Clinical Trials Updated in 2025

NCT07059845 | RECRUITING | PHASE2

320 Participants

A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-10-07

Completion: 2029-01-31

Conditions

Ovarian Cancer

Interventions

DRUG

No Results Yet

NCT07054385 | RECRUITING | NA

60 Participants

I-CARE Rural Pilot: Intervention for Rural-Dwelling Dementia Caregivers

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-07-01

Completion: 2026-05-31

Conditions

Caregiver Burden Alzheimer Disease

Interventions

BEHAVIORAL

No Results Yet

NCT07052903 | RECRUITING | PHASE3

1250 Participants

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-07-02

Completion: 2030-05-28

Conditions

Transthyretin Amyloidosis With Cardiomyopathy

Interventions

DRUG

No Results Yet

NCT07047690 | NOT_YET_RECRUITING | PHASE2

162 Participants

A Study of Nemolizumab for the Treatment of Adults With Systemic Sclerosis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-12-15

Completion: 2026-08-07

Conditions

Systemic Sclerosis

Interventions

DRUG

No Results Yet

NCT07043738 | NOT_YET_RECRUITING | NA

160 Participants

Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2026-01-31

Completion: 2030-10-31

Conditions

Major Depressive Disorder (MDD)

Interventions

PROCEDURE

No Results Yet

NCT07037459 | RECRUITING | PHASE3

5056 Participants

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-06-25

Completion: 2028-06-30

Conditions

Heart Failure With Preserved Ejection Fraction Heart Failure With Mildly Reduced Ejection Fraction Obesity

Interventions

DRUG

No Results Yet

NCT07037433 | RECRUITING | PHASE3

12800 Participants

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-07-25

Completion: 2028-06-30

Conditions

Atherosclerotic Cardiovascular Disease Overweight Obesity

Interventions

DRUG

No Results Yet

NCT07036523 | NOT_YET_RECRUITING | PHASE2

71 Participants

A Study to Find Out Whether BI 765423 Has an Effect on Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF) With or Without Standard Treatment

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-11-15

Completion: 2027-04-28

Conditions

Idiopathic Pulmonary Fibrosis

Interventions

DRUG

No Results Yet

NCT07033494 | RECRUITING | PHASE2

340 Participants

A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-07-16

Completion: 2029-04-30

Conditions

Early Alzheimer's Disease

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT07020663 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated: 2025-11-13

No Results Yet

NCT07015697 | RECRUITING | PHASE1

76 Participants

A Study of Subcutaneous Trastuzumab Deruxtecan in Participants With Metastatic Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-07-17

Completion: 2028-12-31

Conditions

Recurrent or Metastatic Solid Tumors

Interventions

DRUG

No Results Yet

NCT07011732 | RECRUITING | PHASE3

352 Participants

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-07-10

Completion: 2028-11-24

Conditions

Alzheimer Disease

Interventions

DRUG

No Results Yet

NCT07005362 | RECRUITING

36 Participants

Fitbit and AI Chatbot in Sedentary Primary Care Patients With T2D

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2025-09-03

Completion: 2026-04-30

Conditions

Type 2 Diabetes Type 2 Diabetes Mellitus (T2DM) T2DM (Type 2 Diabetes Mellitus) T2D T2DM Remote Patient Monitoring Artificial Intelegence

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT07001748 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

148 Participants

Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-08-19

Completion: 2030-05-30

Conditions

Gastric Adenocarcinoma Gastroesophageal Junction Adenocarcinoma Peritoneal Carcinomatosis

Interventions

DRUG PROCEDURE

No Results Yet

NCT06993610 | RECRUITING | PHASE2

180 Participants

Tibulizumab Skin Healing and Inflammation Evaluation for Lasting Defense

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-05-16

Completion: 2026-09-30

Conditions

Hidradenitis Suppurativa (HS)

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT06993155 | RECRUITING | PHASE2

200 Participants

A Clinical Trial Evaluating the Efficacy and Safety of Leflutrozole on Testicular Function in Men With Hypogonadotropic Hypogonadism (Low Serum Testosterone)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-06-27

Completion: 2026-07-31

Conditions

Hypogonadotropic Hypogonadism

Interventions

DRUG

No Results Yet

NCT06988787 | RECRUITING | NA

136 Participants

Multifaceted Intervention to Restore Resilience and Overcome Risk

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-09-12

Completion: 2028-08-01

Conditions

Military Sexual Trauma Intimate Partner Violence Brain Injury Post Traumatic Stress Disorder

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT06987474 | RECRUITING

400 Participants

Capella Scientia Development Study

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2025-07-30

Completion: 2027-05-31

Conditions

Cataract

Interventions

DEVICE

No Results Yet

NCT06962839 | RECRUITING | PHASE2

300 Participants

A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-06-05

Completion: 2027-09-01

Conditions

Macular Edema

Interventions

DRUG

No Results Yet

NCT06961006 | RECRUITING | PHASE2

160 Participants

A Clinical Study of V940 and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-05-29

Completion: 2028-07-22

Conditions

Malignant Melanoma

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT06957028 | RECRUITING | NA

6000 Participants

CGM for the Early Detection and Management of Hyperglycemia in Pregnancy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-05-27

