplasms
Stomach Neoplasms
Interventions
DRUG
No Results Yet
60
Participants
ACDF Using Structural Allograft vs. Tritanium C
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-08-20
Completion:
2026-12-31
Conditions
Degenerative Disc Disease
Interventions
PROCEDURE
DEVICE
No Results Yet
146
Participants
Perceptual Abnormalities and Their Malleability in BDD
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-12-01
Completion:
2025-12-01
Conditions
Body Dysmorphic Disorder
Interventions
BEHAVIORAL
OTHER
No Results Yet
30
Participants
Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2025-11-19
Completion:
2026-09-09
Conditions
Severe Combined Immune Deficiency (SCID)
Interventions
DRUG
RADIATION
No Results Yet
80
Participants
Speech Entrainment for Aphasia Recovery
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-08-21
Completion:
2024-05-08
Conditions
Aphasia
Aphasia Non Fluent
Stroke
Interventions
BEHAVIORAL
OTHER
2606
Participants
Safety and Efficacy Study of Meningococcal Group B Vaccine rMenB+OMV NZ (Bexsero) to Prevent Gonococcal Infection
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-12-29
Completion:
2026-02-26
Conditions
Gonococcal Infection
Interventions
BIOLOGICAL
OTHER
No Results Yet
90
Participants
Neural Mechanisms of Successful Intervention in Children With Dyslexia
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2021-05-01
Completion:
2024-09-01
Conditions
Dyslexia, Developmental
Interventions
BEHAVIORAL
182
Participants
A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRฮฑ)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-08-06
Completion:
2030-08-08
Conditions
Solid Tumor
Interventions
DRUG
No Results Yet
46
Participants
CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2021-07-29
Completion:
2027-01-29
Conditions
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Secondary Acute Myeloid Leukemia
Therapy-Related Acute Myeloid Leukemia
Interventions
DRUG
No Results Yet
425
Participants
Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2018-09-17
Completion:
2031-09-01
Conditions
Malignant Oral Cavity Neoplasm
Malignant Skull Base Neoplasm
Osteoradionecrosis
Interventions
OTHER
PROCEDURE
No Results Yet
40
Participants
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-02-04
Completion:
2026-02-01
Conditions
Autonomic Failure
Pure Autonomic Failure
Parkinson Disease
Multiple System Atrophy
Dementia With Lewy Bodies
Interventions
DRUG
No Results Yet
24
Participants
A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-01-15
Completion:
2025-12-19
Conditions
Hepatic Impairment
Advanced Malignant Solid Tumor
Interventions
DRUG
No Results Yet
278
Participants
Study to Evaluate the Efficacy of a Polyamine-deficient Diet for Treating Postoperative Pain After Abdominal Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-02-03
Completion:
2027-04-30
Conditions
Digestive System Surgical Procedures
Interventions
OTHER
No Results Yet
300
Participants
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-12-28
Completion:
2026-12-31
Conditions
Advanced Lung Non-Squamous Non-Small Cell Carcinoma
Metastatic Lung Non-Squamous Non-Small Cell Carcinoma
Recurrent Lung Non-Squamous Non-Small Cell Carcinoma
Stage IIIB Lung Cancer AJCC v8
Stage IV Lung Cancer AJCC v8
Interventions
BIOLOGICAL
PROCEDURE
DRUG
No Results Yet
600
Participants
Extended-Duration Low-Intensity Apixaban to Prevent Recurrence in High-Risk Patients With Provoked Venous Thromboembolism
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2021-03-01
Completion:
2023-11-30
Conditions
Deep Vein Thrombosis
Pulmonary Embolism
Venous Thromboembolism
Interventions
DRUG
180
Participants
Theta Burst Stimulation as a Tool to Decrease Drinking in Treatment-seeking Alcohol Users
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-05-26
Completion:
2026-08-31
Conditions
Alcohol Use Disorder
Alcohol Abuse
Alcohol Dependence
Craving
Interventions
DEVICE
No Results Yet
53
Participants
Phase 1/2a Study of SQ3370 in Patients With Advanced Solid Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-08-01
Completion:
2023-09-07
Conditions
Cancer
Interventions
DRUG
231
Participants
A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-01-07
Completion:
2032-04-22
Conditions
NSCLC
Interventions
DRUG
No Results Yet
3000
Participants
Pulmonary Hypertension Association Registry
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-14
Start Date:
2015-10-31
Completion:
2025-12-31
Conditions
Pulmonary Arterial Hypertension
Chronic Thromboembolic Pulmonary Hypertension
Pulmonary Hypertension
No Results Yet
16
Participants
Study of Daratumumab in Patients With Mild to Moderate Alzheimer's Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2019-11-06
Completion:
2023-06-08
Conditions
Alzheimer Disease
Interventions
DRUG
656
Participants
Trial to Evaluate and Assess the Effect of Comprehensive Pre-ESKD Education on Home Dialysis Use in Veterans
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-03-25
Completion:
2025-09-30
Conditions
Chronic Kidney Disease
End Stage Renal Disease
Hemodialysis
Peritoneal Dialysis
Interventions
OTHER
No Results Yet
7
Participants
Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2019-11-27
Completion:
2023-06-06
Conditions
Non-Hodgkin Lymphoma
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
Chronic Lymphocytic Leukemia
Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Hematopoietic and Lymphoid Cell Neoplasm
Hodgkin Lymphoma
Lymphoblastic Lymphoma
Myelodysplastic Syndrome
Myelofibrosis
Myeloproliferative Neoplasm
Interventions
DRUG
BIOLOGICAL
OTHER
15
Participants
Mesenchymal Stem Cells in the Treatment of Subjects With Advance Chronic Obstructive Pulmonary Disease (COPD)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-01-06
Completion:
2023-11-21
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
BIOLOGICAL
No Results Yet
300
Participants
Pilot Study of BCAA on Sleep
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2019-03-01
Completion:
2025-12-01
Conditions
Sleep Disorder
Traumatic Brain Injury
Interventions
DIETARY_SUPPLEMENT
No Results Yet
300
Participants
Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2019-08-01
Completion:
2025-12-01
Conditions
Traumatic Brain Injury
Interventions
DEVICE
No Results Yet
11
Participants
Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2020-02-10
Completion:
2024-10-17
Conditions
Differentiated Thyroid Gland Carcinoma
Follicular Variant Thyroid Gland Papillary Carcinoma
Poorly Differentiated Thyroid Gland Carcinoma
Refractory Differentiated Thyroid Gland Carcinoma
Refractory Thyroid Gland Carcinoma
Tall Cell Variant Thyroid Gland Papillary Carcinoma
Thyroid Gland Follicular Carcinoma
Thyroid Gland Oncocytic Carcinoma
Thyroid Gland Papillary Carcinoma
Interventions
PROCEDURE
DRUG
BIOLOGICAL
1000
Participants
Connors Protocol for the Management and Use of Stored Human Specimens (Stored Human Specimens)
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-14
Start Date:
2025-11-19
Completion:
2029-12-31
Conditions
Healthy Volunteer Samples
No Results Yet
54
Participants
Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2019-12-14
Completion:
2023-10-30
Conditions
Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm
NF1 Mutation Positive Malignant Peripheral Nerve Sheath Tumor
Unresectable Malignant Solid Neoplasm
Interventions
PROCEDURE
OTHER
DRUG
150
Participants
Comparing Distress Screening + Consultation With Enhanced Usual Care for Caregivers of Cancer Patients
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-14
Start Date:
2019-02-25
Completion:
2025-11-12
Conditions
Cancer Caregivers
Interventions
BEHAVIORAL
No Results Yet
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