Completion: 2027-11-27

Conditions

Gestational Diabetes Mellitus in Pregnancy

Interventions

OTHER

No Results Yet

NCT06955169 | NOT_YET_RECRUITING | PHASE2

153 Participants

Comparing the Radiopharmaceutical Drug, [177Lu]Lu-DOTATATE, to Standard of Care Treatment for Patients With Meningioma That Has Come Back After Prior Treatment

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-11-30

Completion: 2029-08-31

Conditions

Intracranial Meningioma

Interventions

DRUG OTHER

No Results Yet

NCT06954285 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated: 2025-11-13

No Results Yet

NCT06945120 | RECRUITING | NA

128 Participants

ACT Lung Health Intervention: Phase Two

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-11-04

Completion: 2026-09-30

Conditions

Smoking Cessation Smoking Behaviors Smoking, Tobacco Smoking, Cigarette Smoking (Tobacco) Addiction

Interventions

BEHAVIORAL

No Results Yet

NCT06935370 | RECRUITING | PHASE3

4200 Participants

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-05-20

Completion: 2029-02-04

Conditions

Heart Failure

Interventions

DRUG

No Results Yet

NCT06928311 | RECRUITING | NA

24 Participants

This Study Explores Whether Adding Natural Elements Like Plants and Sunlight to Indoor Gyms Makes Exercise Feel Easier, More Enjoyable, and Improves Performance. By Comparing Workouts in Nature-inspired and Plain Gym Settings, it Aims to Find Better Ways to Design Fitness Spaces in Cities.

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-04-04

Completion: 2025-11-30

Conditions

Biophilic Environmental Design Traditional Exercise Design

Interventions

OTHER

No Results Yet

NCT06926868 | RECRUITING | PHASE2/PHASE3

500 Participants

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-09-11

Completion: 2028-03-13

Conditions

Breast Neoplasms

Interventions

DRUG

No Results Yet

NCT06923995 | RECRUITING | NA

120 Participants

Expansion and Evaluation of AI-generated Clinical Assessment (AI-COA®) of Depression and Anxiety Severity

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-09-01

Completion: 2026-02-28

Conditions

Depression Disorders Anxiety Disorders

Interventions

OTHER

No Results Yet

NCT06923527 | RECRUITING | PHASE2

50 Participants

Circulating Tumor DNA

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-09-30

Completion: 2027-09-30

Conditions

ER+ Breast Cancer

Interventions

DRUG

No Results Yet

NCT06919991 | COMPLETED | PHASE1

14 Participants

Drug-Drug Interaction Study of Casdatifan in Healthy Adult Participants (ARC-29)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-05-02

Completion: 2025-10-18

Conditions

Healthy Participants

Interventions

DRUG

No Results Yet

NCT06915818 | RECRUITING | NA

65 Participants

Flexagon Plus OTOLoc Colon Anastomosis in Patients Undergoing Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-03-29

Completion: 2025-12-31

Conditions

Colon Anastomosis

Interventions

DEVICE

No Results Yet

NCT06915337 | RECRUITING | NA

75 Participants

Magnet Anastomosis in Patients Undergoing Gastric Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-03-29

Completion: 2025-12-31

Conditions

Gastric Anastomosis (Site)

Interventions

DEVICE

No Results Yet

NCT06914609 | RECRUITING | PHASE3

210 Participants

REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-06-10

Completion: 2027-08-31

Conditions

Angelman Syndrome

Interventions

DRUG

No Results Yet

NCT06910358 | RECRUITING | PHASE3

150 Participants

Study of Bitopertin in Participants With EPP or XLP (APOLLO)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-04-04

Completion: 2026-10-31

Conditions

Erythropoietic Protoporphyria (EPP) X-Linked Protoporphyria (XLP)

Interventions

DRUG

No Results Yet

NCT06907875 | RECRUITING | PHASE1/PHASE2

9 Participants

A First-in-human Study of EPI-321 in Facioscapulohumeral Muscular Dystrophy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-05-08

Completion: 2031-03-31

Conditions

Facioscapulohumeral Muscular Dystrophy

Interventions

BIOLOGICAL

No Results Yet

NCT06907472 | RECRUITING | NA

106 Participants

Diabetes Management for Primary Healthcare Centers.

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-09-15

Completion: 2026-06-15

Conditions

Type 2 Diabetes Mellitus (T2DM)

Interventions

DRUG

No Results Yet

NCT06906471 | NOT_YET_RECRUITING | PHASE1/PHASE2

10 Participants

A Single-Arm, Blinded, Fluorescent PSMA Histopathology Trial of AS1986NS

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-12-31

Completion: 2026-03-31

Conditions

Prostate Cancer Prostate Cancer (Adenocarcinoma) Fluorescence Imaging

Interventions

DRUG

No Results Yet

NCT06901531 | RECRUITING | PHASE3

500 Participants

A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-05-22

Completion: 2029-12-31

Conditions

Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer Metastatic Gastric Adenocarcinoma or Cancer Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT06898957 | RECRUITING | PHASE1

200 Participants

Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-05-16

Completion: 2031-04-23

Conditions

Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT06892522 | RECRUITING | PHASE1/PHASE2

440 Participants

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion Alone or in Combination With Oral, IV, Subcutaneous Daratumumab; Lenalidomide; Dexamethasone; Carfilzomib

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2025-06-30

Completion: 2036-02-29

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet